Vaginal bleeding in pregnancy and adverse clinical outcomes: a systematic review and meta-analysis
Background Vaginal bleeding during pregnancy has been recognised as a significant risk factor for adverse pregnancy outcomes. This study aimed to investigate the association between vaginal bleeding during the first trimester of pregnancy and clinical adverse effects using a systematic review and me...
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| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Journal of Obstetrics and Gynaecology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/01443615.2023.2288224 |
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| author | Arezoo Karimi Kourosh Sayehmiri Mojtaba Vaismoradi Mostafa Dianatinasab Salman Daliri |
| author_facet | Arezoo Karimi Kourosh Sayehmiri Mojtaba Vaismoradi Mostafa Dianatinasab Salman Daliri |
| author_sort | Arezoo Karimi |
| collection | DOAJ |
| description | Background Vaginal bleeding during pregnancy has been recognised as a significant risk factor for adverse pregnancy outcomes. This study aimed to investigate the association between vaginal bleeding during the first trimester of pregnancy and clinical adverse effects using a systematic review and meta-analysis.Methods Databases of Scopus, Web of Science, PubMed (including Medline), Cochrane Library and Science Direct were searched until June of 2023. Data analysis using statistical test fixed- and random-effects models in the meta-analysis, Cochran and meta-regression. The quality of the eligible studies was assessed by using the Newcastle–Ottawa Scale checklist (NOS).Results A total of 46 relevant studies, with a sample size of 1,554,141 were entered into the meta-analysis. Vaginal bleeding during the first trimester of pregnancy increases the risk of preterm birth (OR: 1.8, CI 95%: 1.6–2.0), low birth weight (LBW; OR: 2.0, CI 95%: 1.5–2.6), premature rupture of membranes (PROMs; OR: 2.3, CI 95%: 1.8–3.0), abortion (OR: 4.3, CI 95%: 2.0–9.0), stillbirth (OR: 2.5, CI 95%: 1.2–5.0), placental abruption (OR: 2.2, CI 95%: 1.4–3.3) and placenta previa (OR: 1.9, CI 95%: 1.5–2.4).Conclusions Vaginal bleeding in the first trimester of pregnancy is associated with preterm birth, LBW, PROMs, miscarriage, stillbirth, placental abruption and placenta previa. Therefore, physicians or midwives need to be aware of the possibility of these consequences and manage them when they occur. |
| format | Article |
| id | doaj-art-9e5d6298d7264c2c93ff92c3b40e52c9 |
| institution | Kabale University |
| issn | 0144-3615 1364-6893 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Obstetrics and Gynaecology |
| spelling | doaj-art-9e5d6298d7264c2c93ff92c3b40e52c92025-01-09T12:13:17ZengTaylor & Francis GroupJournal of Obstetrics and Gynaecology0144-36151364-68932024-12-0144110.1080/01443615.2023.2288224Vaginal bleeding in pregnancy and adverse clinical outcomes: a systematic review and meta-analysisArezoo Karimi0Kourosh Sayehmiri1Mojtaba Vaismoradi2Mostafa Dianatinasab3Salman Daliri4Department of Epidemiology, School of Public Health, Shahroud University of Medical Sciences, Shahroud, IranPrevention Center of Social-Mental injuries, Ilam University of Medical Sciences, Ilam, IranFaculty of Nursing and Health Sciences, Nord University, Bodø, NorwayDepartment of Complex Genetics and Epidemiology, School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The NetherlandsClinical Research Development Unit, Imam Hossein Hospital, Shahroud University of Medical Sciences, Shahroud, IranBackground Vaginal bleeding during pregnancy has been recognised as a significant risk factor for adverse pregnancy outcomes. This study aimed to investigate the association between vaginal bleeding during the first trimester of pregnancy and clinical adverse effects using a systematic review and meta-analysis.Methods Databases of Scopus, Web of Science, PubMed (including Medline), Cochrane Library and Science Direct were searched until June of 2023. Data analysis using statistical test fixed- and random-effects models in the meta-analysis, Cochran and meta-regression. The quality of the eligible studies was assessed by using the Newcastle–Ottawa Scale checklist (NOS).Results A total of 46 relevant studies, with a sample size of 1,554,141 were entered into the meta-analysis. Vaginal bleeding during the first trimester of pregnancy increases the risk of preterm birth (OR: 1.8, CI 95%: 1.6–2.0), low birth weight (LBW; OR: 2.0, CI 95%: 1.5–2.6), premature rupture of membranes (PROMs; OR: 2.3, CI 95%: 1.8–3.0), abortion (OR: 4.3, CI 95%: 2.0–9.0), stillbirth (OR: 2.5, CI 95%: 1.2–5.0), placental abruption (OR: 2.2, CI 95%: 1.4–3.3) and placenta previa (OR: 1.9, CI 95%: 1.5–2.4).Conclusions Vaginal bleeding in the first trimester of pregnancy is associated with preterm birth, LBW, PROMs, miscarriage, stillbirth, placental abruption and placenta previa. Therefore, physicians or midwives need to be aware of the possibility of these consequences and manage them when they occur.https://www.tandfonline.com/doi/10.1080/01443615.2023.2288224Uterine haemorrhagevaginal bleedingpregnancy complicationsfirst pregnancy trimestermeta-analysis |
| spellingShingle | Arezoo Karimi Kourosh Sayehmiri Mojtaba Vaismoradi Mostafa Dianatinasab Salman Daliri Vaginal bleeding in pregnancy and adverse clinical outcomes: a systematic review and meta-analysis Journal of Obstetrics and Gynaecology Uterine haemorrhage vaginal bleeding pregnancy complications first pregnancy trimester meta-analysis |
| title | Vaginal bleeding in pregnancy and adverse clinical outcomes: a systematic review and meta-analysis |
| title_full | Vaginal bleeding in pregnancy and adverse clinical outcomes: a systematic review and meta-analysis |
| title_fullStr | Vaginal bleeding in pregnancy and adverse clinical outcomes: a systematic review and meta-analysis |
| title_full_unstemmed | Vaginal bleeding in pregnancy and adverse clinical outcomes: a systematic review and meta-analysis |
| title_short | Vaginal bleeding in pregnancy and adverse clinical outcomes: a systematic review and meta-analysis |
| title_sort | vaginal bleeding in pregnancy and adverse clinical outcomes a systematic review and meta analysis |
| topic | Uterine haemorrhage vaginal bleeding pregnancy complications first pregnancy trimester meta-analysis |
| url | https://www.tandfonline.com/doi/10.1080/01443615.2023.2288224 |
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