High-Grade Late Urinary Toxicity Following Salvage Radiotherapy After Radical Prostatectomy: A Retrospective Cohort Study
Purpose To find out the incidence and predictors for late high-grade genitourinary (GU) toxicity following salvage radiotherapy (SRT), we investigated the consecutive patients who were treated with SRT after radical prostatectomy. Materials and Methods Patients who underwent SRT for biochemical recu...
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Korean Urological Oncology Society
2024-03-01
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| Series: | Journal of Urologic Oncology |
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| Online Access: | http://www.e-juo.org/upload/pdf/juo-244600080004.pdf |
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| author | Seung-Kwon Choi Myong Kim Sang Mi Lee Cheryn Song Jun Hyuk Hong Choung-Soo Kim Hanjong Ahn |
| author_facet | Seung-Kwon Choi Myong Kim Sang Mi Lee Cheryn Song Jun Hyuk Hong Choung-Soo Kim Hanjong Ahn |
| author_sort | Seung-Kwon Choi |
| collection | DOAJ |
| description | Purpose To find out the incidence and predictors for late high-grade genitourinary (GU) toxicity following salvage radiotherapy (SRT), we investigated the consecutive patients who were treated with SRT after radical prostatectomy. Materials and Methods Patients who underwent SRT for biochemical recurrence after radical prostatectomy were reviewed. The incidence of GU toxicity was assessed and risk factors for grade ≥2 and ≥3 GU toxicity were evaluated. The STROBE (STrengthening the Reporting of OBservational studies in Epidemiology) guided the reporting of this study. Results Among the total of 217 patients, 88 patients (40.5%) showed late grade ≥2 GU toxicity. The incidence of late grade ≥3 GU toxicity was 11.5%. The presence of grade ≥2 baseline GU dysfunction (hazard ratio [HR], 6.097; 95% confidence interval [CI], 3.280–11.333; p<0.001) and short interval (<1 year) from surgery to SRT (HR, 1.994; 95% CI, 1.182–3.365; p=0.01) were associated with late grade ≥2 GU toxicity. A short interval from surgery to SRT was an independent predictor of late grade ≥3 GU toxicity (HR, 2.975; 95% CI, 1.135–7.794; p=0.027). Conclusions The incidence of late high-grade GU toxicity was not uncommon after SRT. Thus, care should be taken when we consider SRT in patients with baseline urinary dysfunction and a short interval from surgery to SRT, to determine an optimal treatment strategy with balancing quality of life and oncologic outcome of patients. |
| format | Article |
| id | doaj-art-9e39c3a102a74c4dbf18404cfb5256cc |
| institution | Kabale University |
| issn | 2951-603X 2982-7043 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Korean Urological Oncology Society |
| record_format | Article |
| series | Journal of Urologic Oncology |
| spelling | doaj-art-9e39c3a102a74c4dbf18404cfb5256cc2024-12-03T04:18:38ZengKorean Urological Oncology SocietyJournal of Urologic Oncology2951-603X2982-70432024-03-01221212810.22465/juo.244600080004572High-Grade Late Urinary Toxicity Following Salvage Radiotherapy After Radical Prostatectomy: A Retrospective Cohort StudySeung-Kwon Choi0Myong Kim1Sang Mi Lee2Cheryn Song3Jun Hyuk Hong4Choung-Soo Kim5Hanjong Ahn6 Department of Urology, Seoul Medical Center, Seoul, Korea Department of Urology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea Department of Urology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea Department of Urology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea Department of Urology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea Department of Urology, Ewha Womans University Mokdong Hospital, Seoul, Korea Department of Urology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, KoreaPurpose To find out the incidence and predictors for late high-grade genitourinary (GU) toxicity following salvage radiotherapy (SRT), we investigated the consecutive patients who were treated with SRT after radical prostatectomy. Materials and Methods Patients who underwent SRT for biochemical recurrence after radical prostatectomy were reviewed. The incidence of GU toxicity was assessed and risk factors for grade ≥2 and ≥3 GU toxicity were evaluated. The STROBE (STrengthening the Reporting of OBservational studies in Epidemiology) guided the reporting of this study. Results Among the total of 217 patients, 88 patients (40.5%) showed late grade ≥2 GU toxicity. The incidence of late grade ≥3 GU toxicity was 11.5%. The presence of grade ≥2 baseline GU dysfunction (hazard ratio [HR], 6.097; 95% confidence interval [CI], 3.280–11.333; p<0.001) and short interval (<1 year) from surgery to SRT (HR, 1.994; 95% CI, 1.182–3.365; p=0.01) were associated with late grade ≥2 GU toxicity. A short interval from surgery to SRT was an independent predictor of late grade ≥3 GU toxicity (HR, 2.975; 95% CI, 1.135–7.794; p=0.027). Conclusions The incidence of late high-grade GU toxicity was not uncommon after SRT. Thus, care should be taken when we consider SRT in patients with baseline urinary dysfunction and a short interval from surgery to SRT, to determine an optimal treatment strategy with balancing quality of life and oncologic outcome of patients.http://www.e-juo.org/upload/pdf/juo-244600080004.pdfprostatic neoplasmsradical prostatectomysalvage radiotherapyurinary toxicity |
| spellingShingle | Seung-Kwon Choi Myong Kim Sang Mi Lee Cheryn Song Jun Hyuk Hong Choung-Soo Kim Hanjong Ahn High-Grade Late Urinary Toxicity Following Salvage Radiotherapy After Radical Prostatectomy: A Retrospective Cohort Study Journal of Urologic Oncology prostatic neoplasms radical prostatectomy salvage radiotherapy urinary toxicity |
| title | High-Grade Late Urinary Toxicity Following Salvage Radiotherapy After Radical Prostatectomy: A Retrospective Cohort Study |
| title_full | High-Grade Late Urinary Toxicity Following Salvage Radiotherapy After Radical Prostatectomy: A Retrospective Cohort Study |
| title_fullStr | High-Grade Late Urinary Toxicity Following Salvage Radiotherapy After Radical Prostatectomy: A Retrospective Cohort Study |
| title_full_unstemmed | High-Grade Late Urinary Toxicity Following Salvage Radiotherapy After Radical Prostatectomy: A Retrospective Cohort Study |
| title_short | High-Grade Late Urinary Toxicity Following Salvage Radiotherapy After Radical Prostatectomy: A Retrospective Cohort Study |
| title_sort | high grade late urinary toxicity following salvage radiotherapy after radical prostatectomy a retrospective cohort study |
| topic | prostatic neoplasms radical prostatectomy salvage radiotherapy urinary toxicity |
| url | http://www.e-juo.org/upload/pdf/juo-244600080004.pdf |
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