High-intensity training and irisin response: A possible molecular cross-talk for irisin response
Physical exercise is widely recognized for its positive effect on health through alterations in genetic, molecular, or tissue-level pleiotropic effects. The extent of these advantages hinges on the intensity that elicits optimal threshold adaptation, facilitating interactions and communication withi...
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Elsevier
2025-01-01
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| Series: | Current Research in Physiology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2665944125000252 |
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| author | Ping Li Ligang Tong Xuecui Bi |
| author_facet | Ping Li Ligang Tong Xuecui Bi |
| author_sort | Ping Li |
| collection | DOAJ |
| description | Physical exercise is widely recognized for its positive effect on health through alterations in genetic, molecular, or tissue-level pleiotropic effects. The extent of these advantages hinges on the intensity that elicits optimal threshold adaptation, facilitating interactions and communication within or between the cells. This requires the activation of several proteins, enzymes, and hormones. Irisin, an exercise-triggered hormone, is pivotal in converting white fat into brown fat, enhancing bone health, and optimizing brain functions. The activation of irisin is contingent upon precise exercise protocols that trigger several molecular cross-talks. However, no specific exercise protocols (types/intensity/duration) have been developed. Therefore, establishing specific exercise protocols could reveal irisin-induced benefits on bone and brain health. The present review discussed how high-intensity training (HIT) triggers the irisin response by activating its upstream and downstream molecular signaling pathways and how HIT helps to cross-talk these signaling pathways to improve irisin response. |
| format | Article |
| id | doaj-art-9e1c51a5df7c4eb5a8f0f7b2b51b0594 |
| institution | Kabale University |
| issn | 2665-9441 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Physiology |
| spelling | doaj-art-9e1c51a5df7c4eb5a8f0f7b2b51b05942025-08-25T04:14:47ZengElsevierCurrent Research in Physiology2665-94412025-01-01810016310.1016/j.crphys.2025.100163High-intensity training and irisin response: A possible molecular cross-talk for irisin responsePing Li0Ligang Tong1Xuecui Bi2Faculty of Sports Science, Ningbo University, Jiangbei, Ningbo, Zhejiang, 315211, PR ChinaXianjiang Honors School of Arts and Physical Education, Ningbo Childhood Education College, Qianwan New District, Ningbo, Zhejiang, 315336, PR China; Corresponding author. Xianjiang Honors School of Arts and Physical Education, Ningbo Childhood Education College, 316 Jinci Road, Qianwan New District, Ningbo, Zhejiang, 315336, PR China.Physical Education Institute, Capital University of Physical Education and Sports, Haidian, Beijing, 100091, PR ChinaPhysical exercise is widely recognized for its positive effect on health through alterations in genetic, molecular, or tissue-level pleiotropic effects. The extent of these advantages hinges on the intensity that elicits optimal threshold adaptation, facilitating interactions and communication within or between the cells. This requires the activation of several proteins, enzymes, and hormones. Irisin, an exercise-triggered hormone, is pivotal in converting white fat into brown fat, enhancing bone health, and optimizing brain functions. The activation of irisin is contingent upon precise exercise protocols that trigger several molecular cross-talks. However, no specific exercise protocols (types/intensity/duration) have been developed. Therefore, establishing specific exercise protocols could reveal irisin-induced benefits on bone and brain health. The present review discussed how high-intensity training (HIT) triggers the irisin response by activating its upstream and downstream molecular signaling pathways and how HIT helps to cross-talk these signaling pathways to improve irisin response.http://www.sciencedirect.com/science/article/pii/S2665944125000252Physical exerciseHigh-intensity trainingIrisinBone strengthMolecular signalingCognitive function |
| spellingShingle | Ping Li Ligang Tong Xuecui Bi High-intensity training and irisin response: A possible molecular cross-talk for irisin response Current Research in Physiology Physical exercise High-intensity training Irisin Bone strength Molecular signaling Cognitive function |
| title | High-intensity training and irisin response: A possible molecular cross-talk for irisin response |
| title_full | High-intensity training and irisin response: A possible molecular cross-talk for irisin response |
| title_fullStr | High-intensity training and irisin response: A possible molecular cross-talk for irisin response |
| title_full_unstemmed | High-intensity training and irisin response: A possible molecular cross-talk for irisin response |
| title_short | High-intensity training and irisin response: A possible molecular cross-talk for irisin response |
| title_sort | high intensity training and irisin response a possible molecular cross talk for irisin response |
| topic | Physical exercise High-intensity training Irisin Bone strength Molecular signaling Cognitive function |
| url | http://www.sciencedirect.com/science/article/pii/S2665944125000252 |
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