Next steps for clinical translation of adenosine pathway inhibition in cancer immunotherapy

Next steps for clinical translation of adenosine pathway inhibition in cancer immunotherapy

Increasing evidence supports targeting the adenosine pathway in immuno-oncology with several clinical programs directed at adenosine A2 receptor (A2AR, A2BR), CD73 and CD39 in development. Through a cyclic-AMP-mediated intracellular cascade, adenosine shifts the cytokine and cellular profile of the...

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Bibliographic Details
Main Authors: Riyue Bao, Aung Naing, Lawrence Fong, Jason J. Luke, Robert D. Leone, Ryan C. Augustin
Format: Article
Language:English
Published: BMJ Publishing Group 2022-02-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/10/2/e004089.full
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