Improvement in protein separation by pH excursion modulated ion-exchange chromatography
The transient change in pH during the elution step in ion exchange chromatography is commonly referred to as pH excursion. Acidic pH excursion is usually observed during salt-based elution in cation exchange chromatography. This could have a detrimental effect on protein stability as well as on prot...
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-05-01
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| Series: | Journal of Chromatography Open |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772391725000271 |
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