Diet inflammatory potential modifies the association between tobacco smoke exposure and lung function
Abstract Background The adverse effect of tobacco smoke exposure on lung function varies among individuals. We aim to investigate whether diet inflammatory potential modifies the association between tobacco smoke exposure and lung function. Methods This was a cross-sectional study of 11,382 adults f...
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2025-04-01
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| Online Access: | https://doi.org/10.1186/s12889-025-22454-4 |
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| author | Ying Li Kai Yang |
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| description | Abstract Background The adverse effect of tobacco smoke exposure on lung function varies among individuals. We aim to investigate whether diet inflammatory potential modifies the association between tobacco smoke exposure and lung function. Methods This was a cross-sectional study of 11,382 adults from the 2007–2012 National Health and Nutrition Examination Survey. Tobacco smoke exposure was measured using serum cotinine level, and dichotomized as low or high level according to the race/ethnicity-specific cut-points. Forced expiratory volume in 1 s percent of predicted (FEV1% predicted), forced vital capacity percent of predicted (FVC% predicted) and FEV1/FVC were selected to quantify lung function. Diet inflammatory potential was assessed using dietary inflammatory index (DII), and categorized into quartiles. The modification effect of DII on the relationship between tobacco smoke exposure and lung function were evaluated by multivariate linear regression model with interaction term and stratified analysis. Results DII interacted with serum cotinine level in association with FEV1% predicted, FVC% predicted and FEV1/FVC (P for interaction < 0.05). In individuals with higher DII, serum cotinine level had stronger inverse associations with FEV1% predicted, FVC% predicted and FEV1/FVC. More specifically, 23 of 28 DII components showed modification effects on the relationship between serum cotinine level and lung function. Conclusions Diet inflammatory potential modifies the effect of tobacco smoke exposure on lung function, and tobacco smoke exposure had a stronger adverse impact on lung function among individuals with high diet inflammatory potential, which should attract more attention. |
| format | Article |
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| institution | DOAJ |
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| spelling | doaj-art-9dfb45d0ffb7497aabeefacf957e65862025-08-20T03:04:53ZengBMCBMC Public Health1471-24582025-04-012511610.1186/s12889-025-22454-4Diet inflammatory potential modifies the association between tobacco smoke exposure and lung functionYing Li0Kai Yang1Department of Science and Education, the Third People’s Hospital of Longgang, Clinical Institute of Shantou University Medical College (the Third People’s Hospital of Longgang District Shenzhen)Shenzhen Institute of Respiratory Diseases, Shenzhen People’s Hospital (the Second Clinical Medical College Jinan University, the First Affiliated Hospital, Southern University of Science and Technology)Abstract Background The adverse effect of tobacco smoke exposure on lung function varies among individuals. We aim to investigate whether diet inflammatory potential modifies the association between tobacco smoke exposure and lung function. Methods This was a cross-sectional study of 11,382 adults from the 2007–2012 National Health and Nutrition Examination Survey. Tobacco smoke exposure was measured using serum cotinine level, and dichotomized as low or high level according to the race/ethnicity-specific cut-points. Forced expiratory volume in 1 s percent of predicted (FEV1% predicted), forced vital capacity percent of predicted (FVC% predicted) and FEV1/FVC were selected to quantify lung function. Diet inflammatory potential was assessed using dietary inflammatory index (DII), and categorized into quartiles. The modification effect of DII on the relationship between tobacco smoke exposure and lung function were evaluated by multivariate linear regression model with interaction term and stratified analysis. Results DII interacted with serum cotinine level in association with FEV1% predicted, FVC% predicted and FEV1/FVC (P for interaction < 0.05). In individuals with higher DII, serum cotinine level had stronger inverse associations with FEV1% predicted, FVC% predicted and FEV1/FVC. More specifically, 23 of 28 DII components showed modification effects on the relationship between serum cotinine level and lung function. Conclusions Diet inflammatory potential modifies the effect of tobacco smoke exposure on lung function, and tobacco smoke exposure had a stronger adverse impact on lung function among individuals with high diet inflammatory potential, which should attract more attention.https://doi.org/10.1186/s12889-025-22454-4Tobacco smokeLung functionDietary inflammatory indexInteraction |
| spellingShingle | Ying Li Kai Yang Diet inflammatory potential modifies the association between tobacco smoke exposure and lung function BMC Public Health Tobacco smoke Lung function Dietary inflammatory index Interaction |
| title | Diet inflammatory potential modifies the association between tobacco smoke exposure and lung function |
| title_full | Diet inflammatory potential modifies the association between tobacco smoke exposure and lung function |
| title_fullStr | Diet inflammatory potential modifies the association between tobacco smoke exposure and lung function |
| title_full_unstemmed | Diet inflammatory potential modifies the association between tobacco smoke exposure and lung function |
| title_short | Diet inflammatory potential modifies the association between tobacco smoke exposure and lung function |
| title_sort | diet inflammatory potential modifies the association between tobacco smoke exposure and lung function |
| topic | Tobacco smoke Lung function Dietary inflammatory index Interaction |
| url | https://doi.org/10.1186/s12889-025-22454-4 |
| work_keys_str_mv | AT yingli dietinflammatorypotentialmodifiestheassociationbetweentobaccosmokeexposureandlungfunction AT kaiyang dietinflammatorypotentialmodifiestheassociationbetweentobaccosmokeexposureandlungfunction |