Bioconversion of Alpha-Cembratriene-4,6-diol into High-Value Compound Farnesal Through Employment of a Novel <i>Stenotrophomonas maltophilia</i> H3-1 Strain

Bioconversion of Alpha-Cembratriene-4,6-diol into High-Value Compound Farnesal Through Employment of a Novel <i>Stenotrophomonas maltophilia</i> H3-1 Strain

Alpha-cembratriene-4,6-diol (α-CBT-diol) is a complex diterpenoid primarily found in <i>Solanaceae</i> (i.e., tobacco leaves), <i>Pinaceae</i>, and marine corals. Due to its intricate chemical structure, it serves as a precursor for several aroma compounds, including farnesal...

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Bibliographic Details
Main Authors: Shen Huang, Jiaming Cheng, Huibo Hu, Aamir Rasool, Robina Manzoor, Duobin Mao
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Molecules
Subjects:
<i>Stenotrophomonas</i>
bioconversion
?-cembratriene-4,6-diol
farnesal
?-CBT-diol
Online Access:https://www.mdpi.com/1420-3049/30/5/1090
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Summary:Alpha-cembratriene-4,6-diol (α-CBT-diol) is a complex diterpenoid primarily found in <i>Solanaceae</i> (i.e., tobacco leaves), <i>Pinaceae</i>, and marine corals. Due to its intricate chemical structure, it serves as a precursor for several aroma compounds, including farnesal. Farnesal and its derivatives have applications across various fields, such as the fragrance and flavor industry, pharmaceuticals, agriculture, and cosmetics. In this study, <i>Stenotrophomonas maltophilia</i> H3-1, a strain capable of efficiently biodegrading α-CBT-diol into farnesal, was isolated from soil and identified through 16S rDNA sequence analysis. <i>S. maltophilia</i> H3-1 biodegraded 93.3% of α-CBT-diol (300 mg/L) within 36 h when grown under optimized culture conditions, including a temperature of 40 °C, pH of 8, 2 g/L maltose, and 2 g/L ammonium sulfate. Theoretically, this strain can produce 201 mg/L of farnesal during the biotransformation of α-CBT-diol. The putative α-CBT-diol bioconversion pathway expressed in <i>S. maltophilia</i> H3-1 is also proposed. This is the first study to report the bioconversion of α-CBT-diol into the high-value compound farnesal using a novel <i>S. maltophilia</i> H3-1 strain. It highlights that other compounds found in tobacco can also be bioconverted into valuable products.
ISSN:1420-3049

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