Extensive folding variability between homologous chromosomes in mammalian cells

Extensive folding variability between homologous chromosomes in mammalian cells

Abstract Genetic variation and 3D chromatin structure have major roles in gene regulation. Due to challenges in mapping chromatin conformation with haplotype-specific resolution, the effects of genetic sequence variation on 3D genome structure and gene expression imbalance remain understudied. Here,...

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Main Authors: Ibai Irastorza-Azcarate, Alexander Kukalev, Rieke Kempfer, Christoph J Thieme, Guido Mastrobuoni, Julia Markowski, Gesa Loof, Thomas M Sparks, Emily Brookes, Kedar Nath Natarajan, Stephan Sauer, Amanda G Fisher, Mario Nicodemi, Bing Ren, Roland F Schwarz, Stefan Kempa, Ana Pombo
Format: Article
Language:English
Published: Springer Nature 2025-05-01
Series:Molecular Systems Biology
Subjects:
Genome Structure
Gene Regulation
Allele-specific Expression
Polycomb
Histone Locus
Online Access:https://doi.org/10.1038/s44320-025-00107-3
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https://doi.org/10.1038/s44320-025-00107-3

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