A novel process for transcellular hemoglobin transport from macrophages to cancer cells

A novel process for transcellular hemoglobin transport from macrophages to cancer cells

Abstract Hemoglobin (Hb) performs its physiological function within the erythrocyte. Extracellular Hb has prooxidative and proinflammatory properties and is therefore sequestered by haptoglobin and bound by the CD163 receptor on macrophages. In the present study, we demonstrate a novel process of Hb...

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Bibliographic Details
Main Authors: Agata Braniewska, Marcin Skorzynski, Zuzanna Sas, Magdalena Dlugolecka, Ilona Marszalek, Daria Kurpiel, Marcel Bühler, Damian Strzemecki, Aneta Magiera, Maciej Bialasek, Jaroslaw Walczak, Lukasz Cheda, Michal Komorowski, Tobias Weiss, Małgorzata Czystowska-Kuzmicz, Karina Kwapiszewska, Alberto Boffi, Magdalena Krol, Tomasz P. Rygiel
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Cell Communication and Signaling
Subjects:
Hemoglobin
Macrophages
CD163
Extracellular vesicles
Monomethyl auristatin E
Online Access:https://doi.org/10.1186/s12964-024-01929-8
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