Fabrication and characterization of rGO-SnO2 nanocomposite for electrochemical sensor of ciprofloxacin
The uncontrolled use of ciprofloxacin (CIP) has led to increased resistance in patients and potential health issues such as kidney disorders, digestive disorder, and liver complications. This study addresses these concerns by introducing an innovative electrochemical sensor utilizing a screen-printe...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-01-01
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| Series: | Sensors International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666351123000505 |
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| author | Prastika Krisma Jiwanti Dewi Kartika Azizah Sukardi Anis Puspita Sari Mai Tomisaki Siti Wafiroh Sri Hartati Arramel Yew Hoong Wong Pei Meng Woi Joon Ching Juan |
| author_facet | Prastika Krisma Jiwanti Dewi Kartika Azizah Sukardi Anis Puspita Sari Mai Tomisaki Siti Wafiroh Sri Hartati Arramel Yew Hoong Wong Pei Meng Woi Joon Ching Juan |
| author_sort | Prastika Krisma Jiwanti |
| collection | DOAJ |
| description | The uncontrolled use of ciprofloxacin (CIP) has led to increased resistance in patients and potential health issues such as kidney disorders, digestive disorder, and liver complications. This study addresses these concerns by introducing an innovative electrochemical sensor utilizing a screen-printed electrode (SPE) enhanced with a novel rGO-SnO2 nanocomposite for the precise monitoring of CIP concentration. Through square wave voltammetry (SWV), this sensor demonstrates unparalleled sensitivity and accuracy in determining CIP levels. These analyses validated the superior performance of the SPE/rGO-SnO2 electrode, revealing CIP potential range of 0.85–1.50 V with irreversible oxidation reaction and an exceptional signal-to-background (S/B) ratio of 1.91, surpassing the 1.21 ratio achieved by the SPE/rGO electrode. The SPE/rGO-SnO2 electrode also exhibited the highest active surface area (0.0252 cm2), facilitating faster transfer electron. Crucially, the SPE/rGO-SnO2 electrode exhibited an impressively low limit of detection (LOD) at 2.03 μM within a concentration range of 30–100 μM for CIP, setting a new benchmark for sensitivity (9.348 μA/μM) in CIP detection. The %RSD value was less than 5 % indicating that this modified electrodes exhibit good precision and stability. The real-world applicability of this developed methods was exemplified through its successful implementation in the analysis of river water and milk, achieving remarkable recovery rates of 101.2 % and 97.7 %, respectively. Consequently, the SPE modified with rGO-SnO2 nanocomposite emerges as a highly promising and effective tool for precise and sensitive CIP measurement, offering unparalleled performance metrics and opening avenues for enhanced environmental and health monitoring. |
| format | Article |
| id | doaj-art-9dd0509be4504a1abd9e1675519efc98 |
| institution | Kabale University |
| issn | 2666-3511 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Sensors International |
| spelling | doaj-art-9dd0509be4504a1abd9e1675519efc982025-01-04T04:57:07ZengKeAi Communications Co., Ltd.Sensors International2666-35112024-01-015100276Fabrication and characterization of rGO-SnO2 nanocomposite for electrochemical sensor of ciprofloxacinPrastika Krisma Jiwanti0Dewi Kartika Azizah Sukardi1Anis Puspita Sari2Mai Tomisaki3Siti Wafiroh4Sri Hartati5 Arramel6Yew Hoong Wong7Pei Meng Woi8Joon Ching Juan9Nanotechnology Engineering, Faculty of Advanced Technology and Multidiscipline, University of Airlangga, Surabaya, 60115, Indonesia; Corresponding author.Department of Chemistry, Faculty of Science and Technology, University of Airlangga, Surabaya, 60115, IndonesiaDepartment of Chemistry, Faculty of Science and Technology, University of Airlangga, Surabaya, 60115, IndonesiaInternational Institute for Carbon-Neutral Energy Research (WPI-I2CNER), Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, JapanDepartment of Chemistry, Faculty of Science and Technology, University of Airlangga, Surabaya, 60115, IndonesiaNano Center Indonesia, Jalan Raya PUSPIPTEK, South Tangerang, Banten, 15314, IndonesiaNano Center Indonesia, Jalan Raya PUSPIPTEK, South Tangerang, Banten, 15314, IndonesiaNanotechnology Engineering, Faculty of Advanced Technology and Multidiscipline, University of Airlangga, Surabaya, 60115, Indonesia; Department of Mechanical Engineering, Faculty of Engineering, Universiti Malaya, Kuala Lumpur, 50603, MalaysiaChemistry Department, Faculty of Science, Universiti Malaya, Kuala Lumpur, 50603, MalaysiaNanotechnology & Catalyst Research Centre (NANOCAT), Institute for Advanced Studies, University Malaya, Kuala Lumpur, 50603, MalaysiaThe uncontrolled use of ciprofloxacin (CIP) has led to increased resistance in patients and potential health issues such as kidney disorders, digestive disorder, and liver complications. This study addresses these concerns by introducing an innovative electrochemical sensor utilizing a screen-printed electrode (SPE) enhanced with a novel rGO-SnO2 nanocomposite for the precise monitoring of CIP concentration. Through square wave voltammetry (SWV), this sensor demonstrates unparalleled sensitivity and accuracy in determining CIP levels. These analyses validated the superior performance of the SPE/rGO-SnO2 electrode, revealing CIP potential range of 0.85–1.50 V with irreversible oxidation reaction and an exceptional signal-to-background (S/B) ratio of 1.91, surpassing the 1.21 ratio achieved by the SPE/rGO electrode. The SPE/rGO-SnO2 electrode also exhibited the highest active surface area (0.0252 cm2), facilitating faster transfer electron. Crucially, the SPE/rGO-SnO2 electrode exhibited an impressively low limit of detection (LOD) at 2.03 μM within a concentration range of 30–100 μM for CIP, setting a new benchmark for sensitivity (9.348 μA/μM) in CIP detection. The %RSD value was less than 5 % indicating that this modified electrodes exhibit good precision and stability. The real-world applicability of this developed methods was exemplified through its successful implementation in the analysis of river water and milk, achieving remarkable recovery rates of 101.2 % and 97.7 %, respectively. Consequently, the SPE modified with rGO-SnO2 nanocomposite emerges as a highly promising and effective tool for precise and sensitive CIP measurement, offering unparalleled performance metrics and opening avenues for enhanced environmental and health monitoring.http://www.sciencedirect.com/science/article/pii/S2666351123000505Human & healthElectrochemical sensorCiprofloxacinrGO-SnO2Screen printed electrode |
| spellingShingle | Prastika Krisma Jiwanti Dewi Kartika Azizah Sukardi Anis Puspita Sari Mai Tomisaki Siti Wafiroh Sri Hartati Arramel Yew Hoong Wong Pei Meng Woi Joon Ching Juan Fabrication and characterization of rGO-SnO2 nanocomposite for electrochemical sensor of ciprofloxacin Sensors International Human & health Electrochemical sensor Ciprofloxacin rGO-SnO2 Screen printed electrode |
| title | Fabrication and characterization of rGO-SnO2 nanocomposite for electrochemical sensor of ciprofloxacin |
| title_full | Fabrication and characterization of rGO-SnO2 nanocomposite for electrochemical sensor of ciprofloxacin |
| title_fullStr | Fabrication and characterization of rGO-SnO2 nanocomposite for electrochemical sensor of ciprofloxacin |
| title_full_unstemmed | Fabrication and characterization of rGO-SnO2 nanocomposite for electrochemical sensor of ciprofloxacin |
| title_short | Fabrication and characterization of rGO-SnO2 nanocomposite for electrochemical sensor of ciprofloxacin |
| title_sort | fabrication and characterization of rgo sno2 nanocomposite for electrochemical sensor of ciprofloxacin |
| topic | Human & health Electrochemical sensor Ciprofloxacin rGO-SnO2 Screen printed electrode |
| url | http://www.sciencedirect.com/science/article/pii/S2666351123000505 |
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