A homeostatic model of IκB metabolism to control constitutive NF‐κB activity
Abstract Cellular signal transduction pathways are usually studied following administration of an external stimulus. However, disease‐associated aberrant activity of the pathway is often due to misregulation of the equilibrium state. The transcription factor NF‐κB is typically described as being hel...
Saved in:
| Main Authors: | Ellen L O'Dea, Derren Barken, Raechel Q Peralta, Kim T Tran, Shannon L Werner, Jeffrey D Kearns, Andre Levchenko, Alexander Hoffmann |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer Nature
2007-05-01
|
| Series: | Molecular Systems Biology |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/msb4100148 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Understanding NF‐κB signaling via mathematical modeling
by: Raymond Cheong, et al.
Published: (2008-05-01) -
Gut modulation to regulate NF-κB in colorectal and gastric cancer therapy and inflammation
by: Rowan Kearns
Published: (2025-07-01) -
Alfalfa Flavonoids Mitigate Salmonella‐Induced Colitis via the Keap1‐Nrf2 and TLR4/NF‐κB/COX‐2 Pathways
by: Xiaoli Qin, et al.
Published: (2025-07-01) -
The Mechanism of Calcium Handling Proteins and NF-κB in Calcium Dyshomeostasis of Cardiomyocytes Caused by Acute MDMA Exposure
by: WANG Rong-shuai, et al.
Published: (2025-04-01) -
Lang-chuang-ding restores bone homeostasis in systemic lupus erythematosus associated osteoporosis by targeting NF-κB signaling: a network pharmacology and experimental study
by: Huan Luo, et al.
Published: (2025-07-01)