Healthcare costs and resource utilization of patients with chronic post-traumatic stress disorder: a retrospective US claims analysis of commercially insured patients
Aim: Exploring the healthcare costs and resource use among privately insured US patients with posttraumatic stress disorder (PTSD). Methods: This study used Merative MarketScan data. The index date was defined as the first PTSD claim. Study period included a 1-year pre-index and 2-year post-index...
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Becaris Publishing Limited
2024-11-01
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| Series: | Journal of Comparative Effectiveness Research |
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| author | Filip Stanicic Vladimir Zah Dimitrije Grbic Debra de Angelo Wendy Bibeau |
| author_facet | Filip Stanicic Vladimir Zah Dimitrije Grbic Debra de Angelo Wendy Bibeau |
| author_sort | Filip Stanicic |
| collection | DOAJ |
| description | Aim: Exploring the healthcare costs and resource use among privately insured US patients with posttraumatic
stress disorder (PTSD). Methods: This study used Merative MarketScan data. The index date was
defined as the first PTSD claim. Study period included a 1-year pre-index and 2-year post-index follow-up.
Cases with only acute PTSD, cancer, or insurance gap during the study period were excluded. The PTSD
with (PwC) and PTSD without comorbidities (PwoC) cohorts were defined by the presence/absence of
comorbid mental health conditions (schizophrenia, bipolar and major depressive disorder). Baseline PTSD
(BP) cohort included PwoC cases with only index PTSD event and without FDA-approved PTSDmedications
or psychotherapy. Sub-analysis is conducted among patients with PTSD and substance/alcohol use disorder.
Study cohorts were matched in a 1:1:1 ratio. Results: The matched sample included 5076 patients (1681
PwC, 1681 PwoC, 1714 BP). PwC patients had higher 2-year PTSD-related costs than PwoC and BP patients
($3762 vs $1750 and $841; all p < 0.001). The same trend was noted among all-cause and anxiety-related
costs. PwC patients had higher 2-year PTSD-related inpatient and emergency department (ED) rates than
PwoC (10.2% vs 1.7% and 6.8% vs 2.6%, all p < 0.001) and inpatient and outpatient rates than BP (10.2%
vs 2.1% and 98.0% vs 93.1%; all p ≤ 0.004). The sub-analysis had 3776 patients (3154 PwC, 537 PwoC, 85
BP). PwC had higher 2-year PTSD-related costs than PwoC and BP ($7668 vs $2919 and $1,483; all p < 0.001).
The same trend was noted in all-cause and anxiety-related costs. PwC also had higher 2-year PTSD-related
inpatient and ED rates than PwoC (25.6% vs 10.4% and 12.7% vs 5.2%; all p < 0.001) and inpatient and
outpatient rates than BP (25.6% vs 8.2% and 95.5% vs 84.7%; all p < 0.001). Conclusion: PTSD is associated
with high healthcare costs and resource use. The highest economic burden was observed in patients with
PTSD and mental health comorbidities. |
| format | Article |
| id | doaj-art-9dc54ee0cc5d41029d35d4ed4c83e382 |
| institution | Kabale University |
| issn | 2042-6313 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Becaris Publishing Limited |
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| series | Journal of Comparative Effectiveness Research |
| spelling | doaj-art-9dc54ee0cc5d41029d35d4ed4c83e3822024-11-29T10:55:41ZengBecaris Publishing LimitedJournal of Comparative Effectiveness Research2042-63132024-11-01131210.57264/cer-2024-0058Healthcare costs and resource utilization of patients with chronic post-traumatic stress disorder: a retrospective US claims analysis of commercially insured patientsFilip Stanicic0https://orcid.org/0000-0003-2293-8940Vladimir Zah1https://orcid.org/0000-0003-1368-4491Dimitrije Grbic2https://orcid.org/0009-0005-4962-4396Debra de Angelo3Wendy Bibeau4Health Economics & Outcomes Research Department, ZRx Outcomes Research Inc., Mississauga, ON L5A 2X7, CanadaHealth Economics & Outcomes Research Department, ZRx Outcomes Research Inc., Mississauga, ON L5A 2X7, CanadaHealth Economics & Outcomes Research Department, ZRx Outcomes Research Inc., Mississauga, ON L5A 2X7, CanadaLykos Therapeutics, 3141 Stevens Creek Blvd #40547, San Jose, CA 95117, USALykos Therapeutics, 3141 Stevens Creek Blvd #40547, San Jose, CA 95117, USAAim: Exploring the healthcare costs and resource use among privately insured US patients with posttraumatic stress disorder (PTSD). Methods: This study used Merative MarketScan data. The index date was defined as the first PTSD claim. Study period included a 1-year pre-index and 2-year post-index follow-up. Cases with only acute PTSD, cancer, or insurance gap during the study period were excluded. The PTSD with (PwC) and PTSD without comorbidities (PwoC) cohorts were defined by the presence/absence of comorbid mental health conditions (schizophrenia, bipolar and major depressive disorder). Baseline PTSD (BP) cohort included PwoC cases with only index PTSD event and without FDA-approved PTSDmedications or psychotherapy. Sub-analysis is conducted among patients with PTSD and substance/alcohol use disorder. Study cohorts were matched in a 1:1:1 ratio. Results: The matched sample included 5076 patients (1681 PwC, 1681 PwoC, 1714 BP). PwC patients had higher 2-year PTSD-related costs than PwoC and BP patients ($3762 vs $1750 and $841; all p < 0.001). The same trend was noted among all-cause and anxiety-related costs. PwC patients had higher 2-year PTSD-related inpatient and emergency department (ED) rates than PwoC (10.2% vs 1.7% and 6.8% vs 2.6%, all p < 0.001) and inpatient and outpatient rates than BP (10.2% vs 2.1% and 98.0% vs 93.1%; all p ≤ 0.004). The sub-analysis had 3776 patients (3154 PwC, 537 PwoC, 85 BP). PwC had higher 2-year PTSD-related costs than PwoC and BP ($7668 vs $2919 and $1,483; all p < 0.001). The same trend was noted in all-cause and anxiety-related costs. PwC also had higher 2-year PTSD-related inpatient and ED rates than PwoC (25.6% vs 10.4% and 12.7% vs 5.2%; all p < 0.001) and inpatient and outpatient rates than BP (25.6% vs 8.2% and 95.5% vs 84.7%; all p < 0.001). Conclusion: PTSD is associated with high healthcare costs and resource use. The highest economic burden was observed in patients with PTSD and mental health comorbidities.alcohol use disorderdisease severityeconomic burdenhealthcare costshospitalizationmental healthpost-traumatic stress disorderreal-world evidenceresource usesubstance use disorder |
| spellingShingle | Filip Stanicic Vladimir Zah Dimitrije Grbic Debra de Angelo Wendy Bibeau Healthcare costs and resource utilization of patients with chronic post-traumatic stress disorder: a retrospective US claims analysis of commercially insured patients Journal of Comparative Effectiveness Research alcohol use disorder disease severity economic burden healthcare costs hospitalization mental health post-traumatic stress disorder real-world evidence resource use substance use disorder |
| title | Healthcare costs and resource utilization of patients with chronic post-traumatic stress disorder: a retrospective US claims analysis of commercially insured patients |
| title_full | Healthcare costs and resource utilization of patients with chronic post-traumatic stress disorder: a retrospective US claims analysis of commercially insured patients |
| title_fullStr | Healthcare costs and resource utilization of patients with chronic post-traumatic stress disorder: a retrospective US claims analysis of commercially insured patients |
| title_full_unstemmed | Healthcare costs and resource utilization of patients with chronic post-traumatic stress disorder: a retrospective US claims analysis of commercially insured patients |
| title_short | Healthcare costs and resource utilization of patients with chronic post-traumatic stress disorder: a retrospective US claims analysis of commercially insured patients |
| title_sort | healthcare costs and resource utilization of patients with chronic post traumatic stress disorder a retrospective us claims analysis of commercially insured patients |
| topic | alcohol use disorder disease severity economic burden healthcare costs hospitalization mental health post-traumatic stress disorder real-world evidence resource use substance use disorder |
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