Global respiratory tumor mortality correlation study with economic level, 2000–2019
ObjectiveThe study aimed to investigate the relationship between global tracheobronchial lung cancer mortality rates and economic levels and assess the associated regional economic burden. Understanding these associations is crucial for global health resource allocation, informing cancer prevention...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1647634/full |
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| author | Mingjie Wang Mingjie Wang Zhiyuan Chen |
| author_facet | Mingjie Wang Mingjie Wang Zhiyuan Chen |
| author_sort | Mingjie Wang |
| collection | DOAJ |
| description | ObjectiveThe study aimed to investigate the relationship between global tracheobronchial lung cancer mortality rates and economic levels and assess the associated regional economic burden. Understanding these associations is crucial for global health resource allocation, informing cancer prevention and control strategies, and providing data to support the development of lung cancer and economic policies worldwide.MethodsWe analyzed respiratory cancer mortality data (International Classification of Diseases (ICD)-10 codes C33-C34) obtained from the World Health Organization (WHO) Mortality Database (2000–2019). Age-standardized mortality rates (ASMRs) were calculated to describe the spatiotemporal distribution characteristics. Non-parametric comparisons (Wilcoxon rank-sum test) were performed to assess gender differences in mortality. Spearman’s partial rank correlation analysis was performed to evaluate the association between national income levels (World Bank classification) and disease mortality.ResultsThe core cohort included 50 countries with sufficient data. The global mean ASMR for respiratory cancers showed a decreasing trend from 2000 to 2019. Countries included in the Global Respiratory Tumor Mortality Registry System (GRTMRS) were predominantly high-income (68%) and European (52%). A significant positive correlation was observed between income levels and respiratory cancer mortality (Spearman’s ρ = 0.422, p < 0.001). ASMRs were consistently and significantly higher among male individuals than female individuals (Wilcoxon rank-sum test, p < 0.001).ConclusionBetween 2000 and 2019, global tracheobronchial lung cancer mortality appeared to be positively correlated with national economic level, particularly in high- and middle-income countries. Age-standardized mortality rates were significantly higher in male individuals than in female individuals. Paradoxically, these findings suggest that increasing economic development may be associated with elevated respiratory cancer mortality rates, emphasizing the critical need for balanced prevention strategies tailored to both high- and low-income settings. |
| format | Article |
| id | doaj-art-9d4d7953f76e4053bb0f95bcd7529b99 |
| institution | Kabale University |
| issn | 2296-2565 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj-art-9d4d7953f76e4053bb0f95bcd7529b992025-08-20T04:03:27ZengFrontiers Media S.A.Frontiers in Public Health2296-25652025-08-011310.3389/fpubh.2025.16476341647634Global respiratory tumor mortality correlation study with economic level, 2000–2019Mingjie Wang0Mingjie Wang1Zhiyuan Chen2Department of Emergency Medicine, Qilu Hospital of Shandong University, Jinan, ChinaShandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, NMPA Key Laboratory for Clinical Research and Evaluation of Innovative Drug, Medical and Pharmaceutical Basic Research Innovation Center of Emergency and Critical Care Medicine, China’s Ministry of Education, Shandong Provincial Engineering Laboratory for Emergency and Critical Care Medicine, Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong Province, Qilu Hospital of Shandong University, Jinan, ChinaDepartment of Infection Control, Provincial Hospital of Shandong First Medical University, Jinan, Shandong, ChinaObjectiveThe study aimed to investigate the relationship between global tracheobronchial lung cancer mortality rates and economic levels and assess the associated regional economic burden. Understanding these associations is crucial for global health resource allocation, informing cancer prevention and control strategies, and providing data to support the development of lung cancer and economic policies worldwide.MethodsWe analyzed respiratory cancer mortality data (International Classification of Diseases (ICD)-10 codes C33-C34) obtained from the World Health Organization (WHO) Mortality Database (2000–2019). Age-standardized mortality rates (ASMRs) were calculated to describe the spatiotemporal distribution characteristics. Non-parametric comparisons (Wilcoxon rank-sum test) were performed to assess gender differences in mortality. Spearman’s partial rank correlation analysis was performed to evaluate the association between national income levels (World Bank classification) and disease mortality.ResultsThe core cohort included 50 countries with sufficient data. The global mean ASMR for respiratory cancers showed a decreasing trend from 2000 to 2019. Countries included in the Global Respiratory Tumor Mortality Registry System (GRTMRS) were predominantly high-income (68%) and European (52%). A significant positive correlation was observed between income levels and respiratory cancer mortality (Spearman’s ρ = 0.422, p < 0.001). ASMRs were consistently and significantly higher among male individuals than female individuals (Wilcoxon rank-sum test, p < 0.001).ConclusionBetween 2000 and 2019, global tracheobronchial lung cancer mortality appeared to be positively correlated with national economic level, particularly in high- and middle-income countries. Age-standardized mortality rates were significantly higher in male individuals than in female individuals. Paradoxically, these findings suggest that increasing economic development may be associated with elevated respiratory cancer mortality rates, emphasizing the critical need for balanced prevention strategies tailored to both high- and low-income settings.https://www.frontiersin.org/articles/10.3389/fpubh.2025.1647634/fullrespiratory tumormortality rateeconomicgender differenceformulation |
| spellingShingle | Mingjie Wang Mingjie Wang Zhiyuan Chen Global respiratory tumor mortality correlation study with economic level, 2000–2019 Frontiers in Public Health respiratory tumor mortality rate economic gender difference formulation |
| title | Global respiratory tumor mortality correlation study with economic level, 2000–2019 |
| title_full | Global respiratory tumor mortality correlation study with economic level, 2000–2019 |
| title_fullStr | Global respiratory tumor mortality correlation study with economic level, 2000–2019 |
| title_full_unstemmed | Global respiratory tumor mortality correlation study with economic level, 2000–2019 |
| title_short | Global respiratory tumor mortality correlation study with economic level, 2000–2019 |
| title_sort | global respiratory tumor mortality correlation study with economic level 2000 2019 |
| topic | respiratory tumor mortality rate economic gender difference formulation |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1647634/full |
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