Recent Glycemia Is a Major Determinant of β-Cell Function in Type 2 Diabetes Mellitus
Background Progressive deterioration of β-cell function is a characteristic of type 2 diabetes mellitus (T2DM). We aimed to investigate the relative contributions of clinical factors to β-cell function in T2DM. Methods In a T2DM cohort of 470 adults (disease duration 0 to 41 years), β-cell function...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Diabetes Association
2024-11-01
|
| Series: | Diabetes & Metabolism Journal |
| Subjects: | |
| Online Access: | http://e-dmj.org/upload/pdf/dmj-2023-0359.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846150044188672000 |
|---|---|
| author | Ji Yoon Kim Jiyoon Lee Sin Gon Kim Nam Hoon Kim |
| author_facet | Ji Yoon Kim Jiyoon Lee Sin Gon Kim Nam Hoon Kim |
| author_sort | Ji Yoon Kim |
| collection | DOAJ |
| description | Background Progressive deterioration of β-cell function is a characteristic of type 2 diabetes mellitus (T2DM). We aimed to investigate the relative contributions of clinical factors to β-cell function in T2DM. Methods In a T2DM cohort of 470 adults (disease duration 0 to 41 years), β-cell function was estimated using insulinogenic index (IGI), disposition index (DI), oral disposition index (DIO), and homeostasis model assessment of β-cell function (HOMA-B) derived from a 75 g oral glucose tolerance test (OGTT). The relative contributions of age, sex, disease duration, body mass index, glycosylated hemoglobin (HbA1c) levels (at the time of the OGTT), area under the curve of HbA1c over time (HbA1c AUC), coefficient of variation in HbA1c (HbA1c CV), and antidiabetic agents use were compared by standardized regression coefficients. Longitudinal analyses of these indices were also performed. Results IGI, DI, DIO, and HOMA-B declined over time (P<0.001 for all). Notably, HbA1c was the most significant factor affecting IGI, DI, DIO, and HOMA-B in the multivariable regression analysis. Compared with HbA1c ≥9%, DI was 1.9-, 2.5-, 3.7-, and 5.5-fold higher in HbA1c of 8%–<9%, 7%–<8%, 6%–<7%, and <6%, respectively, after adjusting for confounding factors (P<0.001). Conversely, β-cell function was not affected by the type or duration of antidiabetic agents, HbA1c AUC, or HbA1c CV. The trajectories of the IGI, DI, DIO, and HOMA-B mirrored those of HbA1c. Conclusion β-Cell function declines over time; however, it is flexible, being largely affected by recent glycemia in T2DM. |
| format | Article |
| id | doaj-art-9d442b86acff4b47a7d6bf77792ff991 |
| institution | Kabale University |
| issn | 2233-6079 2233-6087 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Korean Diabetes Association |
| record_format | Article |
| series | Diabetes & Metabolism Journal |
| spelling | doaj-art-9d442b86acff4b47a7d6bf77792ff9912024-11-29T06:51:01ZengKorean Diabetes AssociationDiabetes & Metabolism Journal2233-60792233-60872024-11-014861135114610.4093/dmj.2023.03592855Recent Glycemia Is a Major Determinant of β-Cell Function in Type 2 Diabetes MellitusJi Yoon Kim0Jiyoon Lee1Sin Gon Kim2Nam Hoon Kim3 Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, KoreaBackground Progressive deterioration of β-cell function is a characteristic of type 2 diabetes mellitus (T2DM). We aimed to investigate the relative contributions of clinical factors to β-cell function in T2DM. Methods In a T2DM cohort of 470 adults (disease duration 0 to 41 years), β-cell function was estimated using insulinogenic index (IGI), disposition index (DI), oral disposition index (DIO), and homeostasis model assessment of β-cell function (HOMA-B) derived from a 75 g oral glucose tolerance test (OGTT). The relative contributions of age, sex, disease duration, body mass index, glycosylated hemoglobin (HbA1c) levels (at the time of the OGTT), area under the curve of HbA1c over time (HbA1c AUC), coefficient of variation in HbA1c (HbA1c CV), and antidiabetic agents use were compared by standardized regression coefficients. Longitudinal analyses of these indices were also performed. Results IGI, DI, DIO, and HOMA-B declined over time (P<0.001 for all). Notably, HbA1c was the most significant factor affecting IGI, DI, DIO, and HOMA-B in the multivariable regression analysis. Compared with HbA1c ≥9%, DI was 1.9-, 2.5-, 3.7-, and 5.5-fold higher in HbA1c of 8%–<9%, 7%–<8%, 6%–<7%, and <6%, respectively, after adjusting for confounding factors (P<0.001). Conversely, β-cell function was not affected by the type or duration of antidiabetic agents, HbA1c AUC, or HbA1c CV. The trajectories of the IGI, DI, DIO, and HOMA-B mirrored those of HbA1c. Conclusion β-Cell function declines over time; however, it is flexible, being largely affected by recent glycemia in T2DM.http://e-dmj.org/upload/pdf/dmj-2023-0359.pdfdiabetes mellitus, type 2glycemic controlinsulin secretion |
| spellingShingle | Ji Yoon Kim Jiyoon Lee Sin Gon Kim Nam Hoon Kim Recent Glycemia Is a Major Determinant of β-Cell Function in Type 2 Diabetes Mellitus Diabetes & Metabolism Journal diabetes mellitus, type 2 glycemic control insulin secretion |
| title | Recent Glycemia Is a Major Determinant of β-Cell Function in Type 2 Diabetes Mellitus |
| title_full | Recent Glycemia Is a Major Determinant of β-Cell Function in Type 2 Diabetes Mellitus |
| title_fullStr | Recent Glycemia Is a Major Determinant of β-Cell Function in Type 2 Diabetes Mellitus |
| title_full_unstemmed | Recent Glycemia Is a Major Determinant of β-Cell Function in Type 2 Diabetes Mellitus |
| title_short | Recent Glycemia Is a Major Determinant of β-Cell Function in Type 2 Diabetes Mellitus |
| title_sort | recent glycemia is a major determinant of β cell function in type 2 diabetes mellitus |
| topic | diabetes mellitus, type 2 glycemic control insulin secretion |
| url | http://e-dmj.org/upload/pdf/dmj-2023-0359.pdf |
| work_keys_str_mv | AT jiyoonkim recentglycemiaisamajordeterminantofbcellfunctionintype2diabetesmellitus AT jiyoonlee recentglycemiaisamajordeterminantofbcellfunctionintype2diabetesmellitus AT singonkim recentglycemiaisamajordeterminantofbcellfunctionintype2diabetesmellitus AT namhoonkim recentglycemiaisamajordeterminantofbcellfunctionintype2diabetesmellitus |