A narrative review focusing on randomized clinical trials of vitamin D supplementation for COVID-19 disease
Current evidence is inconsistent on whether vitamin D supplementation can prevent COVID-19 infection or improve its clinical outcomes. To better understand and look into the issue, we went through the background knowledge of COVID-19 and vitamin D, searched in Pubmed [by using key words in the title...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1461485/full |
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| author | Limi Huang Zhiwei Song Chaosheng Lu Shenwen Wang Changsheng Guo Xin-He Lai Xin-He Lai Zhenfeng Zhao |
| author_facet | Limi Huang Zhiwei Song Chaosheng Lu Shenwen Wang Changsheng Guo Xin-He Lai Xin-He Lai Zhenfeng Zhao |
| author_sort | Limi Huang |
| collection | DOAJ |
| description | Current evidence is inconsistent on whether vitamin D supplementation can prevent COVID-19 infection or improve its clinical outcomes. To better understand and look into the issue, we went through the background knowledge of COVID-19 and vitamin D, searched in Pubmed [by using key words in the title containing “randomized clinical trial”, “COVID-19”, and “vitamin D (25-hydroxyvitamin D, or cholecalciferol, or calcidiol, or calcifediol) supplementation”] for publications of studies on vitamin D/supplementation in COVID-19 patients, especially those about the randomized clinical trials (RCTs). After reviewing these papers, we did a short background review of vitamin D and the pathophysiology of COVID-19, summarized the key features of the 25 RCTs in text and tabulated in a table of some of the features, commented, compared and discussed the differences between RCTs (for example, change the serum 25-hydroxyvitamin D concentration from nmol/L to ng/mL, making the comparison easier). The take-home question of the review is that serum 25-hydroxyvitamin D concentration is an important indicator of the supplementation effect of vitamin D correction but may not be reliable in predicting the supplementation effect on the clinical outcomes of COVID-19. |
| format | Article |
| id | doaj-art-9d3693ade1b34d84ad53c219cc2f551f |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-9d3693ade1b34d84ad53c219cc2f551f2025-01-07T04:12:55ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-01-011110.3389/fnut.2024.14614851461485A narrative review focusing on randomized clinical trials of vitamin D supplementation for COVID-19 diseaseLimi Huang0Zhiwei Song1Chaosheng Lu2Shenwen Wang3Changsheng Guo4Xin-He Lai5Xin-He Lai6Zhenfeng Zhao7Department of Pediatrics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Infection Diseases, Xianju County People's Hospital, Taizhou, Zhejiang, ChinaDepartment of Pediatrics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaSchool of Information Engineering, Hebei GEO University, Shijiazhuang, Hebei, ChinaShaoxing BWK Biotechnology Co., Ltd., Zhuji City High-Tech Entrepreneurship Center, Shaoxing, Zhejiang, ChinaDepartment of Pediatrics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaShenzhen Boya Gene Technology Co., Ltd., Shenzhen, ChinaHebei Huiji Technology Co., Ltd., Shijiazhuang, Hebei, ChinaCurrent evidence is inconsistent on whether vitamin D supplementation can prevent COVID-19 infection or improve its clinical outcomes. To better understand and look into the issue, we went through the background knowledge of COVID-19 and vitamin D, searched in Pubmed [by using key words in the title containing “randomized clinical trial”, “COVID-19”, and “vitamin D (25-hydroxyvitamin D, or cholecalciferol, or calcidiol, or calcifediol) supplementation”] for publications of studies on vitamin D/supplementation in COVID-19 patients, especially those about the randomized clinical trials (RCTs). After reviewing these papers, we did a short background review of vitamin D and the pathophysiology of COVID-19, summarized the key features of the 25 RCTs in text and tabulated in a table of some of the features, commented, compared and discussed the differences between RCTs (for example, change the serum 25-hydroxyvitamin D concentration from nmol/L to ng/mL, making the comparison easier). The take-home question of the review is that serum 25-hydroxyvitamin D concentration is an important indicator of the supplementation effect of vitamin D correction but may not be reliable in predicting the supplementation effect on the clinical outcomes of COVID-19.https://www.frontiersin.org/articles/10.3389/fnut.2024.1461485/fullrandomized clinical trialvitamin Dsevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)COVID-19serum 25-hydroxyvitamin D |
| spellingShingle | Limi Huang Zhiwei Song Chaosheng Lu Shenwen Wang Changsheng Guo Xin-He Lai Xin-He Lai Zhenfeng Zhao A narrative review focusing on randomized clinical trials of vitamin D supplementation for COVID-19 disease Frontiers in Nutrition randomized clinical trial vitamin D severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) COVID-19 serum 25-hydroxyvitamin D |
| title | A narrative review focusing on randomized clinical trials of vitamin D supplementation for COVID-19 disease |
| title_full | A narrative review focusing on randomized clinical trials of vitamin D supplementation for COVID-19 disease |
| title_fullStr | A narrative review focusing on randomized clinical trials of vitamin D supplementation for COVID-19 disease |
| title_full_unstemmed | A narrative review focusing on randomized clinical trials of vitamin D supplementation for COVID-19 disease |
| title_short | A narrative review focusing on randomized clinical trials of vitamin D supplementation for COVID-19 disease |
| title_sort | narrative review focusing on randomized clinical trials of vitamin d supplementation for covid 19 disease |
| topic | randomized clinical trial vitamin D severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) COVID-19 serum 25-hydroxyvitamin D |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1461485/full |
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