Date seeds powder alleviate the aflatoxin B1 provoked heart toxicity in male offspring rat
Abstract Date (Phoenix dactylifera L.) seeds (PDL) have recently evoked significant attention for their therapeutic potential against numerous diseases. Aflatoxin B1 (AFB1) is an inevitable environmental hazard that pollutes foods and may harm the heart. This study investigated the beneficial effect...
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Nature Portfolio
2024-12-01
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| Online Access: | https://doi.org/10.1038/s41598-024-80197-5 |
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| author | Heba M. A. Khalil Walaa A. M. Eid Mohammad El-Nablaway Eman Mohamad El Nashar Jaber Saad Al-tarish Hanan M. A. El Henafy |
| author_facet | Heba M. A. Khalil Walaa A. M. Eid Mohammad El-Nablaway Eman Mohamad El Nashar Jaber Saad Al-tarish Hanan M. A. El Henafy |
| author_sort | Heba M. A. Khalil |
| collection | DOAJ |
| description | Abstract Date (Phoenix dactylifera L.) seeds (PDL) have recently evoked significant attention for their therapeutic potential against numerous diseases. Aflatoxin B1 (AFB1) is an inevitable environmental hazard that pollutes foods and may harm the heart. This study investigated the beneficial effect of PDL against cardiac toxicity induced by AFB1 in male offspring. Female albino rats received PDL (200 mg/kg) orally for 14 days before mating till weaning and AFB1 (50 μg/kg) intramuscularly throughout gestation and lactation. At postnatal day 60, male offspring hearts were collected. Compared to AFB1 intoxicated group, PDL-treated offspring displayed improved cardiac biomarkers, an increase in their antioxidant defense, and a decrease in the cardiac proinflammatory cytokines. Additionally, a reduction in the expression levels of Bcl2 and Nrf2 was observed, with genes linked to increased cardiac caspase-3, Bax, ACE1, P53, and cytochrome C levels. In conclusion, PDL acts as a potential adjuvant agent for ameliorating cardiac toxicity and apoptosis resulting from exposure to AFB1. This is attributed to its antioxidative and anti-inflammatory effects, as well as its capacity to sequester free radicals within cardiac tissue. |
| format | Article |
| id | doaj-art-9d24b515f5ab4757a72c5a57b2ea957b |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-9d24b515f5ab4757a72c5a57b2ea957b2024-12-22T12:27:03ZengNature PortfolioScientific Reports2045-23222024-12-0114111710.1038/s41598-024-80197-5Date seeds powder alleviate the aflatoxin B1 provoked heart toxicity in male offspring ratHeba M. A. Khalil0Walaa A. M. Eid1Mohammad El-Nablaway2Eman Mohamad El Nashar3Jaber Saad Al-tarish4Hanan M. A. El Henafy5Department of Veterinary Hygiene and Management, Faculty of Veterinary Medicine, Cairo UniversityFood Science and Technology Department, Faculty of Agriculture, New Valley UniversityDepartment of Basic Medical Sciences, College of Medicine, AlMaarefa UniversityDepartment of Anatomy, College Medicine, King Khalid UniversityMinistry of Health Saudi Arabia, Senior Pharmacist-Ministry of HealthTechnology of Medical Laboratory Department, Faculty of Technology of Applied Health Sciences, October 6 UniversityAbstract Date (Phoenix dactylifera L.) seeds (PDL) have recently evoked significant attention for their therapeutic potential against numerous diseases. Aflatoxin B1 (AFB1) is an inevitable environmental hazard that pollutes foods and may harm the heart. This study investigated the beneficial effect of PDL against cardiac toxicity induced by AFB1 in male offspring. Female albino rats received PDL (200 mg/kg) orally for 14 days before mating till weaning and AFB1 (50 μg/kg) intramuscularly throughout gestation and lactation. At postnatal day 60, male offspring hearts were collected. Compared to AFB1 intoxicated group, PDL-treated offspring displayed improved cardiac biomarkers, an increase in their antioxidant defense, and a decrease in the cardiac proinflammatory cytokines. Additionally, a reduction in the expression levels of Bcl2 and Nrf2 was observed, with genes linked to increased cardiac caspase-3, Bax, ACE1, P53, and cytochrome C levels. In conclusion, PDL acts as a potential adjuvant agent for ameliorating cardiac toxicity and apoptosis resulting from exposure to AFB1. This is attributed to its antioxidative and anti-inflammatory effects, as well as its capacity to sequester free radicals within cardiac tissue.https://doi.org/10.1038/s41598-024-80197-5Phoenix dactylifera L. seedsAflatoxin B1Oxidative stressHeart toxicityPro-inflammatory cytokinesAntioxidant |
| spellingShingle | Heba M. A. Khalil Walaa A. M. Eid Mohammad El-Nablaway Eman Mohamad El Nashar Jaber Saad Al-tarish Hanan M. A. El Henafy Date seeds powder alleviate the aflatoxin B1 provoked heart toxicity in male offspring rat Scientific Reports Phoenix dactylifera L. seeds Aflatoxin B1 Oxidative stress Heart toxicity Pro-inflammatory cytokines Antioxidant |
| title | Date seeds powder alleviate the aflatoxin B1 provoked heart toxicity in male offspring rat |
| title_full | Date seeds powder alleviate the aflatoxin B1 provoked heart toxicity in male offspring rat |
| title_fullStr | Date seeds powder alleviate the aflatoxin B1 provoked heart toxicity in male offspring rat |
| title_full_unstemmed | Date seeds powder alleviate the aflatoxin B1 provoked heart toxicity in male offspring rat |
| title_short | Date seeds powder alleviate the aflatoxin B1 provoked heart toxicity in male offspring rat |
| title_sort | date seeds powder alleviate the aflatoxin b1 provoked heart toxicity in male offspring rat |
| topic | Phoenix dactylifera L. seeds Aflatoxin B1 Oxidative stress Heart toxicity Pro-inflammatory cytokines Antioxidant |
| url | https://doi.org/10.1038/s41598-024-80197-5 |
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