Advances in the study of posttranslational modifications of histones in head and neck squamous cell carcinoma
Abstract The pathogenesis of head and neck squamous cell carcinoma (HNSCC) is notably complex. Early symptoms are often subtle, and effective early screening methods are currently lacking. The tumors associated with HNSCC develop rapidly, exhibit high aggressiveness, and respond poorly to existing t...
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| Format: | Article |
| Language: | English |
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BMC
2024-11-01
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| Series: | Clinical Epigenetics |
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| Online Access: | https://doi.org/10.1186/s13148-024-01785-w |
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| author | Yuyang Xiao Yikai Zhang Yuyang Hu Xupeng Zhang Jiaqi Tan Shanhu Yao Xingwei Wang Yuexiang Qin |
| author_facet | Yuyang Xiao Yikai Zhang Yuyang Hu Xupeng Zhang Jiaqi Tan Shanhu Yao Xingwei Wang Yuexiang Qin |
| author_sort | Yuyang Xiao |
| collection | DOAJ |
| description | Abstract The pathogenesis of head and neck squamous cell carcinoma (HNSCC) is notably complex. Early symptoms are often subtle, and effective early screening methods are currently lacking. The tumors associated with HNSCC develop rapidly, exhibit high aggressiveness, and respond poorly to existing treatments, leading to low survival rates and poor prognosis. Numerous studies have demonstrated that histone posttranslational modifications (HPTMs), including acetylation, methylation, phosphorylation, and ubiquitination, play a critical role in the occurrence and progression of HNSCC. Moreover, targeting histone posttranslationally modified molecules with specific drugs has shown potential in enhancing therapeutic outcomes and improving prognosis, underscoring their significant clinical value. This review aims to summarize the role of histone posttranslational modifications in the pathogenesis and progression of HNSCC and to discuss their clinical significance, thereby providing insights into novel therapeutic approaches and drug development for this malignancy. |
| format | Article |
| id | doaj-art-9d1ce3edefa3418a93f66f58833c8bb3 |
| institution | Kabale University |
| issn | 1868-7083 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Clinical Epigenetics |
| spelling | doaj-art-9d1ce3edefa3418a93f66f58833c8bb32024-11-24T12:31:05ZengBMCClinical Epigenetics1868-70832024-11-0116111510.1186/s13148-024-01785-wAdvances in the study of posttranslational modifications of histones in head and neck squamous cell carcinomaYuyang Xiao0Yikai Zhang1Yuyang Hu2Xupeng Zhang3Jiaqi Tan4Shanhu Yao5Xingwei Wang6Yuexiang Qin7Department of Health Management Medical, The Third Xiangya Hospital of Central South UniversityDepartment of Health Management Medical, The Third Xiangya Hospital of Central South UniversityDepartment of Health Management Medical, The Third Xiangya Hospital of Central South UniversityDepartment of Health Management Medical, The Third Xiangya Hospital of Central South UniversityDepartment of Otolaryngology, Head and Neck Surgery, Xiangya Hospital, Central South UniversityDepartment of Radiology, The Third Xiangya Hospital, Central South UniversityDepartment of Otolaryngology, Head and Neck Surgery, Xiangya Hospital, Central South UniversityDepartment of Health Management Medical, The Third Xiangya Hospital of Central South UniversityAbstract The pathogenesis of head and neck squamous cell carcinoma (HNSCC) is notably complex. Early symptoms are often subtle, and effective early screening methods are currently lacking. The tumors associated with HNSCC develop rapidly, exhibit high aggressiveness, and respond poorly to existing treatments, leading to low survival rates and poor prognosis. Numerous studies have demonstrated that histone posttranslational modifications (HPTMs), including acetylation, methylation, phosphorylation, and ubiquitination, play a critical role in the occurrence and progression of HNSCC. Moreover, targeting histone posttranslationally modified molecules with specific drugs has shown potential in enhancing therapeutic outcomes and improving prognosis, underscoring their significant clinical value. This review aims to summarize the role of histone posttranslational modifications in the pathogenesis and progression of HNSCC and to discuss their clinical significance, thereby providing insights into novel therapeutic approaches and drug development for this malignancy.https://doi.org/10.1186/s13148-024-01785-wHead and neck squamous cell carcinomaEpigeneticsHistone posttranslational modificationsHistone inhibitors |
| spellingShingle | Yuyang Xiao Yikai Zhang Yuyang Hu Xupeng Zhang Jiaqi Tan Shanhu Yao Xingwei Wang Yuexiang Qin Advances in the study of posttranslational modifications of histones in head and neck squamous cell carcinoma Clinical Epigenetics Head and neck squamous cell carcinoma Epigenetics Histone posttranslational modifications Histone inhibitors |
| title | Advances in the study of posttranslational modifications of histones in head and neck squamous cell carcinoma |
| title_full | Advances in the study of posttranslational modifications of histones in head and neck squamous cell carcinoma |
| title_fullStr | Advances in the study of posttranslational modifications of histones in head and neck squamous cell carcinoma |
| title_full_unstemmed | Advances in the study of posttranslational modifications of histones in head and neck squamous cell carcinoma |
| title_short | Advances in the study of posttranslational modifications of histones in head and neck squamous cell carcinoma |
| title_sort | advances in the study of posttranslational modifications of histones in head and neck squamous cell carcinoma |
| topic | Head and neck squamous cell carcinoma Epigenetics Histone posttranslational modifications Histone inhibitors |
| url | https://doi.org/10.1186/s13148-024-01785-w |
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