Renal Ultrastructural Alterations Induced by Lead Acetate and Protective Effects of Ginseng
Background: Lead is a hazardous metal that has a variety of physiological, behavioral, and biochemical impacts on people. Lead poisoning is the most common type of heavy metal poisoning. This work was designed to evaluate ginseng's potential cytoprotective effects in a model of lead acetate-ind...
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International Medical Research and Development Corporation
2024-12-01
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| Series: | International Journal of Biomedicine |
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| Online Access: | http://www.ijbm.org/articles/i56/ijbm_14(4)_oa28.pdf |
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| author | Ali Hassan A. Ali Ali Al-Gonaim Saad Alqasem Omar Alanazi |
| author_facet | Ali Hassan A. Ali Ali Al-Gonaim Saad Alqasem Omar Alanazi |
| author_sort | Ali Hassan A. Ali |
| collection | DOAJ |
| description | Background: Lead is a hazardous metal that has a variety of physiological, behavioral, and biochemical impacts on people. Lead poisoning is the most common type of heavy metal poisoning. This work was designed to evaluate ginseng's potential cytoprotective effects in a model of lead acetate-induced nephrotoxicity and to explore the specific pathways related to the involvement of oxidative stress, mitochondria, and apoptosis in this process.
Methods and Results: For the study, 21 healthy 10-week-old albino rats weighing between 250 g and 310 g were used. The rats were split into three groups, each group consisting of seven rats. Group 1 (control group) included rats that did not receive medicine and were given distilled water orally and regularly. Group 2 included rats given 10mg/kg of lead acetate via gastric gavage once a day for 28 days. Group 3 included rats given, via gastric gavage, 10mg/kg of lead acetate once a day for 28 days and 100mg/kg of ginseng dissolved in 1 ml of distilled water.
On the designated day, the animals were anesthetized with ether inhalation, and kidneys were removed through a median abdominal incision. The kidney specimens were cut into serial semi-thin sections and prepared for electron microscopy and transmission electron microscopy. Albino rats exposed to lead acetate experienced changes in the ultrastructure of their renal cortex. Treatment with ginseng dramatically reduced tubular damage, cell apoptosis, and necrotic and degenerative changes.
Conclusion: According to our findings, ginseng may shield the kidneys from the harmful effects of lead. |
| format | Article |
| id | doaj-art-9d10c9de2d4f47b09d0ab0e2a551594e |
| institution | Kabale University |
| issn | 2158-0510 2158-0529 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | International Medical Research and Development Corporation |
| record_format | Article |
| series | International Journal of Biomedicine |
| spelling | doaj-art-9d10c9de2d4f47b09d0ab0e2a551594e2024-12-07T05:56:15ZengInternational Medical Research and Development CorporationInternational Journal of Biomedicine2158-05102158-05292024-12-0114470470810.21103/Article14(4)_OA28Renal Ultrastructural Alterations Induced by Lead Acetate and Protective Effects of GinsengAli Hassan A. Ali0Ali Al-Gonaim1Saad Alqasem2Omar Alanazi3Basic Medical Science Department, College of Medicine, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, KSA; Anatomy Department, Faculty of Medicine, Al-Azhar University, Cairo, EgyptSurgery Department, College of medicine, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, KSASurgery Department, College of medicine, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, KSACollege of Medicine, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, KSABackground: Lead is a hazardous metal that has a variety of physiological, behavioral, and biochemical impacts on people. Lead poisoning is the most common type of heavy metal poisoning. This work was designed to evaluate ginseng's potential cytoprotective effects in a model of lead acetate-induced nephrotoxicity and to explore the specific pathways related to the involvement of oxidative stress, mitochondria, and apoptosis in this process. Methods and Results: For the study, 21 healthy 10-week-old albino rats weighing between 250 g and 310 g were used. The rats were split into three groups, each group consisting of seven rats. Group 1 (control group) included rats that did not receive medicine and were given distilled water orally and regularly. Group 2 included rats given 10mg/kg of lead acetate via gastric gavage once a day for 28 days. Group 3 included rats given, via gastric gavage, 10mg/kg of lead acetate once a day for 28 days and 100mg/kg of ginseng dissolved in 1 ml of distilled water. On the designated day, the animals were anesthetized with ether inhalation, and kidneys were removed through a median abdominal incision. The kidney specimens were cut into serial semi-thin sections and prepared for electron microscopy and transmission electron microscopy. Albino rats exposed to lead acetate experienced changes in the ultrastructure of their renal cortex. Treatment with ginseng dramatically reduced tubular damage, cell apoptosis, and necrotic and degenerative changes. Conclusion: According to our findings, ginseng may shield the kidneys from the harmful effects of lead.http://www.ijbm.org/articles/i56/ijbm_14(4)_oa28.pdfkidneyrenal tubulesnephrotoxicitylead acetateoxidative stressginseng |
| spellingShingle | Ali Hassan A. Ali Ali Al-Gonaim Saad Alqasem Omar Alanazi Renal Ultrastructural Alterations Induced by Lead Acetate and Protective Effects of Ginseng International Journal of Biomedicine kidney renal tubules nephrotoxicity lead acetate oxidative stress ginseng |
| title | Renal Ultrastructural Alterations Induced by Lead Acetate and Protective Effects of Ginseng |
| title_full | Renal Ultrastructural Alterations Induced by Lead Acetate and Protective Effects of Ginseng |
| title_fullStr | Renal Ultrastructural Alterations Induced by Lead Acetate and Protective Effects of Ginseng |
| title_full_unstemmed | Renal Ultrastructural Alterations Induced by Lead Acetate and Protective Effects of Ginseng |
| title_short | Renal Ultrastructural Alterations Induced by Lead Acetate and Protective Effects of Ginseng |
| title_sort | renal ultrastructural alterations induced by lead acetate and protective effects of ginseng |
| topic | kidney renal tubules nephrotoxicity lead acetate oxidative stress ginseng |
| url | http://www.ijbm.org/articles/i56/ijbm_14(4)_oa28.pdf |
| work_keys_str_mv | AT alihassanaali renalultrastructuralalterationsinducedbyleadacetateandprotectiveeffectsofginseng AT alialgonaim renalultrastructuralalterationsinducedbyleadacetateandprotectiveeffectsofginseng AT saadalqasem renalultrastructuralalterationsinducedbyleadacetateandprotectiveeffectsofginseng AT omaralanazi renalultrastructuralalterationsinducedbyleadacetateandprotectiveeffectsofginseng |