Intracellular α-synuclein assemblies are sufficient to alter nanoscale diffusion in the striatal extracellular space
Abstract α-synucleinopathies progression involves the spread of α-synuclein aggregates through the extracellular space (ECS). Single-particle tracking studies showed that α-synuclein-induced neurodegeneration increases ECS molecular diffusivity. To disentangle the consequences of neuronal loss versu...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-12-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-024-00850-8 |
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| author | J. Estaun-Panzano S. Nandi Q. Gresil E. Doudnikoff C. Mazzocco ML. Arotcarena MH. Canron B. Dehay L. Cognet E. Bezard |
| author_facet | J. Estaun-Panzano S. Nandi Q. Gresil E. Doudnikoff C. Mazzocco ML. Arotcarena MH. Canron B. Dehay L. Cognet E. Bezard |
| author_sort | J. Estaun-Panzano |
| collection | DOAJ |
| description | Abstract α-synucleinopathies progression involves the spread of α-synuclein aggregates through the extracellular space (ECS). Single-particle tracking studies showed that α-synuclein-induced neurodegeneration increases ECS molecular diffusivity. To disentangle the consequences of neuronal loss versus α-synuclein-positive intracellular assemblies formation, we performed near-infrared single-particle tracking to characterise ECS rheology in the striatum of mouse models of α-synucleinopathies. We showed that intracellular α-synuclein assemblies, without neurodegeneration, suffice to alter nanoscale diffusion in the striatal ECS. |
| format | Article |
| id | doaj-art-9d0dc93641da46418121a8c4463f77d1 |
| institution | Kabale University |
| issn | 2373-8057 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj-art-9d0dc93641da46418121a8c4463f77d12025-01-05T12:12:00ZengNature Portfolionpj Parkinson's Disease2373-80572024-12-011011710.1038/s41531-024-00850-8Intracellular α-synuclein assemblies are sufficient to alter nanoscale diffusion in the striatal extracellular spaceJ. Estaun-Panzano0S. Nandi1Q. Gresil2E. Doudnikoff3C. Mazzocco4ML. Arotcarena5MH. Canron6B. Dehay7L. Cognet8E. Bezard9Univ. Bordeaux, CNRS, Institut des Maladies Neurodégénératives, UMR 5293Univ. Bordeaux, CNRS, Laboratoire Photonique, Numérique et Nanosciences, UMR 5298Univ. Bordeaux, CNRS, Laboratoire Photonique, Numérique et Nanosciences, UMR 5298Univ. Bordeaux, CNRS, Institut des Maladies Neurodégénératives, UMR 5293Univ. Bordeaux, CNRS, Institut des Maladies Neurodégénératives, UMR 5293Univ. Bordeaux, CNRS, Institut des Maladies Neurodégénératives, UMR 5293Univ. Bordeaux, CNRS, Institut des Maladies Neurodégénératives, UMR 5293Univ. Bordeaux, CNRS, Institut des Maladies Neurodégénératives, UMR 5293Univ. Bordeaux, CNRS, Laboratoire Photonique, Numérique et Nanosciences, UMR 5298Univ. Bordeaux, CNRS, Institut des Maladies Neurodégénératives, UMR 5293Abstract α-synucleinopathies progression involves the spread of α-synuclein aggregates through the extracellular space (ECS). Single-particle tracking studies showed that α-synuclein-induced neurodegeneration increases ECS molecular diffusivity. To disentangle the consequences of neuronal loss versus α-synuclein-positive intracellular assemblies formation, we performed near-infrared single-particle tracking to characterise ECS rheology in the striatum of mouse models of α-synucleinopathies. We showed that intracellular α-synuclein assemblies, without neurodegeneration, suffice to alter nanoscale diffusion in the striatal ECS.https://doi.org/10.1038/s41531-024-00850-8 |
| spellingShingle | J. Estaun-Panzano S. Nandi Q. Gresil E. Doudnikoff C. Mazzocco ML. Arotcarena MH. Canron B. Dehay L. Cognet E. Bezard Intracellular α-synuclein assemblies are sufficient to alter nanoscale diffusion in the striatal extracellular space npj Parkinson's Disease |
| title | Intracellular α-synuclein assemblies are sufficient to alter nanoscale diffusion in the striatal extracellular space |
| title_full | Intracellular α-synuclein assemblies are sufficient to alter nanoscale diffusion in the striatal extracellular space |
| title_fullStr | Intracellular α-synuclein assemblies are sufficient to alter nanoscale diffusion in the striatal extracellular space |
| title_full_unstemmed | Intracellular α-synuclein assemblies are sufficient to alter nanoscale diffusion in the striatal extracellular space |
| title_short | Intracellular α-synuclein assemblies are sufficient to alter nanoscale diffusion in the striatal extracellular space |
| title_sort | intracellular α synuclein assemblies are sufficient to alter nanoscale diffusion in the striatal extracellular space |
| url | https://doi.org/10.1038/s41531-024-00850-8 |
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