Venous Thromboembolic Complications in Patients with Acute Chemical Poisoning
RELEVANCE. Venous thromboembolic complications (VTEC) occur in patients hospitalized with various pathologies, complicate treatment and increase mortality. This problem has not received enough attention in toxicology.AIM OF THE STUDY. Conduct an analysis of VTEC in patients with acute chemical poiso...
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Sklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare Department
2024-10-01
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| Series: | Неотложная медицинская помощь |
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| Online Access: | https://www.jnmp.ru/jour/article/view/1928 |
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| author | M. V. Belova K. K. Ilyashenko G. N. Sukhodolova E. V. Kungurtsev A. V. Polunin M. M. Potskhveriya A. Yu. Simonova |
| author_facet | M. V. Belova K. K. Ilyashenko G. N. Sukhodolova E. V. Kungurtsev A. V. Polunin M. M. Potskhveriya A. Yu. Simonova |
| author_sort | M. V. Belova |
| collection | DOAJ |
| description | RELEVANCE. Venous thromboembolic complications (VTEC) occur in patients hospitalized with various pathologies, complicate treatment and increase mortality. This problem has not received enough attention in toxicology.AIM OF THE STUDY. Conduct an analysis of VTEC in patients with acute chemical poisoning (AP).MATERIAL AND METHODS. The hospital patient records and pathological examination reports of 670 patients of the N.V. Sklifosovsky Research Institute for Emergency Medicine who died from VTEC in the period 2016–2022 were retrospectively analyzed. VTEC were confirmed by Doppler ultrasound during life or during pathological examination. Statistical analysis of the data was performed using the IBM computer program SPSS Statistics 26.0.RESULTS. VTEC were diagnosed in 245 patients. The proportion of VTEC increased from 20.2 to 46.7% over the years, and in cases of VTEC caused by psychopharmacological drugs, they were registered in 48.8% of cases. VTEC occurred twice more often in people over 60 years of age and 1.3-fold more often in women. Deep vein thrombosis of the right lower limb was predominant in all types of poisoning, and the prevalence of the lesion was mainly local. Concomitant cardiovascular diseases, oncological diseases, diabetes mellitus, and the development of pneumonia increased the risk of VTEC. Pulmonary embolism was observed in more than a third of cases of VTEC in patients with VTEC caused by psychopharmacological drugs, corrosive substances, and hypotensive and antiarrhythmic drugs.CONCLUSIONS. The characteristics of venous thromboembolic complications in acute chemical poisoning in general is similar to the complications indicated that arise in other pathologies, but has some features caused by the effect of specific chemicals on the body. |
| format | Article |
| id | doaj-art-9cd429f6d4a24d92ae8ba7c32726d655 |
| institution | Kabale University |
| issn | 2223-9022 2541-8017 |
| language | Russian |
| publishDate | 2024-10-01 |
| publisher | Sklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare Department |
| record_format | Article |
| series | Неотложная медицинская помощь |
| spelling | doaj-art-9cd429f6d4a24d92ae8ba7c32726d6552025-08-20T03:56:36ZrusSklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare DepartmentНеотложная медицинская помощь2223-90222541-80172024-10-0113341942610.23934/2223-9022-2024-13-3-419-426962Venous Thromboembolic Complications in Patients with Acute Chemical PoisoningM. V. Belova0K. K. Ilyashenko1G. N. Sukhodolova2E. V. Kungurtsev3A. V. Polunin4M. M. Potskhveriya5A. Yu. Simonova6N.V. Sklifosovsky Research Institute for Emergency Medicine; Russian Medical Academy of Continuous Professional Education; I.M. Sechenov First Moscow State Medical University (Sechenov University)N.V. Sklifosovsky Research Institute for Emergency Medicine; Lopukhin Federal Research and Clinical Center of Physical-Chemical MedicineN.V. Sklifosovsky Research Institute for Emergency Medicine; Lopukhin Federal Research and Clinical Center of Physical-Chemical MedicineN.V. Sklifosovsky Research Institute for Emergency MedicineN.V. Sklifosovsky Research Institute for Emergency MedicineN.V. Sklifosovsky Research Institute for Emergency Medicine; Russian Medical Academy of Continuous Professional EducationN.V. Sklifosovsky Research Institute for Emergency Medicine; Russian Medical Academy of Continuous Professional Education; Lopukhin Federal Research and Clinical Center of Physical-Chemical MedicineRELEVANCE. Venous thromboembolic complications (VTEC) occur in patients hospitalized with various pathologies, complicate treatment and increase mortality. This problem has not received enough attention in toxicology.AIM OF THE STUDY. Conduct an analysis of VTEC in patients with acute chemical poisoning (AP).MATERIAL AND METHODS. The hospital patient records and pathological examination reports of 670 patients of the N.V. Sklifosovsky Research Institute for Emergency Medicine who died from VTEC in the period 2016–2022 were retrospectively analyzed. VTEC were confirmed by Doppler ultrasound during life or during pathological examination. Statistical analysis of the data was performed using the IBM computer program SPSS Statistics 26.0.RESULTS. VTEC were diagnosed in 245 patients. The proportion of VTEC increased from 20.2 to 46.7% over the years, and in cases of VTEC caused by psychopharmacological drugs, they were registered in 48.8% of cases. VTEC occurred twice more often in people over 60 years of age and 1.3-fold more often in women. Deep vein thrombosis of the right lower limb was predominant in all types of poisoning, and the prevalence of the lesion was mainly local. Concomitant cardiovascular diseases, oncological diseases, diabetes mellitus, and the development of pneumonia increased the risk of VTEC. Pulmonary embolism was observed in more than a third of cases of VTEC in patients with VTEC caused by psychopharmacological drugs, corrosive substances, and hypotensive and antiarrhythmic drugs.CONCLUSIONS. The characteristics of venous thromboembolic complications in acute chemical poisoning in general is similar to the complications indicated that arise in other pathologies, but has some features caused by the effect of specific chemicals on the body.https://www.jnmp.ru/jour/article/view/1928venous thromboembolic complicationspulmonary embolismacute chemical poisoningpsychopharmacological drugsantihypertensive and antiarrhythmic agentscorrosive substances |
| spellingShingle | M. V. Belova K. K. Ilyashenko G. N. Sukhodolova E. V. Kungurtsev A. V. Polunin M. M. Potskhveriya A. Yu. Simonova Venous Thromboembolic Complications in Patients with Acute Chemical Poisoning Неотложная медицинская помощь venous thromboembolic complications pulmonary embolism acute chemical poisoning psychopharmacological drugs antihypertensive and antiarrhythmic agents corrosive substances |
| title | Venous Thromboembolic Complications in Patients with Acute Chemical Poisoning |
| title_full | Venous Thromboembolic Complications in Patients with Acute Chemical Poisoning |
| title_fullStr | Venous Thromboembolic Complications in Patients with Acute Chemical Poisoning |
| title_full_unstemmed | Venous Thromboembolic Complications in Patients with Acute Chemical Poisoning |
| title_short | Venous Thromboembolic Complications in Patients with Acute Chemical Poisoning |
| title_sort | venous thromboembolic complications in patients with acute chemical poisoning |
| topic | venous thromboembolic complications pulmonary embolism acute chemical poisoning psychopharmacological drugs antihypertensive and antiarrhythmic agents corrosive substances |
| url | https://www.jnmp.ru/jour/article/view/1928 |
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