Clinical and Laboratory Profile of COVID-19 Patients Admitted at a Tertiary Care Center in New Delhi and Assessment of Factors Predicting Disease Severity
Background: This study was conducted in nonintensive care unit COVID-19 patients admitted in a tertiary care center, to assess the clinical profile and find surrogate markers to predict the severity of COVID-19 at the time of admission. Methodology: It is a cross-sectional observational study. Clini...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-04-01
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| Series: | Indian Journal of Medical Specialities |
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| Online Access: | https://journals.lww.com/10.4103/injms.injms_158_20 |
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| author | Piyush Jain Nitin Sinha M. K. Hari Prasad Vaibhav Padole |
| author_facet | Piyush Jain Nitin Sinha M. K. Hari Prasad Vaibhav Padole |
| author_sort | Piyush Jain |
| collection | DOAJ |
| description | Background:
This study was conducted in nonintensive care unit COVID-19 patients admitted in a tertiary care center, to assess the clinical profile and find surrogate markers to predict the severity of COVID-19 at the time of admission.
Methodology:
It is a cross-sectional observational study. Clinical and laboratory data were compiled of patients admitted in COVID wards in a tertiary care center. Patients were stratified clinically according to the severity of COVID pneumonia. The admission clinical and laboratory parameters were compared between the severe and nonsevere COVID patients.
Results:
The study included 63 patients of which 46 were males, with a mean age of 47 years. Patients were classified into mild (32%), moderate (19%), and severe (49%) categories according to national guidelines. Fever (81%), cough (67%), and dyspnea (67%) were the most commonly observed symptoms. In comparative analysis, mean C-reactive protein (CRP), serum ferritin, and neutrophil–lymphocyte ratio (NLR) were significantly higher in severe COVID-19 patients and the admission PaCO2 significantly lower compared to nonsevere patients.
Conclusion:
The study shows that raised NLR, CRP, serum ferritin, and low PaCO2 levels at the time of admission are important predictors of disease severity. |
| format | Article |
| id | doaj-art-9cd32b3bbda04a2f9dfdd6ed50e0db26 |
| institution | Kabale University |
| issn | 0976-2884 0976-2892 |
| language | English |
| publishDate | 2021-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Medical Specialities |
| spelling | doaj-art-9cd32b3bbda04a2f9dfdd6ed50e0db262025-08-25T08:33:51ZengWolters Kluwer Medknow PublicationsIndian Journal of Medical Specialities0976-28840976-28922021-04-01122596310.4103/injms.injms_158_20Clinical and Laboratory Profile of COVID-19 Patients Admitted at a Tertiary Care Center in New Delhi and Assessment of Factors Predicting Disease SeverityPiyush JainNitin SinhaM. K. Hari PrasadVaibhav PadoleBackground: This study was conducted in nonintensive care unit COVID-19 patients admitted in a tertiary care center, to assess the clinical profile and find surrogate markers to predict the severity of COVID-19 at the time of admission. Methodology: It is a cross-sectional observational study. Clinical and laboratory data were compiled of patients admitted in COVID wards in a tertiary care center. Patients were stratified clinically according to the severity of COVID pneumonia. The admission clinical and laboratory parameters were compared between the severe and nonsevere COVID patients. Results: The study included 63 patients of which 46 were males, with a mean age of 47 years. Patients were classified into mild (32%), moderate (19%), and severe (49%) categories according to national guidelines. Fever (81%), cough (67%), and dyspnea (67%) were the most commonly observed symptoms. In comparative analysis, mean C-reactive protein (CRP), serum ferritin, and neutrophil–lymphocyte ratio (NLR) were significantly higher in severe COVID-19 patients and the admission PaCO2 significantly lower compared to nonsevere patients. Conclusion: The study shows that raised NLR, CRP, serum ferritin, and low PaCO2 levels at the time of admission are important predictors of disease severity.https://journals.lww.com/10.4103/injms.injms_158_20clinical profilesars-cov-2severity biomarkers |
| spellingShingle | Piyush Jain Nitin Sinha M. K. Hari Prasad Vaibhav Padole Clinical and Laboratory Profile of COVID-19 Patients Admitted at a Tertiary Care Center in New Delhi and Assessment of Factors Predicting Disease Severity Indian Journal of Medical Specialities clinical profile sars-cov-2 severity biomarkers |
| title | Clinical and Laboratory Profile of COVID-19 Patients Admitted at a Tertiary Care Center in New Delhi and Assessment of Factors Predicting Disease Severity |
| title_full | Clinical and Laboratory Profile of COVID-19 Patients Admitted at a Tertiary Care Center in New Delhi and Assessment of Factors Predicting Disease Severity |
| title_fullStr | Clinical and Laboratory Profile of COVID-19 Patients Admitted at a Tertiary Care Center in New Delhi and Assessment of Factors Predicting Disease Severity |
| title_full_unstemmed | Clinical and Laboratory Profile of COVID-19 Patients Admitted at a Tertiary Care Center in New Delhi and Assessment of Factors Predicting Disease Severity |
| title_short | Clinical and Laboratory Profile of COVID-19 Patients Admitted at a Tertiary Care Center in New Delhi and Assessment of Factors Predicting Disease Severity |
| title_sort | clinical and laboratory profile of covid 19 patients admitted at a tertiary care center in new delhi and assessment of factors predicting disease severity |
| topic | clinical profile sars-cov-2 severity biomarkers |
| url | https://journals.lww.com/10.4103/injms.injms_158_20 |
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