Stress contingent changes in Hog1 pathway architecture and regulation in Candida albicans.

Stress contingent changes in Hog1 pathway architecture and regulation in Candida albicans.

The Hog1 stress-activated protein kinase (SAPK) is a key mediator of stress resistance and virulence in Candida albicans. Hog1 activation via phosphorylation of the canonical TGY motif is mediated by the Pbs2 MAPKK, which itself is activated by the Ssk2 MAPKKK. Although this three-tiered SAPK signal...

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Bibliographic Details
Main Authors: Alison M Day, Min Cao, Alessandra da Silva Dantas, Olga Ianieva, Carmen Herrero-de-Dios, Alistair J P Brown, Janet Quinn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-12-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012314
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