Biventricular longitudinal strain analysis using cardiovascular magnetic resonance feature-tracking: Prognostic value in Eisenmenger syndrome
ABSTRACT: Background: Evidence to support risk stratification in Eisenmenger syndrome (ES) is still very limited. We hypothesized that biventricular longitudinal strain analysis could have potential prognostic value in ES. Methods: We prospectively enrolled 57 consecutive ES patients with post-tric...
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Elsevier
2024-01-01
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| Series: | Journal of Cardiovascular Magnetic Resonance |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1097664724011438 |
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| author | Chao Gong Chen Chen Xuhan Liu Ke Wan Jiajun Guo Juan He Lidan Yin Bi Wen Shoufang Pu Yucheng Chen |
| author_facet | Chao Gong Chen Chen Xuhan Liu Ke Wan Jiajun Guo Juan He Lidan Yin Bi Wen Shoufang Pu Yucheng Chen |
| author_sort | Chao Gong |
| collection | DOAJ |
| description | ABSTRACT: Background: Evidence to support risk stratification in Eisenmenger syndrome (ES) is still very limited. We hypothesized that biventricular longitudinal strain analysis could have potential prognostic value in ES. Methods: We prospectively enrolled 57 consecutive ES patients with post-tricuspid shunt who underwent both cardiovascular magnetic resonance (CMR) and right heart catheterization between June 2013 and March 2022. Biventricular longitudinal strains were evaluated by CMR feature-tracking analysis. The composite endpoint included all-cause mortality and re-admission for heart failure or hemoptysis. Cox regression analysis, Kaplan–Meier curves, and C-index were employed to assess the relationship between biventricular longitudinal strain and prognosis. Results: During a median follow-up of 33 months (interquartile range: 12–50), 35.1% (20/57) patients reached the composite endpoint. Patients with composite endpoints had significantly lower absolute values of left ventricular global longitudinal strain (LV GLS) and right ventricular free wall longitudinal strain (RV FWLS) than patients without composite endpoints (p < .05). Multivariate Cox regression analysis demonstrated that LV GLS and RV FWLS were independent predictors for composite endpoints (hazard ratio [HR]: 1.37, 95% confidence interval [CI]: 1.08–1.75, p = 0.010 and HR: 1.19, 95% CI: 1.01–1.41, p = 0.042). Kaplan–Meier analysis indicated that patients with both lower absolute values of LV GLS and RV FWLS were more likely to be at an even higher risk of composite endpoints (p <0.001). Furthermore, the combined addition of LV GLS and RV FWLS provided incremental value for the prognostic model including clinical parameters and biventricular ejection fraction (C-index increased from 0.75 to 0.86, p = 0.004). Conclusion: Impaired biventricular longitudinal strains improved prognostic prediction of ES patients with post-tricuspid shunt. |
| format | Article |
| id | doaj-art-9c94169938eb4d649c0654b8aa2d6fe6 |
| institution | Kabale University |
| issn | 1097-6647 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Cardiovascular Magnetic Resonance |
| spelling | doaj-art-9c94169938eb4d649c0654b8aa2d6fe62024-12-16T05:34:56ZengElsevierJournal of Cardiovascular Magnetic Resonance1097-66472024-01-01262101116Biventricular longitudinal strain analysis using cardiovascular magnetic resonance feature-tracking: Prognostic value in Eisenmenger syndromeChao Gong0Chen Chen1Xuhan Liu2Ke Wan3Jiajun Guo4Juan He5Lidan Yin6Bi Wen7Shoufang Pu8Yucheng Chen9Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China; Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, PR ChinaDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR ChinaDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR ChinaDepartment of Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR ChinaDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR ChinaDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR ChinaDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR ChinaDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR ChinaDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR ChinaDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China; Corresponding author. Cardiology Division, West China Hospital, Sichuan University, Guoxue Xiang No. 37, Chengdu, Sichuan Province 610041, China.ABSTRACT: Background: Evidence to support risk stratification in Eisenmenger syndrome (ES) is still very limited. We hypothesized that biventricular longitudinal strain analysis could have potential prognostic value in ES. Methods: We prospectively enrolled 57 consecutive ES patients with post-tricuspid shunt who underwent both cardiovascular magnetic resonance (CMR) and right heart catheterization between June 2013 and March 2022. Biventricular longitudinal strains were evaluated by CMR feature-tracking analysis. The composite endpoint included all-cause mortality and re-admission for heart failure or hemoptysis. Cox regression analysis, Kaplan–Meier curves, and C-index were employed to assess the relationship between biventricular longitudinal strain and prognosis. Results: During a median follow-up of 33 months (interquartile range: 12–50), 35.1% (20/57) patients reached the composite endpoint. Patients with composite endpoints had significantly lower absolute values of left ventricular global longitudinal strain (LV GLS) and right ventricular free wall longitudinal strain (RV FWLS) than patients without composite endpoints (p < .05). Multivariate Cox regression analysis demonstrated that LV GLS and RV FWLS were independent predictors for composite endpoints (hazard ratio [HR]: 1.37, 95% confidence interval [CI]: 1.08–1.75, p = 0.010 and HR: 1.19, 95% CI: 1.01–1.41, p = 0.042). Kaplan–Meier analysis indicated that patients with both lower absolute values of LV GLS and RV FWLS were more likely to be at an even higher risk of composite endpoints (p <0.001). Furthermore, the combined addition of LV GLS and RV FWLS provided incremental value for the prognostic model including clinical parameters and biventricular ejection fraction (C-index increased from 0.75 to 0.86, p = 0.004). Conclusion: Impaired biventricular longitudinal strains improved prognostic prediction of ES patients with post-tricuspid shunt.http://www.sciencedirect.com/science/article/pii/S1097664724011438Cardiovascular magnetic resonanceEisenmenger syndromeFeature-trackingStrainPrognosis |
| spellingShingle | Chao Gong Chen Chen Xuhan Liu Ke Wan Jiajun Guo Juan He Lidan Yin Bi Wen Shoufang Pu Yucheng Chen Biventricular longitudinal strain analysis using cardiovascular magnetic resonance feature-tracking: Prognostic value in Eisenmenger syndrome Journal of Cardiovascular Magnetic Resonance Cardiovascular magnetic resonance Eisenmenger syndrome Feature-tracking Strain Prognosis |
| title | Biventricular longitudinal strain analysis using cardiovascular magnetic resonance feature-tracking: Prognostic value in Eisenmenger syndrome |
| title_full | Biventricular longitudinal strain analysis using cardiovascular magnetic resonance feature-tracking: Prognostic value in Eisenmenger syndrome |
| title_fullStr | Biventricular longitudinal strain analysis using cardiovascular magnetic resonance feature-tracking: Prognostic value in Eisenmenger syndrome |
| title_full_unstemmed | Biventricular longitudinal strain analysis using cardiovascular magnetic resonance feature-tracking: Prognostic value in Eisenmenger syndrome |
| title_short | Biventricular longitudinal strain analysis using cardiovascular magnetic resonance feature-tracking: Prognostic value in Eisenmenger syndrome |
| title_sort | biventricular longitudinal strain analysis using cardiovascular magnetic resonance feature tracking prognostic value in eisenmenger syndrome |
| topic | Cardiovascular magnetic resonance Eisenmenger syndrome Feature-tracking Strain Prognosis |
| url | http://www.sciencedirect.com/science/article/pii/S1097664724011438 |
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