Formulation and Evaluation of Facial Serum Containing Sacha Inchi Oil (<i>Plukenetia volubilis</i> L.) from Indonesia as an Anti-Aging: Stability, In Vitro, and Skin Irritation Assessments
Reactive oxygen species (ROS), commonly recognized as free radicals, significantly contribute to skin damage by disrupting defense and repair mechanisms, thereby accelerating the aging process. An effective strategy to prevent and alleviate skin aging involves the application of topical formulations...
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MDPI AG
2024-12-01
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| Series: | Cosmetics |
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| Online Access: | https://www.mdpi.com/2079-9284/11/6/226 |
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| author | Ira Maya Sriwidodo Sriwidodo Soraya Ratnawulan Mita Cahya Khairani Kusumawulan Norisca Aliza Putriana Eri Amalia Rizqa Nurul Aulia Hadiyan Nur Sofyan Fauzan Dzulfannazhir Moh Hamdan Nugraha |
| author_facet | Ira Maya Sriwidodo Sriwidodo Soraya Ratnawulan Mita Cahya Khairani Kusumawulan Norisca Aliza Putriana Eri Amalia Rizqa Nurul Aulia Hadiyan Nur Sofyan Fauzan Dzulfannazhir Moh Hamdan Nugraha |
| author_sort | Ira Maya |
| collection | DOAJ |
| description | Reactive oxygen species (ROS), commonly recognized as free radicals, significantly contribute to skin damage by disrupting defense and repair mechanisms, thereby accelerating the aging process. An effective strategy to prevent and alleviate skin aging involves the application of topical formulations enriched with powerful antioxidant compounds. Sacha inchi oil (<i>Plukenetia volubilis</i> L.) has been reported to possess significant antioxidant activity, while its oil contains a high content of omega-3 fatty acids, offering potential anti-aging benefits. This study aims to evaluate the stability, in vitro anti-aging activity, and skin irritation assessments of a facial serum containing Sacha inchi oil (SIO) formulated as a topical anti-aging agent. The stability of the serum was assessed by analyzing its organoleptic properties, homogeneity, viscosity, spreadability, pH, microbial contamination, and heavy metal content over a three-month period under controlled climatic conditions. The in vitro anti-aging activity was evaluated through enzyme inhibition assays for neutrophil elastase and collagenase, while skin irritation was assessed via human patch testing. The results indicated that the SIO facial serum exhibits excellent stability, significant anti-aging activity, and is safe for topical application, with no irritant effects observed during skin irritation assessments. |
| format | Article |
| id | doaj-art-9c891c3511a84f2388c98cfaf09b33be |
| institution | Kabale University |
| issn | 2079-9284 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cosmetics |
| spelling | doaj-art-9c891c3511a84f2388c98cfaf09b33be2024-12-27T14:19:25ZengMDPI AGCosmetics2079-92842024-12-0111622610.3390/cosmetics11060226Formulation and Evaluation of Facial Serum Containing Sacha Inchi Oil (<i>Plukenetia volubilis</i> L.) from Indonesia as an Anti-Aging: Stability, In Vitro, and Skin Irritation AssessmentsIra Maya0Sriwidodo Sriwidodo1Soraya Ratnawulan Mita2Cahya Khairani Kusumawulan3Norisca Aliza Putriana4Eri Amalia5Rizqa Nurul Aulia6Hadiyan Nur Sofyan7Fauzan Dzulfannazhir8Moh Hamdan Nugraha9Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, IndonesiaDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, IndonesiaDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, IndonesiaPT. Lunaray Cahya Abadi, Cosmetics Industry, Bandung 40217, IndonesiaDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, IndonesiaDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, IndonesiaDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, IndonesiaQuilla Indonesia, Natural Raw Materials Industry, Bandung 40286, IndonesiaQuilla Indonesia, Natural Raw Materials Industry, Bandung 40286, IndonesiaQuilla Indonesia, Natural Raw Materials Industry, Bandung 40286, IndonesiaReactive oxygen species (ROS), commonly recognized as free radicals, significantly contribute to skin damage by disrupting defense and repair mechanisms, thereby accelerating the aging process. An effective strategy to prevent and alleviate skin aging involves the application of topical formulations enriched with powerful antioxidant compounds. Sacha inchi oil (<i>Plukenetia volubilis</i> L.) has been reported to possess significant antioxidant activity, while its oil contains a high content of omega-3 fatty acids, offering potential anti-aging benefits. This study aims to evaluate the stability, in vitro anti-aging activity, and skin irritation assessments of a facial serum containing Sacha inchi oil (SIO) formulated as a topical anti-aging agent. The stability of the serum was assessed by analyzing its organoleptic properties, homogeneity, viscosity, spreadability, pH, microbial contamination, and heavy metal content over a three-month period under controlled climatic conditions. The in vitro anti-aging activity was evaluated through enzyme inhibition assays for neutrophil elastase and collagenase, while skin irritation was assessed via human patch testing. The results indicated that the SIO facial serum exhibits excellent stability, significant anti-aging activity, and is safe for topical application, with no irritant effects observed during skin irritation assessments.https://www.mdpi.com/2079-9284/11/6/226Sacha inchi oilfacial serumanti-agingstabilityirritation testing |
| spellingShingle | Ira Maya Sriwidodo Sriwidodo Soraya Ratnawulan Mita Cahya Khairani Kusumawulan Norisca Aliza Putriana Eri Amalia Rizqa Nurul Aulia Hadiyan Nur Sofyan Fauzan Dzulfannazhir Moh Hamdan Nugraha Formulation and Evaluation of Facial Serum Containing Sacha Inchi Oil (<i>Plukenetia volubilis</i> L.) from Indonesia as an Anti-Aging: Stability, In Vitro, and Skin Irritation Assessments Cosmetics Sacha inchi oil facial serum anti-aging stability irritation testing |
| title | Formulation and Evaluation of Facial Serum Containing Sacha Inchi Oil (<i>Plukenetia volubilis</i> L.) from Indonesia as an Anti-Aging: Stability, In Vitro, and Skin Irritation Assessments |
| title_full | Formulation and Evaluation of Facial Serum Containing Sacha Inchi Oil (<i>Plukenetia volubilis</i> L.) from Indonesia as an Anti-Aging: Stability, In Vitro, and Skin Irritation Assessments |
| title_fullStr | Formulation and Evaluation of Facial Serum Containing Sacha Inchi Oil (<i>Plukenetia volubilis</i> L.) from Indonesia as an Anti-Aging: Stability, In Vitro, and Skin Irritation Assessments |
| title_full_unstemmed | Formulation and Evaluation of Facial Serum Containing Sacha Inchi Oil (<i>Plukenetia volubilis</i> L.) from Indonesia as an Anti-Aging: Stability, In Vitro, and Skin Irritation Assessments |
| title_short | Formulation and Evaluation of Facial Serum Containing Sacha Inchi Oil (<i>Plukenetia volubilis</i> L.) from Indonesia as an Anti-Aging: Stability, In Vitro, and Skin Irritation Assessments |
| title_sort | formulation and evaluation of facial serum containing sacha inchi oil i plukenetia volubilis i l from indonesia as an anti aging stability in vitro and skin irritation assessments |
| topic | Sacha inchi oil facial serum anti-aging stability irritation testing |
| url | https://www.mdpi.com/2079-9284/11/6/226 |
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