Effects of rotigotine on sleep in Parkinson’s disease patients: a Parkinson’s KinetiGraph study
IntroductionRecent studies suggest that the dopamine agonist (DA) rotigotine improves sleep among Parkinson disease (PD) patients. Parkinson’s KinetiGraph (PKG) offers a home-based alternative for evaluating sleep. We investigated the effect of rotigotine on sleep in PD patients with PKG and questio...
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Frontiers Media S.A.
2025-05-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1591537/full |
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| author | Sotirios Grigoriou Sotirios Grigoriou Carin Janz Carin Janz Malcolm Horne Filip Bergquist Filip Bergquist Nil Dizdar Per Odin Per Odin |
| author_facet | Sotirios Grigoriou Sotirios Grigoriou Carin Janz Carin Janz Malcolm Horne Filip Bergquist Filip Bergquist Nil Dizdar Per Odin Per Odin |
| author_sort | Sotirios Grigoriou |
| collection | DOAJ |
| description | IntroductionRecent studies suggest that the dopamine agonist (DA) rotigotine improves sleep among Parkinson disease (PD) patients. Parkinson’s KinetiGraph (PKG) offers a home-based alternative for evaluating sleep. We investigated the effect of rotigotine on sleep in PD patients with PKG and questionnaires. Secondarily, the effects of rotigotine on daytime sleepiness, motor symptoms, quality of life and correlations between PKG variables and rating scale results were investigated.MethodThirty-two PD patients with sleep disturbances (Clinical Global Impression-Severity (CGI-S) ≥ 3) were included in this observational study. Before start of treatment and during stable dose with rotigotine patients were assessed with Parkinson’s disease sleep scale 2 (PDSS-2), Epworth Sleepiness Scale (ESS), Parkinson’s disease quality of life questionnaire (PDQ-8), European Quality of life five dimensions (EQ-5D-5L) questionnaires and PKG recordings (24 h/day for 6 days). Clinicians evaluated sleep using CGI scales, and PD severity using Clinical Impression of Severity Index for Parkinson’s Disease (CISI-PD).ResultsRotigotine did not significantly improve total PDSS-2 or PKG nighttime scores in the entire group, but PDSS-2 improved among patients with PDSS-2 ≥ 18 at baseline and for DA-naïve patients (p = 0.009 and p = 0.013). Treatment improved percent time tremor (PTT; p < 0.001), percent time immobile during daytime (PTID; p < 0.001), CISI-PD (p < 0.001), PDQ-8 (p = 0.014), and EQ-5D-5L (p = 0.002). No significant correlations were found between PTID and ESS-total (ρ = −0.046, p = 0.718) or between combined sleep score (CSS) and PDSS-2 total (ρ = −0.065, p = 0.612).ConclusionRotigotine improved sleep in patients with a baseline PDSS-2 ≥ 18 and in DA-naïve patients, but not in the whole study group. Additionally, rotigotine seemed to improve motor function and quality of life. PTID improved with treatment. Whether the improved PTID reflects a positive impact on daytime sleepiness or just improved mobility and to what extent PKG nighttime scores accurately represent sleep variables remains to be investigated in further studies. |
| format | Article |
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| institution | Kabale University |
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| publishDate | 2025-05-01 |
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| spelling | doaj-art-9c7b52c15a734f0fa3ece75a6fdea2af2025-08-20T03:47:58ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-05-011610.3389/fneur.2025.15915371591537Effects of rotigotine on sleep in Parkinson’s disease patients: a Parkinson’s KinetiGraph studySotirios Grigoriou0Sotirios Grigoriou1Carin Janz2Carin Janz3Malcolm Horne4Filip Bergquist5Filip Bergquist6Nil Dizdar7Per Odin8Per Odin9Division of Neurology, Department of Clinical Sciences Lund, Lund University, Lund, SwedenDepartment of Neurology, Rehabilitation Medicine, Memory and Geriatrics, Skane University Hospital, Lund, SwedenDivision of Neurology, Department of Clinical Sciences Lund, Lund University, Lund, SwedenDepartment of Neurology, Rehabilitation Medicine, Memory and Geriatrics, Skane University Hospital, Lund, SwedenDepartment of Medicine, St Vincent’s Hospital, University of Melbourne, Melbourne, VIC, AustraliaDivision of Neurology, Sahlgrenska University Hospital, Gothenburg, SwedenDepartment of Pharmacology, University of Gothenburg, Gothenburg, SwedenDepartment of Biomedical and Clinical Sciences, Linkoping University, Linköping, SwedenDivision of Neurology, Department of Clinical Sciences Lund, Lund University, Lund, SwedenDepartment of Neurology, Rehabilitation Medicine, Memory and Geriatrics, Skane University Hospital, Lund, SwedenIntroductionRecent studies suggest that the dopamine agonist (DA) rotigotine improves sleep among Parkinson disease (PD) patients. Parkinson’s KinetiGraph (PKG) offers a home-based alternative for evaluating sleep. We investigated the effect of rotigotine on sleep in PD patients with PKG and questionnaires. Secondarily, the effects of rotigotine on daytime sleepiness, motor symptoms, quality of life and correlations between PKG variables and rating scale results were investigated.MethodThirty-two PD patients with sleep disturbances (Clinical Global Impression-Severity (CGI-S) ≥ 3) were included in this observational study. Before start of treatment and during stable dose with rotigotine patients were assessed with Parkinson’s disease sleep scale 2 (PDSS-2), Epworth Sleepiness Scale (ESS), Parkinson’s disease quality of life questionnaire (PDQ-8), European Quality of life five dimensions (EQ-5D-5L) questionnaires and PKG recordings (24 h/day for 6 days). Clinicians evaluated sleep using CGI scales, and PD severity using Clinical Impression of Severity Index for Parkinson’s Disease (CISI-PD).ResultsRotigotine did not significantly improve total PDSS-2 or PKG nighttime scores in the entire group, but PDSS-2 improved among patients with PDSS-2 ≥ 18 at baseline and for DA-naïve patients (p = 0.009 and p = 0.013). Treatment improved percent time tremor (PTT; p < 0.001), percent time immobile during daytime (PTID; p < 0.001), CISI-PD (p < 0.001), PDQ-8 (p = 0.014), and EQ-5D-5L (p = 0.002). No significant correlations were found between PTID and ESS-total (ρ = −0.046, p = 0.718) or between combined sleep score (CSS) and PDSS-2 total (ρ = −0.065, p = 0.612).ConclusionRotigotine improved sleep in patients with a baseline PDSS-2 ≥ 18 and in DA-naïve patients, but not in the whole study group. Additionally, rotigotine seemed to improve motor function and quality of life. PTID improved with treatment. Whether the improved PTID reflects a positive impact on daytime sleepiness or just improved mobility and to what extent PKG nighttime scores accurately represent sleep variables remains to be investigated in further studies.https://www.frontiersin.org/articles/10.3389/fneur.2025.1591537/fullParkinson’s diseaseParkinson’s KinetiGraphrotigotinesleep disturbancesParkinson disease sleep scale-2sleep quality |
| spellingShingle | Sotirios Grigoriou Sotirios Grigoriou Carin Janz Carin Janz Malcolm Horne Filip Bergquist Filip Bergquist Nil Dizdar Per Odin Per Odin Effects of rotigotine on sleep in Parkinson’s disease patients: a Parkinson’s KinetiGraph study Frontiers in Neurology Parkinson’s disease Parkinson’s KinetiGraph rotigotine sleep disturbances Parkinson disease sleep scale-2 sleep quality |
| title | Effects of rotigotine on sleep in Parkinson’s disease patients: a Parkinson’s KinetiGraph study |
| title_full | Effects of rotigotine on sleep in Parkinson’s disease patients: a Parkinson’s KinetiGraph study |
| title_fullStr | Effects of rotigotine on sleep in Parkinson’s disease patients: a Parkinson’s KinetiGraph study |
| title_full_unstemmed | Effects of rotigotine on sleep in Parkinson’s disease patients: a Parkinson’s KinetiGraph study |
| title_short | Effects of rotigotine on sleep in Parkinson’s disease patients: a Parkinson’s KinetiGraph study |
| title_sort | effects of rotigotine on sleep in parkinson s disease patients a parkinson s kinetigraph study |
| topic | Parkinson’s disease Parkinson’s KinetiGraph rotigotine sleep disturbances Parkinson disease sleep scale-2 sleep quality |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1591537/full |
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