Angiopoietin-like protein 4 dysregulation in kidney diseases: a promising biomarker and therapeutic target
The global burden of renal diseases is increasingly severe, underscoring the need for in-depth exploration of the molecular mechanisms underlying renal disease progression and the development of potential novel biomarkers or therapeutic targets. Angiopoietin-like protein 4 (ANGPTL4) is a multifuncti...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1475198/full |
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| author | Yan Li Yan Li Yan Li Yuxin Zhang Yuxin Zhang Yuxin Zhang Mengxia Cao Mengxia Cao Mengxia Cao Tingting Yuan Tingting Yuan Tingting Yuan Santao Ou Santao Ou Santao Ou |
| author_facet | Yan Li Yan Li Yan Li Yuxin Zhang Yuxin Zhang Yuxin Zhang Mengxia Cao Mengxia Cao Mengxia Cao Tingting Yuan Tingting Yuan Tingting Yuan Santao Ou Santao Ou Santao Ou |
| author_sort | Yan Li |
| collection | DOAJ |
| description | The global burden of renal diseases is increasingly severe, underscoring the need for in-depth exploration of the molecular mechanisms underlying renal disease progression and the development of potential novel biomarkers or therapeutic targets. Angiopoietin-like protein 4 (ANGPTL4) is a multifunctional cytokine involved in the regulation of key biological processes, such as glucose and lipid metabolism, inflammation, vascular permeability, and angiogenesis, all of which play crucial roles in the pathogenesis of kidney diseases. Over the past 2 decades, ANGPTL4 has been regarded as playing a pivotal role in the progression of various kidney diseases, prompting significant interest from the scientific community regarding its potential clinical utility in renal disorders. This review synthesizes the available literature, provides a concise overview of the molecular biological effects of ANGPTL4, and highlights its relationship with multiple renal diseases and recent research advancements. These findings underscore the important gaps that warrant further investigation to develop novel targets for the prediction or treatment of various renal diseases. |
| format | Article |
| id | doaj-art-9c6f0ac53f9645dfac32cfebebf95e6f |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-9c6f0ac53f9645dfac32cfebebf95e6f2025-01-07T06:50:32ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011510.3389/fphar.2024.14751981475198Angiopoietin-like protein 4 dysregulation in kidney diseases: a promising biomarker and therapeutic targetYan Li0Yan Li1Yan Li2Yuxin Zhang3Yuxin Zhang4Yuxin Zhang5Mengxia Cao6Mengxia Cao7Mengxia Cao8Tingting Yuan9Tingting Yuan10Tingting Yuan11Santao Ou12Santao Ou13Santao Ou14Department of Nephrology, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaSichuan Clinical Research Center for Nephrology, Luzhou, ChinaMetabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, ChinaDepartment of Nephrology, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaSichuan Clinical Research Center for Nephrology, Luzhou, ChinaMetabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, ChinaDepartment of Nephrology, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaSichuan Clinical Research Center for Nephrology, Luzhou, ChinaMetabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, ChinaDepartment of Nephrology, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaSichuan Clinical Research Center for Nephrology, Luzhou, ChinaMetabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, ChinaDepartment of Nephrology, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaSichuan Clinical Research Center for Nephrology, Luzhou, ChinaMetabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, ChinaThe global burden of renal diseases is increasingly severe, underscoring the need for in-depth exploration of the molecular mechanisms underlying renal disease progression and the development of potential novel biomarkers or therapeutic targets. Angiopoietin-like protein 4 (ANGPTL4) is a multifunctional cytokine involved in the regulation of key biological processes, such as glucose and lipid metabolism, inflammation, vascular permeability, and angiogenesis, all of which play crucial roles in the pathogenesis of kidney diseases. Over the past 2 decades, ANGPTL4 has been regarded as playing a pivotal role in the progression of various kidney diseases, prompting significant interest from the scientific community regarding its potential clinical utility in renal disorders. This review synthesizes the available literature, provides a concise overview of the molecular biological effects of ANGPTL4, and highlights its relationship with multiple renal diseases and recent research advancements. These findings underscore the important gaps that warrant further investigation to develop novel targets for the prediction or treatment of various renal diseases.https://www.frontiersin.org/articles/10.3389/fphar.2024.1475198/fullangiopoietin-like protein 4renal diseasesbiomarkertherapeuticsmechanisminflammation |
| spellingShingle | Yan Li Yan Li Yan Li Yuxin Zhang Yuxin Zhang Yuxin Zhang Mengxia Cao Mengxia Cao Mengxia Cao Tingting Yuan Tingting Yuan Tingting Yuan Santao Ou Santao Ou Santao Ou Angiopoietin-like protein 4 dysregulation in kidney diseases: a promising biomarker and therapeutic target Frontiers in Pharmacology angiopoietin-like protein 4 renal diseases biomarker therapeutics mechanism inflammation |
| title | Angiopoietin-like protein 4 dysregulation in kidney diseases: a promising biomarker and therapeutic target |
| title_full | Angiopoietin-like protein 4 dysregulation in kidney diseases: a promising biomarker and therapeutic target |
| title_fullStr | Angiopoietin-like protein 4 dysregulation in kidney diseases: a promising biomarker and therapeutic target |
| title_full_unstemmed | Angiopoietin-like protein 4 dysregulation in kidney diseases: a promising biomarker and therapeutic target |
| title_short | Angiopoietin-like protein 4 dysregulation in kidney diseases: a promising biomarker and therapeutic target |
| title_sort | angiopoietin like protein 4 dysregulation in kidney diseases a promising biomarker and therapeutic target |
| topic | angiopoietin-like protein 4 renal diseases biomarker therapeutics mechanism inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1475198/full |
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