Case Report: Management of a case of multidrug-resistant Klebsiella pneumoniae infection in a second-kidney transplant patient
This case report on recurrent urinary tract infections (UTIs) caused by multidrug-resistant (MDR) Klebsiella pneumoniae in a post-renal transplant patient underscores the significant clinical challenge of managing MDR infections in immunocompromised individuals, particularly in the context of renal...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Transplantation |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/frtra.2024.1494016/full |
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| author | Supreeta R. Shettar Mahadevaiah Neelambike Sumana Manjunath S. Shetty Yogeesh D. Maheshwarappa Reddy G. Raghukanth Asha Srinivasan Dharan P. Vamshi Gautam Kalyatanda Swamy G. S. Veerabhadra Shylaja Eshwarappa Chinchana |
| author_facet | Supreeta R. Shettar Mahadevaiah Neelambike Sumana Manjunath S. Shetty Yogeesh D. Maheshwarappa Reddy G. Raghukanth Asha Srinivasan Dharan P. Vamshi Gautam Kalyatanda Swamy G. S. Veerabhadra Shylaja Eshwarappa Chinchana |
| author_sort | Supreeta R. Shettar |
| collection | DOAJ |
| description | This case report on recurrent urinary tract infections (UTIs) caused by multidrug-resistant (MDR) Klebsiella pneumoniae in a post-renal transplant patient underscores the significant clinical challenge of managing MDR infections in immunocompromised individuals, particularly in the context of renal transplantation. The patient was treated with an extended infusion of meropenem, which offers prolonged drug exposure and enhances bactericidal activity against MDR pathogens. This approach is critical in overcoming the resistance mechanisms inherent to Klebsiella pneumoniae, thereby improving the likelihood of therapeutic success. The findings presented here highlight the potential efficacy of extended meropenem infusion in treating MDR infections, providing a valuable therapeutic option for clinicians facing similar cases. This report contributes to the growing evidence supporting advanced antibiotic administration techniques in managing complicated urinary tract infections in transplant in resource limited countries. |
| format | Article |
| id | doaj-art-9c6eda1ac6e44f5581549f4192b7bae8 |
| institution | Kabale University |
| issn | 2813-2440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Transplantation |
| spelling | doaj-art-9c6eda1ac6e44f5581549f4192b7bae82025-01-17T06:51:05ZengFrontiers Media S.A.Frontiers in Transplantation2813-24402025-01-01310.3389/frtra.2024.14940161494016Case Report: Management of a case of multidrug-resistant Klebsiella pneumoniae infection in a second-kidney transplant patientSupreeta R. Shettar0Mahadevaiah Neelambike Sumana1Manjunath S. Shetty2Yogeesh D. Maheshwarappa3Reddy G. Raghukanth4Asha Srinivasan5Dharan P. Vamshi6Gautam Kalyatanda7Swamy G. S. Veerabhadra8Shylaja Eshwarappa Chinchana9JSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysuru, IndiaJSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysuru, IndiaJSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysuru, IndiaJSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysuru, IndiaJSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysuru, IndiaDepartment of Nanoscience and Technology, School of Life Sciences, JSS Academy of Higher Education and Research, Mysuru, IndiaJSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysuru, IndiaDivision of Infectious Disease and Global Medicine, University of Florida, Gainesville, FL, United StatesJSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysuru, IndiaJSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysuru, IndiaThis case report on recurrent urinary tract infections (UTIs) caused by multidrug-resistant (MDR) Klebsiella pneumoniae in a post-renal transplant patient underscores the significant clinical challenge of managing MDR infections in immunocompromised individuals, particularly in the context of renal transplantation. The patient was treated with an extended infusion of meropenem, which offers prolonged drug exposure and enhances bactericidal activity against MDR pathogens. This approach is critical in overcoming the resistance mechanisms inherent to Klebsiella pneumoniae, thereby improving the likelihood of therapeutic success. The findings presented here highlight the potential efficacy of extended meropenem infusion in treating MDR infections, providing a valuable therapeutic option for clinicians facing similar cases. This report contributes to the growing evidence supporting advanced antibiotic administration techniques in managing complicated urinary tract infections in transplant in resource limited countries.https://www.frontiersin.org/articles/10.3389/frtra.2024.1494016/fullmultidrug-resistant organismsmultidrug-resistant Klebsiella pneumoniaeurinary tract infectionkidney transplantationimmunocompromised conditionextended β-lactam infusion |
| spellingShingle | Supreeta R. Shettar Mahadevaiah Neelambike Sumana Manjunath S. Shetty Yogeesh D. Maheshwarappa Reddy G. Raghukanth Asha Srinivasan Dharan P. Vamshi Gautam Kalyatanda Swamy G. S. Veerabhadra Shylaja Eshwarappa Chinchana Case Report: Management of a case of multidrug-resistant Klebsiella pneumoniae infection in a second-kidney transplant patient Frontiers in Transplantation multidrug-resistant organisms multidrug-resistant Klebsiella pneumoniae urinary tract infection kidney transplantation immunocompromised condition extended β-lactam infusion |
| title | Case Report: Management of a case of multidrug-resistant Klebsiella pneumoniae infection in a second-kidney transplant patient |
| title_full | Case Report: Management of a case of multidrug-resistant Klebsiella pneumoniae infection in a second-kidney transplant patient |
| title_fullStr | Case Report: Management of a case of multidrug-resistant Klebsiella pneumoniae infection in a second-kidney transplant patient |
| title_full_unstemmed | Case Report: Management of a case of multidrug-resistant Klebsiella pneumoniae infection in a second-kidney transplant patient |
| title_short | Case Report: Management of a case of multidrug-resistant Klebsiella pneumoniae infection in a second-kidney transplant patient |
| title_sort | case report management of a case of multidrug resistant klebsiella pneumoniae infection in a second kidney transplant patient |
| topic | multidrug-resistant organisms multidrug-resistant Klebsiella pneumoniae urinary tract infection kidney transplantation immunocompromised condition extended β-lactam infusion |
| url | https://www.frontiersin.org/articles/10.3389/frtra.2024.1494016/full |
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