Exploring the potential of Fargesin from Chrysanthemum indicum for chronic migraine: in-silico and pharmacokinetic study
Introduction Chronic migraine is recognized by the WHO as one of the most debilitating chronic conditions. It is primarily caused by central sensitization of the trigeminal nucleus caudalis. Key biomarkers associated with migraine include NFkB, IL-1β, CGRP, and iNOS. While CGRP antagonists have prov...
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Taylor & Francis Group
2024-12-01
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| Series: | Future Science OA |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/20565623.2024.2428119 |
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| author | Rapuru Rushendran Vellapandian Chitra |
| author_facet | Rapuru Rushendran Vellapandian Chitra |
| author_sort | Rapuru Rushendran |
| collection | DOAJ |
| description | Introduction Chronic migraine is recognized by the WHO as one of the most debilitating chronic conditions. It is primarily caused by central sensitization of the trigeminal nucleus caudalis. Key biomarkers associated with migraine include NFkB, IL-1β, CGRP, and iNOS. While CGRP antagonists have proven effective in treating migraines, Chrysanthemum indicum L., a traditional herbal remedy, has not been established as a treatment.Methods To address this, we investigated whether Fargesin, a lignan found in CI, could potentially reduce migraines by targeting these biomarkers. We conducted pharmacokinetic, toxicological, and in-silico studies. Molecular docking studies revealed a strong interaction between Fargesin and CGRP/iNOS.Results The pharmacokinetic analysis indicated robust intestinal absorption and effective penetration of the blood-brain barrier. In-silico toxicity assessments showed favorable results. Promising interactions with drug targets were observed in bioactivity tests.Conclusion Fargesin from Chrysanthemum indicum may hold potential as a therapeutic agent for migraines. |
| format | Article |
| id | doaj-art-9c27a6b493e547928c4f9abcae170ba0 |
| institution | Kabale University |
| issn | 2056-5623 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Future Science OA |
| spelling | doaj-art-9c27a6b493e547928c4f9abcae170ba02024-11-19T13:17:06ZengTaylor & Francis GroupFuture Science OA2056-56232024-12-0110110.1080/20565623.2024.2428119Exploring the potential of Fargesin from Chrysanthemum indicum for chronic migraine: in-silico and pharmacokinetic studyRapuru Rushendran0Vellapandian Chitra1Department of Pharmacology, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, IndiaDepartment of Pharmacology, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, IndiaIntroduction Chronic migraine is recognized by the WHO as one of the most debilitating chronic conditions. It is primarily caused by central sensitization of the trigeminal nucleus caudalis. Key biomarkers associated with migraine include NFkB, IL-1β, CGRP, and iNOS. While CGRP antagonists have proven effective in treating migraines, Chrysanthemum indicum L., a traditional herbal remedy, has not been established as a treatment.Methods To address this, we investigated whether Fargesin, a lignan found in CI, could potentially reduce migraines by targeting these biomarkers. We conducted pharmacokinetic, toxicological, and in-silico studies. Molecular docking studies revealed a strong interaction between Fargesin and CGRP/iNOS.Results The pharmacokinetic analysis indicated robust intestinal absorption and effective penetration of the blood-brain barrier. In-silico toxicity assessments showed favorable results. Promising interactions with drug targets were observed in bioactivity tests.Conclusion Fargesin from Chrysanthemum indicum may hold potential as a therapeutic agent for migraines.https://www.tandfonline.com/doi/10.1080/20565623.2024.2428119Chronic migrainedocking, toxicitypharmacokineticFargesinNeolignanChrysanthemum indicum |
| spellingShingle | Rapuru Rushendran Vellapandian Chitra Exploring the potential of Fargesin from Chrysanthemum indicum for chronic migraine: in-silico and pharmacokinetic study Future Science OA Chronic migraine docking, toxicity pharmacokinetic Fargesin Neolignan Chrysanthemum indicum |
| title | Exploring the potential of Fargesin from Chrysanthemum indicum for chronic migraine: in-silico and pharmacokinetic study |
| title_full | Exploring the potential of Fargesin from Chrysanthemum indicum for chronic migraine: in-silico and pharmacokinetic study |
| title_fullStr | Exploring the potential of Fargesin from Chrysanthemum indicum for chronic migraine: in-silico and pharmacokinetic study |
| title_full_unstemmed | Exploring the potential of Fargesin from Chrysanthemum indicum for chronic migraine: in-silico and pharmacokinetic study |
| title_short | Exploring the potential of Fargesin from Chrysanthemum indicum for chronic migraine: in-silico and pharmacokinetic study |
| title_sort | exploring the potential of fargesin from chrysanthemum indicum for chronic migraine in silico and pharmacokinetic study |
| topic | Chronic migraine docking, toxicity pharmacokinetic Fargesin Neolignan Chrysanthemum indicum |
| url | https://www.tandfonline.com/doi/10.1080/20565623.2024.2428119 |
| work_keys_str_mv | AT rapururushendran exploringthepotentialoffargesinfromchrysanthemumindicumforchronicmigraineinsilicoandpharmacokineticstudy AT vellapandianchitra exploringthepotentialoffargesinfromchrysanthemumindicumforchronicmigraineinsilicoandpharmacokineticstudy |