Immune-related adverse events with renal colic as the main manifestation: a case report of sintilimab-induced ureteritis/cystitis treated by ureteral stent and review of the literature
Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of systemic cancer therapy. During disinhibiting the antitumor responses of immune system, ICIs may also cause unique immune-related adverse events (irAEs) which could affect any organ. Here, we report a rare case of sintilimab-in...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1501415/full |
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| author | Jiaxiang Ji Jiaxiang Ji Chin-Hui Lai Chin-Hui Lai Xiaowei Zhang Xiaowei Zhang Hao Hu Hao Hu |
| author_facet | Jiaxiang Ji Jiaxiang Ji Chin-Hui Lai Chin-Hui Lai Xiaowei Zhang Xiaowei Zhang Hao Hu Hao Hu |
| author_sort | Jiaxiang Ji |
| collection | DOAJ |
| description | Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of systemic cancer therapy. During disinhibiting the antitumor responses of immune system, ICIs may also cause unique immune-related adverse events (irAEs) which could affect any organ. Here, we report a rare case of sintilimab-induced ureteritis/cystitis in a 55-year-old male undergoing neoadjuvant chemo-immunotherapy for gastric cancer. The patient presented with severe renal colic, hematuria, and hydronephrosis. Antibiotic antispasmodic and nonsteroidal anti-inflammatory drug treatment failed to alleviate symptoms. The application of corticosteroid was negated for recent extirpative surgery under plan. Bilateral ureteral stenting effectively resolved the pain and improved renal function. The patient later successfully underwent laparoscopic radical gastrectomy with significant tumor regression in postoperative pathology. This case highlights ureteral stenting as a potential corticosteroid-free treatment option for ICI-induced ureteritis/cystitis. |
| format | Article |
| id | doaj-art-9c08f6078c0a4a75abae8fdb9a70a186 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-9c08f6078c0a4a75abae8fdb9a70a1862024-12-23T06:38:57ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-12-011510.3389/fimmu.2024.15014151501415Immune-related adverse events with renal colic as the main manifestation: a case report of sintilimab-induced ureteritis/cystitis treated by ureteral stent and review of the literatureJiaxiang Ji0Jiaxiang Ji1Chin-Hui Lai2Chin-Hui Lai3Xiaowei Zhang4Xiaowei Zhang5Hao Hu6Hao Hu7Department of Urology, Peking University People’s Hospital, Beijing, ChinaThe institute of applied lithotripsy technology, Peking University, Beijing, ChinaDepartment of Urology, Peking University People’s Hospital, Beijing, ChinaThe institute of applied lithotripsy technology, Peking University, Beijing, ChinaDepartment of Urology, Peking University People’s Hospital, Beijing, ChinaThe institute of applied lithotripsy technology, Peking University, Beijing, ChinaDepartment of Urology, Peking University People’s Hospital, Beijing, ChinaThe institute of applied lithotripsy technology, Peking University, Beijing, ChinaImmune checkpoint inhibitors (ICIs) have revolutionized the treatment of systemic cancer therapy. During disinhibiting the antitumor responses of immune system, ICIs may also cause unique immune-related adverse events (irAEs) which could affect any organ. Here, we report a rare case of sintilimab-induced ureteritis/cystitis in a 55-year-old male undergoing neoadjuvant chemo-immunotherapy for gastric cancer. The patient presented with severe renal colic, hematuria, and hydronephrosis. Antibiotic antispasmodic and nonsteroidal anti-inflammatory drug treatment failed to alleviate symptoms. The application of corticosteroid was negated for recent extirpative surgery under plan. Bilateral ureteral stenting effectively resolved the pain and improved renal function. The patient later successfully underwent laparoscopic radical gastrectomy with significant tumor regression in postoperative pathology. This case highlights ureteral stenting as a potential corticosteroid-free treatment option for ICI-induced ureteritis/cystitis.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1501415/fullimmune checkpoint inhibitors (ICIs)immune-related adverse events (irAEs)sintilimabureteritis/cystitisureteral stent |
| spellingShingle | Jiaxiang Ji Jiaxiang Ji Chin-Hui Lai Chin-Hui Lai Xiaowei Zhang Xiaowei Zhang Hao Hu Hao Hu Immune-related adverse events with renal colic as the main manifestation: a case report of sintilimab-induced ureteritis/cystitis treated by ureteral stent and review of the literature Frontiers in Immunology immune checkpoint inhibitors (ICIs) immune-related adverse events (irAEs) sintilimab ureteritis/cystitis ureteral stent |
| title | Immune-related adverse events with renal colic as the main manifestation: a case report of sintilimab-induced ureteritis/cystitis treated by ureteral stent and review of the literature |
| title_full | Immune-related adverse events with renal colic as the main manifestation: a case report of sintilimab-induced ureteritis/cystitis treated by ureteral stent and review of the literature |
| title_fullStr | Immune-related adverse events with renal colic as the main manifestation: a case report of sintilimab-induced ureteritis/cystitis treated by ureteral stent and review of the literature |
| title_full_unstemmed | Immune-related adverse events with renal colic as the main manifestation: a case report of sintilimab-induced ureteritis/cystitis treated by ureteral stent and review of the literature |
| title_short | Immune-related adverse events with renal colic as the main manifestation: a case report of sintilimab-induced ureteritis/cystitis treated by ureteral stent and review of the literature |
| title_sort | immune related adverse events with renal colic as the main manifestation a case report of sintilimab induced ureteritis cystitis treated by ureteral stent and review of the literature |
| topic | immune checkpoint inhibitors (ICIs) immune-related adverse events (irAEs) sintilimab ureteritis/cystitis ureteral stent |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1501415/full |
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