Chemoprotection and Immunostimulation of Alpha-Lipoic Acid Against Chlorpyrifos-Induced Toxicosis in Nile Tilapia, Oreochromis niloticus
This paper examined the chemoprotective and immunomodulatory effects of alpha-lipoic acid (ALA) against chlorpyrifos (CPL)-induced toxicosis in Nile tilapia, Oreochromis niloticus. Fish (n = 120, mean weight = 8.8 ± 0.6 g) were divided into 12 tanks (100-L capacity, 10 fish/tank) to represent two gr...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Scientifica |
| Online Access: | http://dx.doi.org/10.1155/sci5/9985059 |
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| author | Bilal A. Paray Eijaz A. Bhat Abdulkadir O. Adebayo Femi J. Fawole Ibrahim Adeshina |
| author_facet | Bilal A. Paray Eijaz A. Bhat Abdulkadir O. Adebayo Femi J. Fawole Ibrahim Adeshina |
| author_sort | Bilal A. Paray |
| collection | DOAJ |
| description | This paper examined the chemoprotective and immunomodulatory effects of alpha-lipoic acid (ALA) against chlorpyrifos (CPL)-induced toxicosis in Nile tilapia, Oreochromis niloticus. Fish (n = 120, mean weight = 8.8 ± 0.6 g) were divided into 12 tanks (100-L capacity, 10 fish/tank) to represent two groups. Group 1 (60 fish) was fed a diet (300 g/kg crude protein) containing 40 mg ALA/kg feed, while Group 2 (60 fish) was fed a basal diet without ALA. Then, 30 fish from each group were exposed to 450 μg CPL/L. Thus, the experimental treatments were control, CPL (basal diet and exposed to CPL), ALA (ALA-based diet), and ALA + CPL (ALA-based and exposed to CPL) for 14 days. Fish fed with ALA alone showed significantly (p=0.001) higher survival rates (100%), improved hematological and biochemical profiles, enhanced antioxidant activity, and stronger immune responses than CPL-exposed fish alone. CPL exposure caused severe physiological disorders and histological damage, particularly in the liver. However, ALA + CPL interactions mitigated these adverse effects, restoring tissue integrity and functionality. The findings underscore ALA’s potential as a dietary intervention to reduce environmental toxicant-induced stress in aquaculture, improving fish health and resilience against toxins. |
| format | Article |
| id | doaj-art-9c0291d49e264f47b5f62a0a221d6e35 |
| institution | Kabale University |
| issn | 2090-908X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
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| series | Scientifica |
| spelling | doaj-art-9c0291d49e264f47b5f62a0a221d6e352025-08-20T03:50:54ZengWileyScientifica2090-908X2025-01-01202510.1155/sci5/9985059Chemoprotection and Immunostimulation of Alpha-Lipoic Acid Against Chlorpyrifos-Induced Toxicosis in Nile Tilapia, Oreochromis niloticusBilal A. Paray0Eijaz A. Bhat1Abdulkadir O. Adebayo2Femi J. Fawole3Ibrahim Adeshina4Department of ZoologyMicrobiology/Molecular Physiology of ProkaryotesDepartment of Aquaculture and FisheriesDepartment of Aquaculture and FisheriesDepartment of Aquaculture and FisheriesThis paper examined the chemoprotective and immunomodulatory effects of alpha-lipoic acid (ALA) against chlorpyrifos (CPL)-induced toxicosis in Nile tilapia, Oreochromis niloticus. Fish (n = 120, mean weight = 8.8 ± 0.6 g) were divided into 12 tanks (100-L capacity, 10 fish/tank) to represent two groups. Group 1 (60 fish) was fed a diet (300 g/kg crude protein) containing 40 mg ALA/kg feed, while Group 2 (60 fish) was fed a basal diet without ALA. Then, 30 fish from each group were exposed to 450 μg CPL/L. Thus, the experimental treatments were control, CPL (basal diet and exposed to CPL), ALA (ALA-based diet), and ALA + CPL (ALA-based and exposed to CPL) for 14 days. Fish fed with ALA alone showed significantly (p=0.001) higher survival rates (100%), improved hematological and biochemical profiles, enhanced antioxidant activity, and stronger immune responses than CPL-exposed fish alone. CPL exposure caused severe physiological disorders and histological damage, particularly in the liver. However, ALA + CPL interactions mitigated these adverse effects, restoring tissue integrity and functionality. The findings underscore ALA’s potential as a dietary intervention to reduce environmental toxicant-induced stress in aquaculture, improving fish health and resilience against toxins.http://dx.doi.org/10.1155/sci5/9985059 |
| spellingShingle | Bilal A. Paray Eijaz A. Bhat Abdulkadir O. Adebayo Femi J. Fawole Ibrahim Adeshina Chemoprotection and Immunostimulation of Alpha-Lipoic Acid Against Chlorpyrifos-Induced Toxicosis in Nile Tilapia, Oreochromis niloticus Scientifica |
| title | Chemoprotection and Immunostimulation of Alpha-Lipoic Acid Against Chlorpyrifos-Induced Toxicosis in Nile Tilapia, Oreochromis niloticus |
| title_full | Chemoprotection and Immunostimulation of Alpha-Lipoic Acid Against Chlorpyrifos-Induced Toxicosis in Nile Tilapia, Oreochromis niloticus |
| title_fullStr | Chemoprotection and Immunostimulation of Alpha-Lipoic Acid Against Chlorpyrifos-Induced Toxicosis in Nile Tilapia, Oreochromis niloticus |
| title_full_unstemmed | Chemoprotection and Immunostimulation of Alpha-Lipoic Acid Against Chlorpyrifos-Induced Toxicosis in Nile Tilapia, Oreochromis niloticus |
| title_short | Chemoprotection and Immunostimulation of Alpha-Lipoic Acid Against Chlorpyrifos-Induced Toxicosis in Nile Tilapia, Oreochromis niloticus |
| title_sort | chemoprotection and immunostimulation of alpha lipoic acid against chlorpyrifos induced toxicosis in nile tilapia oreochromis niloticus |
| url | http://dx.doi.org/10.1155/sci5/9985059 |
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