Hydrogel carrier with bubble vibration enhancer for ultrasound-triggered drug release
Hydrogel-based drug carriers provide on-demand drug release via external stimuli. Ultrasound is a promising method because of the potential for remotely releasing the drug. However, intense ultrasound irradiation has been required in previous studies. This paper reports drug model release from hydro...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Ultrasonics Sonochemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S135041772400422X |
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| _version_ | 1841545998689632256 |
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| author | Ryuto Yamakawa Hiroaki Onoe Yuta Kurashina |
| author_facet | Ryuto Yamakawa Hiroaki Onoe Yuta Kurashina |
| author_sort | Ryuto Yamakawa |
| collection | DOAJ |
| description | Hydrogel-based drug carriers provide on-demand drug release via external stimuli. Ultrasound is a promising method because of the potential for remotely releasing the drug. However, intense ultrasound irradiation has been required in previous studies. This paper reports drug model release from hydrogel carriers encapsulating bubble vibration enhancers (BVEs) consisting of microbubbles coated with a lipid membrane. Vibration of BVEs induced by ultrasound stimulation promoted the release of drug models with ultrasound irradiation controlled to a biologically safe acoustic pressure based on spatial-peak temporal-average intensity (ISPTA). The release ratio increased significantly from 2.3 % without BVEs and ultrasound to 10.2 % with both. To evaluate the frequency response, the release ratio was measured at three different ultrasound frequencies (0.3, 1.8, and 2.5 MHz), showing increased efficiency as the frequency approached the resonance frequency of the BVEs. For in vivo applications, hydrogel microspherical carriers with BVEs achieved a 12 % release ratio. Poly-L-lysine coating successfully suppressed the drug release to 0.2 %. The carriers demonstrated repeated responsiveness when ultrasound was applied in three 5-minute intervals. The hydrogel carrier encapsulating BVEs we proposed is a promising in vivo device capable of releasing drugs on demand by ultrasound irradiation based on its high biosafety and acoustic responsiveness. |
| format | Article |
| id | doaj-art-9be4fa54560e407bb50fdca7dd4060ee |
| institution | Kabale University |
| issn | 1350-4177 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ultrasonics Sonochemistry |
| spelling | doaj-art-9be4fa54560e407bb50fdca7dd4060ee2025-01-11T06:38:44ZengElsevierUltrasonics Sonochemistry1350-41772025-01-01112107173Hydrogel carrier with bubble vibration enhancer for ultrasound-triggered drug releaseRyuto Yamakawa0Hiroaki Onoe1Yuta Kurashina2Division of Advanced Mechanical Systems Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei-shi, Tokyo 184–8588, JapanFaculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, JapanDivision of Advanced Mechanical Systems Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei-shi, Tokyo 184–8588, Japan; Corresponding author.Hydrogel-based drug carriers provide on-demand drug release via external stimuli. Ultrasound is a promising method because of the potential for remotely releasing the drug. However, intense ultrasound irradiation has been required in previous studies. This paper reports drug model release from hydrogel carriers encapsulating bubble vibration enhancers (BVEs) consisting of microbubbles coated with a lipid membrane. Vibration of BVEs induced by ultrasound stimulation promoted the release of drug models with ultrasound irradiation controlled to a biologically safe acoustic pressure based on spatial-peak temporal-average intensity (ISPTA). The release ratio increased significantly from 2.3 % without BVEs and ultrasound to 10.2 % with both. To evaluate the frequency response, the release ratio was measured at three different ultrasound frequencies (0.3, 1.8, and 2.5 MHz), showing increased efficiency as the frequency approached the resonance frequency of the BVEs. For in vivo applications, hydrogel microspherical carriers with BVEs achieved a 12 % release ratio. Poly-L-lysine coating successfully suppressed the drug release to 0.2 %. The carriers demonstrated repeated responsiveness when ultrasound was applied in three 5-minute intervals. The hydrogel carrier encapsulating BVEs we proposed is a promising in vivo device capable of releasing drugs on demand by ultrasound irradiation based on its high biosafety and acoustic responsiveness.http://www.sciencedirect.com/science/article/pii/S135041772400422XUltrasoundDrug releaseHydrogelAcoustic responsivenessBiocompatibility |
| spellingShingle | Ryuto Yamakawa Hiroaki Onoe Yuta Kurashina Hydrogel carrier with bubble vibration enhancer for ultrasound-triggered drug release Ultrasonics Sonochemistry Ultrasound Drug release Hydrogel Acoustic responsiveness Biocompatibility |
| title | Hydrogel carrier with bubble vibration enhancer for ultrasound-triggered drug release |
| title_full | Hydrogel carrier with bubble vibration enhancer for ultrasound-triggered drug release |
| title_fullStr | Hydrogel carrier with bubble vibration enhancer for ultrasound-triggered drug release |
| title_full_unstemmed | Hydrogel carrier with bubble vibration enhancer for ultrasound-triggered drug release |
| title_short | Hydrogel carrier with bubble vibration enhancer for ultrasound-triggered drug release |
| title_sort | hydrogel carrier with bubble vibration enhancer for ultrasound triggered drug release |
| topic | Ultrasound Drug release Hydrogel Acoustic responsiveness Biocompatibility |
| url | http://www.sciencedirect.com/science/article/pii/S135041772400422X |
| work_keys_str_mv | AT ryutoyamakawa hydrogelcarrierwithbubblevibrationenhancerforultrasoundtriggereddrugrelease AT hiroakionoe hydrogelcarrierwithbubblevibrationenhancerforultrasoundtriggereddrugrelease AT yutakurashina hydrogelcarrierwithbubblevibrationenhancerforultrasoundtriggereddrugrelease |