Prevalence and factors associated with neonatal sepsis in Mali: a cross-sectional study
Objective This study aimed to assess the prevalence and risk factors for neonatal sepsis among neonates admitted to selected health facilities in the Bamako district and Koulikoro region in Mali.Design This is a prospective cross-sectional study. Data were analyses using bivariate and multivariate l...
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BMJ Publishing Group
2025-01-01
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| Online Access: | https://bmjopen.bmj.com/content/15/1/e082066.full |
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| author | Bienvenu Salim Camara Alexandre Delamou Haoua Dembele Hamadoun Sangho Birama Apho Ly Sidikiba Sidibé Alioune Camara Cheick Sidya Sidibé Alhassane Diallo Abdoulaye Touré Fatoumata Bintou Traoré Elhadj Marouf Diallo Fatimata Yaro Mariam Traoré |
| author_facet | Bienvenu Salim Camara Alexandre Delamou Haoua Dembele Hamadoun Sangho Birama Apho Ly Sidikiba Sidibé Alioune Camara Cheick Sidya Sidibé Alhassane Diallo Abdoulaye Touré Fatoumata Bintou Traoré Elhadj Marouf Diallo Fatimata Yaro Mariam Traoré |
| author_sort | Bienvenu Salim Camara |
| collection | DOAJ |
| description | Objective This study aimed to assess the prevalence and risk factors for neonatal sepsis among neonates admitted to selected health facilities in the Bamako district and Koulikoro region in Mali.Design This is a prospective cross-sectional study. Data were analyses using bivariate and multivariate logistic regression.Setting This facility-based study was conducted in four health facilities consisting of two hospitals and two reference health centres in Mali.Participants The study participants comprised 795 randomly selected neonates and their indexed mother.Outcome measures The primary outcome of the study was the prevalence of sepsis in the considered health facilities. The other variables of interest were risk factors for sepsis.Results The prevalence of neonatal sepsis among the study population was 21.00%. More than 74% of sepsis cases were early onset (<72 hours). Neonatal age <7 days (AOR=2.79, 95% CI 1.59 to 4.89, p=0.000), low birth weight <2500 g (AOR=2.88, 95% CI 1.41 to 5.86, p=0.003), Apgar score <7 (AOR=4.03, 95% CI 3.09 to 5.24, p=0.000), mother with no education (AOR=2.24, 95% CI 1.15 to 4.33, p=0.02), maternal fever (AOR=2.31, 95% CI 1.53 to 3.53, p=0.000), prolonged rupture of membranes (AOR=1.87, 95% CI 1.01 to 3.54, p=0.04) and prolonged labour (AOR=2, 95% CI 1.03 to 3.88, p=0.04) were significantly associated with neonatal sepsis.Conclusion The prevalence of sepsis in Mali is still high. Given the country’s current security context, the findings in this study can support prevention activities, particularly given the limited resources available. It is essential to facilitate antenatal and postnatal visits, to promote in-facility births and rigorous monitoring of neonates at high risk of sepsis. Furthermore, it would be beneficial for future research on neonatal sepsis to include neonates born at home. |
| format | Article |
| id | doaj-art-9ba425dc109a4468becc4e03f9035ac1 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMJ Publishing Group |
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| spelling | doaj-art-9ba425dc109a4468becc4e03f9035ac12025-01-09T16:35:08ZengBMJ Publishing GroupBMJ Open2044-60552025-01-0115110.1136/bmjopen-2023-082066Prevalence and factors associated with neonatal sepsis in Mali: a cross-sectional studyBienvenu Salim Camara0Alexandre Delamou1Haoua Dembele2Hamadoun Sangho3Birama Apho Ly4Sidikiba Sidibé5Alioune Camara6Cheick Sidya Sidibé7Alhassane Diallo8Abdoulaye Touré9Fatoumata Bintou Traoré10Elhadj Marouf Diallo11Fatimata Yaro12Mariam Traoré133 UGANC, Conakry, Guinea4 African Centre of Excellence for the Prevention and Control of Communicable Diseases, University of Conakry, Conakry, Guinea9 National Institute of Public Health, Bamako, Mali8 USTTB FMOS, Bamako, Mali8 USTTB FMOS, Bamako, Mali7 University of Conakry, Department of Public Health, Universite Gamal Abdel Nasser de Conakry, Faculte des Sciences et Techniques de la Sante, Conakry, Guinea11 National Malaria Control Programme, Guinea, Conakry, Guinea5 Vrije Universiteit Amsterdam Athena Instituut, Amsterdam, North Holland, The Netherlands6 Université Montpellier 1, Montpellier, Occitanie, France10 Center of Research and Training in Infectious Diseases, Gamal Abdel Nasser University of Conakry, Conakry, Guinea1 Gamal Abdel Nasser University of Conakry, Conakry, Guinea4 African Centre of Excellence for the Prevention and Control of Communicable Diseases, University of Conakry, Conakry, Guinea9 National Institute of Public Health, Bamako, Mali9 National Institute of Public Health, Bamako, MaliObjective This study aimed to assess the prevalence and risk factors for neonatal sepsis among neonates admitted to selected health facilities in the Bamako district and Koulikoro region in Mali.Design This is a prospective cross-sectional study. Data were analyses using bivariate and multivariate logistic regression.Setting This facility-based study was conducted in four health facilities consisting of two hospitals and two reference health centres in Mali.Participants The study participants comprised 795 randomly selected neonates and their indexed mother.Outcome measures The primary outcome of the study was the prevalence of sepsis in the considered health facilities. The other variables of interest were risk factors for sepsis.Results The prevalence of neonatal sepsis among the study population was 21.00%. More than 74% of sepsis cases were early onset (<72 hours). Neonatal age <7 days (AOR=2.79, 95% CI 1.59 to 4.89, p=0.000), low birth weight <2500 g (AOR=2.88, 95% CI 1.41 to 5.86, p=0.003), Apgar score <7 (AOR=4.03, 95% CI 3.09 to 5.24, p=0.000), mother with no education (AOR=2.24, 95% CI 1.15 to 4.33, p=0.02), maternal fever (AOR=2.31, 95% CI 1.53 to 3.53, p=0.000), prolonged rupture of membranes (AOR=1.87, 95% CI 1.01 to 3.54, p=0.04) and prolonged labour (AOR=2, 95% CI 1.03 to 3.88, p=0.04) were significantly associated with neonatal sepsis.Conclusion The prevalence of sepsis in Mali is still high. Given the country’s current security context, the findings in this study can support prevention activities, particularly given the limited resources available. It is essential to facilitate antenatal and postnatal visits, to promote in-facility births and rigorous monitoring of neonates at high risk of sepsis. Furthermore, it would be beneficial for future research on neonatal sepsis to include neonates born at home.https://bmjopen.bmj.com/content/15/1/e082066.full |
| spellingShingle | Bienvenu Salim Camara Alexandre Delamou Haoua Dembele Hamadoun Sangho Birama Apho Ly Sidikiba Sidibé Alioune Camara Cheick Sidya Sidibé Alhassane Diallo Abdoulaye Touré Fatoumata Bintou Traoré Elhadj Marouf Diallo Fatimata Yaro Mariam Traoré Prevalence and factors associated with neonatal sepsis in Mali: a cross-sectional study BMJ Open |
| title | Prevalence and factors associated with neonatal sepsis in Mali: a cross-sectional study |
| title_full | Prevalence and factors associated with neonatal sepsis in Mali: a cross-sectional study |
| title_fullStr | Prevalence and factors associated with neonatal sepsis in Mali: a cross-sectional study |
| title_full_unstemmed | Prevalence and factors associated with neonatal sepsis in Mali: a cross-sectional study |
| title_short | Prevalence and factors associated with neonatal sepsis in Mali: a cross-sectional study |
| title_sort | prevalence and factors associated with neonatal sepsis in mali a cross sectional study |
| url | https://bmjopen.bmj.com/content/15/1/e082066.full |
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