Autonomic function and change in functional capacity in older adults: a longitudinal investigation
Abstract Functional capacity is an important objective health metric, and relies on the maintenance of physiological homeostasis. Autonomic nervous system is known to coordinates the maintenance of multi-organ homeostasis. The objective of this study was to examine the association of autonomic nervo...
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Nature Portfolio
2024-11-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-80659-w |
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| author | I-Chien Wu Yung-Yi Lu Wei-Ting Tseng Pei-Fen Chen |
| author_facet | I-Chien Wu Yung-Yi Lu Wei-Ting Tseng Pei-Fen Chen |
| author_sort | I-Chien Wu |
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| description | Abstract Functional capacity is an important objective health metric, and relies on the maintenance of physiological homeostasis. Autonomic nervous system is known to coordinates the maintenance of multi-organ homeostasis. The objective of this study was to examine the association of autonomic nervous system function with functional capacity in adults aged 55 years and older. A cohort of 542 adults (mean age of 70.1 years) received repeated measurements of heart rate variability, an autonomic nervous system function marker, and chair rise time, a functional capacity measure. Linear mixed models analysis showed that 1 SD lower powers in low-frequency range at baseline was associated with a 0.11 (95% CI 0.01–0.21) s/year faster increase in chair rise time during the follow-up, whereas 1 SD increase in powers in high-frequency range and 1 SD decrease in the ratio of powers in low-frequency range to powers in high-frequency range during the follow-up were associated with a 0.22 (95% CI 0.06–0.39) s and 0.17 (95% CI 0.01–0.33) s increase in chair rise time. In conclusion, autonomic nervous system function and its changes were longitudinally associated with changes in functional capacity in older adults. |
| format | Article |
| id | doaj-art-9b91147ab9b54a45a8d7c11cb0d83ecd |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-9b91147ab9b54a45a8d7c11cb0d83ecd2024-11-24T12:23:25ZengNature PortfolioScientific Reports2045-23222024-11-011411910.1038/s41598-024-80659-wAutonomic function and change in functional capacity in older adults: a longitudinal investigationI-Chien Wu0Yung-Yi Lu1Wei-Ting Tseng2Pei-Fen Chen3Institute of Population Health Sciences, National Health Research Institutes, Miaoli CountyInstitute of Population Health Sciences, National Health Research Institutes, Miaoli CountyInstitute of Population Health Sciences, National Health Research Institutes, Miaoli CountyInstitute of Population Health Sciences, National Health Research Institutes, Miaoli CountyAbstract Functional capacity is an important objective health metric, and relies on the maintenance of physiological homeostasis. Autonomic nervous system is known to coordinates the maintenance of multi-organ homeostasis. The objective of this study was to examine the association of autonomic nervous system function with functional capacity in adults aged 55 years and older. A cohort of 542 adults (mean age of 70.1 years) received repeated measurements of heart rate variability, an autonomic nervous system function marker, and chair rise time, a functional capacity measure. Linear mixed models analysis showed that 1 SD lower powers in low-frequency range at baseline was associated with a 0.11 (95% CI 0.01–0.21) s/year faster increase in chair rise time during the follow-up, whereas 1 SD increase in powers in high-frequency range and 1 SD decrease in the ratio of powers in low-frequency range to powers in high-frequency range during the follow-up were associated with a 0.22 (95% CI 0.06–0.39) s and 0.17 (95% CI 0.01–0.33) s increase in chair rise time. In conclusion, autonomic nervous system function and its changes were longitudinally associated with changes in functional capacity in older adults.https://doi.org/10.1038/s41598-024-80659-wHealthy agingLongitudinal studiesAdultsAutonomic nervous systemPhysical functioningMuscle strength |
| spellingShingle | I-Chien Wu Yung-Yi Lu Wei-Ting Tseng Pei-Fen Chen Autonomic function and change in functional capacity in older adults: a longitudinal investigation Scientific Reports Healthy aging Longitudinal studies Adults Autonomic nervous system Physical functioning Muscle strength |
| title | Autonomic function and change in functional capacity in older adults: a longitudinal investigation |
| title_full | Autonomic function and change in functional capacity in older adults: a longitudinal investigation |
| title_fullStr | Autonomic function and change in functional capacity in older adults: a longitudinal investigation |
| title_full_unstemmed | Autonomic function and change in functional capacity in older adults: a longitudinal investigation |
| title_short | Autonomic function and change in functional capacity in older adults: a longitudinal investigation |
| title_sort | autonomic function and change in functional capacity in older adults a longitudinal investigation |
| topic | Healthy aging Longitudinal studies Adults Autonomic nervous system Physical functioning Muscle strength |
| url | https://doi.org/10.1038/s41598-024-80659-w |
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