Central Role of Hypothalamic Circuits for Acupuncture's Anti‐Parkinsonian Effects
Abstract Despite clinical data stretching over millennia, the neurobiological basis of the effectiveness of acupuncture in treating diseases of the central nervous system has remained elusive. Here, using an established model of acupuncture treatment in Parkinson's disease (PD) model mice, we s...
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| Language: | English |
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Wiley
2024-11-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202403245 |
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| author | Ju‐Young Oh Hyowon Lee Sun‐Young Jang Hyunjin Kim Geunhong Park Almas Serikov Jae‐Hwan Jang Junyeop Kim Seulkee Yang Moonsun Sa Sung Eun Lee Young‐Eun Han Tae‐Yeon Hwang Sharon Jiyoon Jung Hee Young Kim Seung Eun Lee Soo‐Jin Oh Jeongjin Kim Jeongyeon Kim Jongpil Kim Thomas J. McHugh C. Justin Lee Min‐Ho Nam Hi‐Joon Park |
| author_facet | Ju‐Young Oh Hyowon Lee Sun‐Young Jang Hyunjin Kim Geunhong Park Almas Serikov Jae‐Hwan Jang Junyeop Kim Seulkee Yang Moonsun Sa Sung Eun Lee Young‐Eun Han Tae‐Yeon Hwang Sharon Jiyoon Jung Hee Young Kim Seung Eun Lee Soo‐Jin Oh Jeongjin Kim Jeongyeon Kim Jongpil Kim Thomas J. McHugh C. Justin Lee Min‐Ho Nam Hi‐Joon Park |
| author_sort | Ju‐Young Oh |
| collection | DOAJ |
| description | Abstract Despite clinical data stretching over millennia, the neurobiological basis of the effectiveness of acupuncture in treating diseases of the central nervous system has remained elusive. Here, using an established model of acupuncture treatment in Parkinson's disease (PD) model mice, we show that peripheral acupuncture stimulation activates hypothalamic melanin‐concentrating hormone (MCH) neurons via nerve conduction. We further identify two separate neural pathways originating from anatomically and electrophysiologically distinct MCH neuronal subpopulations, projecting to the substantia nigra and hippocampus, respectively. Through chemogenetic manipulation specifically targeting these MCH projections, their respective roles in mediating the acupuncture‐induced motor recovery and memory improvements following PD onset are demonstrated, as well as the underlying mechanisms mediating recovery from dopaminergic neurodegeneration, reactive gliosis, and impaired hippocampal synaptic plasticity. Collectively, these MCH neurons constitute not only a circuit‐based explanation for the therapeutic effectiveness of traditional acupuncture, but also a potential cellular target for treating both motor and non‐motor PD symptoms. |
| format | Article |
| id | doaj-art-9b8a1679853d479eadeed71cd1449eaf |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-9b8a1679853d479eadeed71cd1449eaf2024-11-20T19:25:40ZengWileyAdvanced Science2198-38442024-11-011143n/an/a10.1002/advs.202403245Central Role of Hypothalamic Circuits for Acupuncture's Anti‐Parkinsonian EffectsJu‐Young Oh0Hyowon Lee1Sun‐Young Jang2Hyunjin Kim3Geunhong Park4Almas Serikov5Jae‐Hwan Jang6Junyeop Kim7Seulkee Yang8Moonsun Sa9Sung Eun Lee10Young‐Eun Han11Tae‐Yeon Hwang12Sharon Jiyoon Jung13Hee Young Kim14Seung Eun Lee15Soo‐Jin Oh16Jeongjin Kim17Jeongyeon Kim18Jongpil Kim19Thomas J. McHugh20C. Justin Lee21Min‐Ho Nam22Hi‐Joon Park23College of Korean Medicine Kyung Hee University Seoul 02447 Republic of KoreaCollege of Korean Medicine Kyung Hee University Seoul 02447 Republic of KoreaCollege of Korean Medicine Kyung Hee University Seoul 02447 Republic of KoreaBrain Science Institute Korea Institute of Science and Technology (KIST) Seoul 02792 Republic of KoreaBrain Science Institute Korea Institute of Science and Technology (KIST) Seoul 02792 Republic of KoreaBrain Science Institute Korea Institute of Science and Technology (KIST) Seoul 02792 Republic of KoreaStudies of Translational Acupuncture Research (STAR) Kyung Hee University Seoul 02447 Republic of KoreaLaboratory of Stem Cells & Cell Reprogramming Department of Chemistry Dongguk University Seoul 04629 Republic of KoreaBrain Science Institute Korea Institute of Science and Technology (KIST) Seoul 02792 Republic of KoreaCenter for Cognition and Sociality Institute for Basic Science Daejeon 34126 Republic of KoreaCenter for Cognition and Sociality Institute for Basic Science Daejeon 34126 Republic of KoreaBrain Science Institute Korea Institute of Science and Technology (KIST) Seoul 02792 Republic of KoreaCollege of Korean Medicine Kyung Hee University Seoul 02447 Republic of KoreaTechnological Convergence Center Korea Institute of Science and Technology (KIST) Seoul 02792 Republic of KoreaDepartment of Physiology Yonsei University Seoul 03722 Republic of KoreaCenter for Cognition and Sociality Institute for Basic Science Daejeon 34126 Republic of KoreaBrain Science Institute Korea Institute of Science and Technology (KIST) Seoul 02792 Republic of KoreaBrain Science Institute Korea Institute of Science and Technology (KIST) Seoul 02792 Republic of KoreaEmotion, Cognition & Behavior Research Group Korea Brain Research Institute Daegu 41062 Republic of KoreaLaboratory of Stem Cells & Cell Reprogramming Department of Chemistry Dongguk University Seoul 04629 Republic of KoreaBrain Science Institute Korea Institute of Science and Technology (KIST) Seoul 02792 Republic of KoreaCenter for Cognition and Sociality Institute for Basic Science Daejeon 34126 Republic of KoreaBrain Science Institute Korea Institute of Science and Technology (KIST) Seoul 02792 Republic of KoreaCollege of Korean Medicine Kyung Hee University Seoul 02447 Republic of KoreaAbstract Despite clinical data stretching over millennia, the neurobiological basis of the effectiveness of acupuncture in treating diseases of the central nervous system has remained elusive. Here, using an established model of acupuncture treatment in Parkinson's disease (PD) model mice, we show that peripheral acupuncture stimulation activates hypothalamic melanin‐concentrating hormone (MCH) neurons via nerve conduction. We further identify two separate neural pathways originating from anatomically and electrophysiologically distinct MCH neuronal subpopulations, projecting to the substantia nigra and hippocampus, respectively. Through chemogenetic manipulation specifically targeting these MCH projections, their respective roles in mediating the acupuncture‐induced motor recovery and memory improvements following PD onset are demonstrated, as well as the underlying mechanisms mediating recovery from dopaminergic neurodegeneration, reactive gliosis, and impaired hippocampal synaptic plasticity. Collectively, these MCH neurons constitute not only a circuit‐based explanation for the therapeutic effectiveness of traditional acupuncture, but also a potential cellular target for treating both motor and non‐motor PD symptoms.https://doi.org/10.1002/advs.202403245acupuncturehypothalamusmelanin‐concentrating hormone (MCH)motor and non‐motor symptomsneural circuitryParkinson's disease (PD) |
| spellingShingle | Ju‐Young Oh Hyowon Lee Sun‐Young Jang Hyunjin Kim Geunhong Park Almas Serikov Jae‐Hwan Jang Junyeop Kim Seulkee Yang Moonsun Sa Sung Eun Lee Young‐Eun Han Tae‐Yeon Hwang Sharon Jiyoon Jung Hee Young Kim Seung Eun Lee Soo‐Jin Oh Jeongjin Kim Jeongyeon Kim Jongpil Kim Thomas J. McHugh C. Justin Lee Min‐Ho Nam Hi‐Joon Park Central Role of Hypothalamic Circuits for Acupuncture's Anti‐Parkinsonian Effects Advanced Science acupuncture hypothalamus melanin‐concentrating hormone (MCH) motor and non‐motor symptoms neural circuitry Parkinson's disease (PD) |
| title | Central Role of Hypothalamic Circuits for Acupuncture's Anti‐Parkinsonian Effects |
| title_full | Central Role of Hypothalamic Circuits for Acupuncture's Anti‐Parkinsonian Effects |
| title_fullStr | Central Role of Hypothalamic Circuits for Acupuncture's Anti‐Parkinsonian Effects |
| title_full_unstemmed | Central Role of Hypothalamic Circuits for Acupuncture's Anti‐Parkinsonian Effects |
| title_short | Central Role of Hypothalamic Circuits for Acupuncture's Anti‐Parkinsonian Effects |
| title_sort | central role of hypothalamic circuits for acupuncture s anti parkinsonian effects |
| topic | acupuncture hypothalamus melanin‐concentrating hormone (MCH) motor and non‐motor symptoms neural circuitry Parkinson's disease (PD) |
| url | https://doi.org/10.1002/advs.202403245 |
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