Role of waist circumference, body mass index and high-sensitivity C-reactive protein in pediatric steatotic liver disease: A cross-sectional study
Introduction and Objectives: Relationships and interactions among waist circumference (WC), body mass index (BMI) and high-sensitivity C-reactive protein (hs-CRP) with steatotic liver disease (SLD) in children have rarely been studied as a whole. We aimed to investigate the association among WC, BMI...
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Elsevier
2025-01-01
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| Series: | Annals of Hepatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268124005428 |
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| author | Qiaoling Wu Yongmei Peng Chundan Gong |
| author_facet | Qiaoling Wu Yongmei Peng Chundan Gong |
| author_sort | Qiaoling Wu |
| collection | DOAJ |
| description | Introduction and Objectives: Relationships and interactions among waist circumference (WC), body mass index (BMI) and high-sensitivity C-reactive protein (hs-CRP) with steatotic liver disease (SLD) in children have rarely been studied as a whole. We aimed to investigate the association among WC, BMI and hs-CRP with SLD and its related metabolic indictors. Materials and Methods: A total of 10,776 children aged 10–15 years were screened in our study. Anthropometric data, biochemical parameters and ultrasound assessments were collected. Metabolic indictors between children with and without SLD were compared. The correlation of waist circumference Z score (ZWC), body mass index Z score (ZBMI) and hs-CRP with SLD and its related metabolic indictors, and the interactive effect between ZWC with hs-CRP and ZBMI with hs-CRP upon SLD, respectively, was tested. Results: A total of 543 children with normal BMI (n = 287) and high BMI (n = 256) were examined. Hs-CRP, ZWC and ZBMI were all found to significantly correlate with SLD and its related metabolic indexes. The interaction effect analysis showed that ZWC and male was independent risk factor of SLD with OR (95 %CI) of 23.431 (7.253, 75.697) and 7.927 (2.766,22.713), respectively, whereas the same effect wasn't found in ZBMI. The cut-off value of ZWC for the prediction of SLD was 1.494 and 1.541 in boys and girls, respectively. Conclusions: Increased WC, BMI and hs-CRP exerts adverse effect in pediatric SLD and its related metabolic indictors. WC and male gender could be independent risk factors for SLD, and WC was a powerful index for the prediction of SLD in children aged 10–15 years. |
| format | Article |
| id | doaj-art-9b690bb5da33480d97d55f09bc3e4873 |
| institution | Kabale University |
| issn | 1665-2681 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj-art-9b690bb5da33480d97d55f09bc3e48732025-01-06T04:08:35ZengElsevierAnnals of Hepatology1665-26812025-01-01301101759Role of waist circumference, body mass index and high-sensitivity C-reactive protein in pediatric steatotic liver disease: A cross-sectional studyQiaoling Wu0Yongmei Peng1Chundan Gong2The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Corresponding author at: The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China; Shanghai key Laboratory of Embryo Original Diseases, Shanghai, 20030, ChinaChildren's Hospital of Fudan University, Shanghai, China; Shanghai Center for Women and Children's Health, Shanghai, China; Corresponding author at: Shanghai Center for Women and Children's Health, Shanghai, China.Children's Hospital of Fudan University, Shanghai, ChinaIntroduction and Objectives: Relationships and interactions among waist circumference (WC), body mass index (BMI) and high-sensitivity C-reactive protein (hs-CRP) with steatotic liver disease (SLD) in children have rarely been studied as a whole. We aimed to investigate the association among WC, BMI and hs-CRP with SLD and its related metabolic indictors. Materials and Methods: A total of 10,776 children aged 10–15 years were screened in our study. Anthropometric data, biochemical parameters and ultrasound assessments were collected. Metabolic indictors between children with and without SLD were compared. The correlation of waist circumference Z score (ZWC), body mass index Z score (ZBMI) and hs-CRP with SLD and its related metabolic indictors, and the interactive effect between ZWC with hs-CRP and ZBMI with hs-CRP upon SLD, respectively, was tested. Results: A total of 543 children with normal BMI (n = 287) and high BMI (n = 256) were examined. Hs-CRP, ZWC and ZBMI were all found to significantly correlate with SLD and its related metabolic indexes. The interaction effect analysis showed that ZWC and male was independent risk factor of SLD with OR (95 %CI) of 23.431 (7.253, 75.697) and 7.927 (2.766,22.713), respectively, whereas the same effect wasn't found in ZBMI. The cut-off value of ZWC for the prediction of SLD was 1.494 and 1.541 in boys and girls, respectively. Conclusions: Increased WC, BMI and hs-CRP exerts adverse effect in pediatric SLD and its related metabolic indictors. WC and male gender could be independent risk factors for SLD, and WC was a powerful index for the prediction of SLD in children aged 10–15 years.http://www.sciencedirect.com/science/article/pii/S1665268124005428Steatotic liver diseaseMetabolic dysfunction-associated steatotic liver diseaseChildrenInflammationGlycolipid metabolism |
| spellingShingle | Qiaoling Wu Yongmei Peng Chundan Gong Role of waist circumference, body mass index and high-sensitivity C-reactive protein in pediatric steatotic liver disease: A cross-sectional study Annals of Hepatology Steatotic liver disease Metabolic dysfunction-associated steatotic liver disease Children Inflammation Glycolipid metabolism |
| title | Role of waist circumference, body mass index and high-sensitivity C-reactive protein in pediatric steatotic liver disease: A cross-sectional study |
| title_full | Role of waist circumference, body mass index and high-sensitivity C-reactive protein in pediatric steatotic liver disease: A cross-sectional study |
| title_fullStr | Role of waist circumference, body mass index and high-sensitivity C-reactive protein in pediatric steatotic liver disease: A cross-sectional study |
| title_full_unstemmed | Role of waist circumference, body mass index and high-sensitivity C-reactive protein in pediatric steatotic liver disease: A cross-sectional study |
| title_short | Role of waist circumference, body mass index and high-sensitivity C-reactive protein in pediatric steatotic liver disease: A cross-sectional study |
| title_sort | role of waist circumference body mass index and high sensitivity c reactive protein in pediatric steatotic liver disease a cross sectional study |
| topic | Steatotic liver disease Metabolic dysfunction-associated steatotic liver disease Children Inflammation Glycolipid metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S1665268124005428 |
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