Effect of sleeve gastrectomy on cardiac inflammatory markers and early postoperative outcomes: A systematic review
Sleeve gastrectomies are widely used for weight loss and metabolic improvement in individuals with obesity. Although its effects on metabolic parameters are well established, its short-term impact on cardiac inflammatory markers and cardiovascular outcomes has not been clearly defined. This review e...
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Wolters Kluwer Medknow Publications
2025-07-01
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| Series: | Advances in Biomedical and Health Sciences |
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| Online Access: | https://journals.lww.com/10.4103/abhs.abhs_31_25 |
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| author | Abeer Majed Al Kusayer Hadia Radwan Dimitrios Papandreou Haydar Hasan |
| author_facet | Abeer Majed Al Kusayer Hadia Radwan Dimitrios Papandreou Haydar Hasan |
| author_sort | Abeer Majed Al Kusayer |
| collection | DOAJ |
| description | Sleeve gastrectomies are widely used for weight loss and metabolic improvement in individuals with obesity. Although its effects on metabolic parameters are well established, its short-term impact on cardiac inflammatory markers and cardiovascular outcomes has not been clearly defined. This review examined how sleeve gastrectomy influences markers such as C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), adiponectin, and leptin hormones, along with associated cardiovascular indicators. We conducted a systematic review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses PRISMA guidelines. Articles published from January 2012 to January 2025 were retrieved from PubMed, Embase (Ovid), Cochrane, and Scopus databases. Eligible studies included clinical trials and cohort studies involving adults who underwent sleeve gastrectomy with follow-up data on inflammatory or cardiovascular markers. Twenty-six studies involving 1269 patients met the inclusion criteria. Most studies have shown reductions in CRP and leptin levels within the 1st year after surgery. TNF-α and IL-6 showed variable changes, whereas adiponectin increased in several reports. Improvements in blood pressure, glycemic control, and lipid profiles are common. A few studies have also reported early changes in cardiac structure or vascular markers. Sleeve gastrectomy is associated with the early improvement of systemic inflammation and cardiometabolic risk factors. However, the short follow-up duration, variations in measurement techniques, and limited cardiac imaging restrict broader conclusions. Further research is needed to clarify the long-term cardiovascular effects and standardize the assessment of inflammatory outcomes. |
| format | Article |
| id | doaj-art-9b68d15b84d04fc09c806bd0dfb1749d |
| institution | Kabale University |
| issn | 2773-1545 2773-1553 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Advances in Biomedical and Health Sciences |
| spelling | doaj-art-9b68d15b84d04fc09c806bd0dfb1749d2025-08-20T04:02:17ZengWolters Kluwer Medknow PublicationsAdvances in Biomedical and Health Sciences2773-15452773-15532025-07-01439910810.4103/abhs.abhs_31_25Effect of sleeve gastrectomy on cardiac inflammatory markers and early postoperative outcomes: A systematic reviewAbeer Majed Al KusayerHadia RadwanDimitrios PapandreouHaydar HasanSleeve gastrectomies are widely used for weight loss and metabolic improvement in individuals with obesity. Although its effects on metabolic parameters are well established, its short-term impact on cardiac inflammatory markers and cardiovascular outcomes has not been clearly defined. This review examined how sleeve gastrectomy influences markers such as C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), adiponectin, and leptin hormones, along with associated cardiovascular indicators. We conducted a systematic review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses PRISMA guidelines. Articles published from January 2012 to January 2025 were retrieved from PubMed, Embase (Ovid), Cochrane, and Scopus databases. Eligible studies included clinical trials and cohort studies involving adults who underwent sleeve gastrectomy with follow-up data on inflammatory or cardiovascular markers. Twenty-six studies involving 1269 patients met the inclusion criteria. Most studies have shown reductions in CRP and leptin levels within the 1st year after surgery. TNF-α and IL-6 showed variable changes, whereas adiponectin increased in several reports. Improvements in blood pressure, glycemic control, and lipid profiles are common. A few studies have also reported early changes in cardiac structure or vascular markers. Sleeve gastrectomy is associated with the early improvement of systemic inflammation and cardiometabolic risk factors. However, the short follow-up duration, variations in measurement techniques, and limited cardiac imaging restrict broader conclusions. Further research is needed to clarify the long-term cardiovascular effects and standardize the assessment of inflammatory outcomes.https://journals.lww.com/10.4103/abhs.abhs_31_25bariatric surgerycardiovascular functionc-reactive proteininflammatory markerssleeve gastrectomytumor necrosis factor-alpha |
| spellingShingle | Abeer Majed Al Kusayer Hadia Radwan Dimitrios Papandreou Haydar Hasan Effect of sleeve gastrectomy on cardiac inflammatory markers and early postoperative outcomes: A systematic review Advances in Biomedical and Health Sciences bariatric surgery cardiovascular function c-reactive protein inflammatory markers sleeve gastrectomy tumor necrosis factor-alpha |
| title | Effect of sleeve gastrectomy on cardiac inflammatory markers and early postoperative outcomes: A systematic review |
| title_full | Effect of sleeve gastrectomy on cardiac inflammatory markers and early postoperative outcomes: A systematic review |
| title_fullStr | Effect of sleeve gastrectomy on cardiac inflammatory markers and early postoperative outcomes: A systematic review |
| title_full_unstemmed | Effect of sleeve gastrectomy on cardiac inflammatory markers and early postoperative outcomes: A systematic review |
| title_short | Effect of sleeve gastrectomy on cardiac inflammatory markers and early postoperative outcomes: A systematic review |
| title_sort | effect of sleeve gastrectomy on cardiac inflammatory markers and early postoperative outcomes a systematic review |
| topic | bariatric surgery cardiovascular function c-reactive protein inflammatory markers sleeve gastrectomy tumor necrosis factor-alpha |
| url | https://journals.lww.com/10.4103/abhs.abhs_31_25 |
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