MicroRNA-132 regulates quinolinic acid production in the brain during LPS-induced neuroinflammation

MicroRNA-132 regulates quinolinic acid production in the brain during LPS-induced neuroinflammation

BackgroundThe kynurenine pathway (KP) plays a major role in neuroinflammation by converting the amino acid tryptophan into a variety of neuroactive products, including neurotoxic quinolinic acid (QUIN). The gene expression regulatory role of microRNAs in neuroinflammation is well documented; however...

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Bibliographic Details
Main Authors:	Amir Mohamed Kezai, Papa Yaya Badiane, Benjamin Hennart, Delphine Allorge, Sabrina Marion, Sébastien S. Hébert
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-08-01
Series:	Frontiers in Immunology
Subjects:	microRNA-132 kynurenine pathway kynurenine 3-monooxygenase quinolinic acid neuroinflammation
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1644783/full
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