Mitochondrial plasticity: An emergent concept in neuronal plasticity and memory
Mitochondria are classically viewed as ‘on demand’ energy suppliers to neurons in support of their activity. In order to adapt to a wide range of demands, mitochondria need to be highly dynamic and capable of adjusting their metabolic activity, shape, and localization. Although these plastic propert...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Neurobiology of Disease |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996124003425 |
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| author | Typhaine Comyn Thomas Preat Alice Pavlowsky Pierre-Yves Plaçais |
| author_facet | Typhaine Comyn Thomas Preat Alice Pavlowsky Pierre-Yves Plaçais |
| author_sort | Typhaine Comyn |
| collection | DOAJ |
| description | Mitochondria are classically viewed as ‘on demand’ energy suppliers to neurons in support of their activity. In order to adapt to a wide range of demands, mitochondria need to be highly dynamic and capable of adjusting their metabolic activity, shape, and localization. Although these plastic properties give them a central support role in basal neuronal physiology, recent lines of evidence point toward a role for mitochondria in the regulation of high-order cognitive functions such as memory formation. In this review, we discuss the interplay between mitochondrial function and neural plasticity in sustaining memory formation at the molecular and cellular levels. First, we explore the global significance of mitochondria in memory formation. Then, we will detail the memory-relevant cellular and molecular mechanisms of mitochondrial plasticity. Finally, we focus on those mitochondrial functions, including but not limited to ATP production, that give mitochondria their pivotal role in memory formation. Altogether, this review highlights the central role of mitochondrial structural and functional plasticity in supporting and regulating neuronal plasticity and memory. |
| format | Article |
| id | doaj-art-9b4ca830f2884efe97bfeb4d0abd2f10 |
| institution | Kabale University |
| issn | 1095-953X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj-art-9b4ca830f2884efe97bfeb4d0abd2f102024-12-14T06:29:54ZengElsevierNeurobiology of Disease1095-953X2024-12-01203106740Mitochondrial plasticity: An emergent concept in neuronal plasticity and memoryTyphaine Comyn0Thomas Preat1Alice Pavlowsky2Pierre-Yves Plaçais3Energy & Memory, Brain Plasticity Unit, CNRS, ESPCI Paris, PSL Research University, 10 rue Vauquelin, 75005 Paris, FranceCorresponding authors.; Energy & Memory, Brain Plasticity Unit, CNRS, ESPCI Paris, PSL Research University, 10 rue Vauquelin, 75005 Paris, FranceCorresponding authors.; Energy & Memory, Brain Plasticity Unit, CNRS, ESPCI Paris, PSL Research University, 10 rue Vauquelin, 75005 Paris, FranceCorresponding authors.; Energy & Memory, Brain Plasticity Unit, CNRS, ESPCI Paris, PSL Research University, 10 rue Vauquelin, 75005 Paris, FranceMitochondria are classically viewed as ‘on demand’ energy suppliers to neurons in support of their activity. In order to adapt to a wide range of demands, mitochondria need to be highly dynamic and capable of adjusting their metabolic activity, shape, and localization. Although these plastic properties give them a central support role in basal neuronal physiology, recent lines of evidence point toward a role for mitochondria in the regulation of high-order cognitive functions such as memory formation. In this review, we discuss the interplay between mitochondrial function and neural plasticity in sustaining memory formation at the molecular and cellular levels. First, we explore the global significance of mitochondria in memory formation. Then, we will detail the memory-relevant cellular and molecular mechanisms of mitochondrial plasticity. Finally, we focus on those mitochondrial functions, including but not limited to ATP production, that give mitochondria their pivotal role in memory formation. Altogether, this review highlights the central role of mitochondrial structural and functional plasticity in supporting and regulating neuronal plasticity and memory.http://www.sciencedirect.com/science/article/pii/S0969996124003425Mitochondria dynamicsEnergyMemoryGliaTCA cycle |
| spellingShingle | Typhaine Comyn Thomas Preat Alice Pavlowsky Pierre-Yves Plaçais Mitochondrial plasticity: An emergent concept in neuronal plasticity and memory Neurobiology of Disease Mitochondria dynamics Energy Memory Glia TCA cycle |
| title | Mitochondrial plasticity: An emergent concept in neuronal plasticity and memory |
| title_full | Mitochondrial plasticity: An emergent concept in neuronal plasticity and memory |
| title_fullStr | Mitochondrial plasticity: An emergent concept in neuronal plasticity and memory |
| title_full_unstemmed | Mitochondrial plasticity: An emergent concept in neuronal plasticity and memory |
| title_short | Mitochondrial plasticity: An emergent concept in neuronal plasticity and memory |
| title_sort | mitochondrial plasticity an emergent concept in neuronal plasticity and memory |
| topic | Mitochondria dynamics Energy Memory Glia TCA cycle |
| url | http://www.sciencedirect.com/science/article/pii/S0969996124003425 |
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