Rationally designed multimeric nanovaccines using icosahedral DNA origami for display of SARS-CoV-2 receptor binding domain

Rationally designed multimeric nanovaccines using icosahedral DNA origami for display of SARS-CoV-2 receptor binding domain

Abstract Multivalent antigen display on nanoparticles can enhance the immunogenicity of nanovaccines targeting viral moieties, such as the receptor binding domain (RBD) of SARS-CoV-2. However, particle morphology and size of current nanovaccines are significantly different from those of SARS-CoV-2....

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Bibliographic Details
Main Authors: Qingqing Feng, Keman Cheng, Lizhuo Zhang, Dongshu Wang, Xiaoyu Gao, Jie Liang, Guangna Liu, Nana Ma, Chen Xu, Ming Tang, Liting Chen, Xinwei Wang, Xuehui Ma, Jiajia Zou, Quanwei Shi, Pei Du, Qihui Wang, Hengliang Wang, Guangjun Nie, Xiao Zhao
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-53937-4
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