Modern treatment methods in atopic dermatitis - literature overview
Introduction and aim: Atopic dermatitis (AD) is a chronic inflammatory skin disease. It is characterised by periods of exacerbation and remission of symptoms such as pruritus, dry skin and eczematous lesions with characteristic morphology. The aim of this study is to present the current state of kn...
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| Format: | Article |
| Language: | English |
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Kazimierz Wielki University
2025-01-01
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| Series: | Journal of Education, Health and Sport |
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| Online Access: | https://apcz.umk.pl/JEHS/article/view/56830 |
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| author | Martyna Borowska-Łygan Jakub Tomaszewski Wojciech Urban Konrad Strużek Jan Biłogras Kornelia Karamus Rafał Wojciech Rejmak |
| author_facet | Martyna Borowska-Łygan Jakub Tomaszewski Wojciech Urban Konrad Strużek Jan Biłogras Kornelia Karamus Rafał Wojciech Rejmak |
| author_sort | Martyna Borowska-Łygan |
| collection | DOAJ |
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Introduction and aim: Atopic dermatitis (AD) is a chronic inflammatory skin disease. It is characterised by periods of exacerbation and remission of symptoms such as pruritus, dry skin and eczematous lesions with characteristic morphology. The aim of this study is to present the current state of knowledge on new treatments for atopic dermatitis.
Review methods: The review was based on publicly available PubMed and Google Scholar databases from 2020 to 2024 using the following phrases: atopic dermatitis, treatment of atopic dermatitis, diagnosis of atopic dermatitis, epidemiology, biological treatment of atopic dermatitis, JAK inhibitors, stem cells, dermatitis.
Brief description of the state of the art: Atopic dermatitis is a disease whose mechanism of origin is incompletely understood.It involves interactions between genotype, environment, and the immune system, and is largely related to the T-cell response. The main symptom is pruritus and dry skin leading to lichenification or exfoliation of the epidermis, which characterise the chronic form. Diagnosis is confirmed by clinical criteria such as skin lesions characteristic of AD, a family predisposition to allergic disease and a full history and skin tests. Treatment focuses on managing the symptoms associated with the disease and improving the patient's quality of life using mainly corticosteroids, calcineurin inhibitors and antihistamines. Recent studies show positive effects of treatment with biologic drugs, JAK inhibitors, stem cells and provide great hope towards the development of treatments for atopic dermatitis.
Summary: The authors emphasise the need for further research towards the development of promising, innovative treatments for atopic dermatitis in order to significantly improve patients' quality of life.
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| format | Article |
| id | doaj-art-9b3c1b14ff8448f58d1b85ea05207813 |
| institution | Kabale University |
| issn | 2391-8306 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj-art-9b3c1b14ff8448f58d1b85ea052078132025-01-04T08:16:29ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062025-01-017710.12775/JEHS.2025.77.56830 Modern treatment methods in atopic dermatitis - literature overviewMartyna Borowska-Łygan0https://orcid.org/0009-0001-9402-7444Jakub Tomaszewski1https://orcid.org/0009-0009-9384-4643Wojciech Urban2https://orcid.org/0009-0009-1565-0595Konrad Strużek3https://orcid.org/0009-0000-3146-5132Jan Biłogras4https://orcid.org/0009-0002-6038-9217Kornelia Karamus5https://orcid.org/0000-0001-7453-1427Rafał Wojciech Rejmak6https://orcid.org/0009-0002-9422-8550Mazowiecki Szpital Specjalistyczny w Radomiu Uniwersytecki Szpital Kliniczny nr 4 w LublinieWojewódzki szpital specjalistyczny im Stefana Kardynała Wyszyńskiego SPZOZ w LublinieWojewódzki szpital specjalistyczny im Stefana Kardynała Wyszyńskiego SPZOZ w Lublinie1 Wojskowy Szpital Kliniczny z Polikliniką SPZOZ w LublinieUniwersytecki Szpital Kliniczny nr 4 w LublinieUniwersytecki Szpital Kliniczny nr 4 w Lublinie Introduction and aim: Atopic dermatitis (AD) is a chronic inflammatory skin disease. It is characterised by periods of exacerbation and remission of symptoms such as pruritus, dry skin and eczematous lesions with characteristic morphology. The aim of this study is to present the current state of knowledge on new treatments for atopic dermatitis. Review methods: The review was based on publicly available PubMed and Google Scholar databases from 2020 to 2024 using the following phrases: atopic dermatitis, treatment of atopic dermatitis, diagnosis of atopic dermatitis, epidemiology, biological treatment of atopic dermatitis, JAK inhibitors, stem cells, dermatitis. Brief description of the state of the art: Atopic dermatitis is a disease whose mechanism of origin is incompletely understood.It involves interactions between genotype, environment, and the immune system, and is largely related to the T-cell response. The main symptom is pruritus and dry skin leading to lichenification or exfoliation of the epidermis, which characterise the chronic form. Diagnosis is confirmed by clinical criteria such as skin lesions characteristic of AD, a family predisposition to allergic disease and a full history and skin tests. Treatment focuses on managing the symptoms associated with the disease and improving the patient's quality of life using mainly corticosteroids, calcineurin inhibitors and antihistamines. Recent studies show positive effects of treatment with biologic drugs, JAK inhibitors, stem cells and provide great hope towards the development of treatments for atopic dermatitis. Summary: The authors emphasise the need for further research towards the development of promising, innovative treatments for atopic dermatitis in order to significantly improve patients' quality of life. https://apcz.umk.pl/JEHS/article/view/56830atopic dermatitisatopic dermatitis treatmentJAK - inhibitorsbiological treatmentDupilumabtralokinumab |
| spellingShingle | Martyna Borowska-Łygan Jakub Tomaszewski Wojciech Urban Konrad Strużek Jan Biłogras Kornelia Karamus Rafał Wojciech Rejmak Modern treatment methods in atopic dermatitis - literature overview Journal of Education, Health and Sport atopic dermatitis atopic dermatitis treatment JAK - inhibitors biological treatment Dupilumab tralokinumab |
| title | Modern treatment methods in atopic dermatitis - literature overview |
| title_full | Modern treatment methods in atopic dermatitis - literature overview |
| title_fullStr | Modern treatment methods in atopic dermatitis - literature overview |
| title_full_unstemmed | Modern treatment methods in atopic dermatitis - literature overview |
| title_short | Modern treatment methods in atopic dermatitis - literature overview |
| title_sort | modern treatment methods in atopic dermatitis literature overview |
| topic | atopic dermatitis atopic dermatitis treatment JAK - inhibitors biological treatment Dupilumab tralokinumab |
| url | https://apcz.umk.pl/JEHS/article/view/56830 |
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