Combination of venetoclax with CHG regimen in refractory/relapsed T-lymphoblastic lymphoma/acute lymphoblastic leukemia: a case series and literature review
Abstract T lymphoblastic lymphoma/acute lymphoblastic leukemia (T-LBL/ALL) is a highly aggressive hematologic malignancy, with particularly poor outcomes for refractory/relapsed (R/R) patients. This article reports the efficacy and safety of V-CHG regimen (Venetoclax, cytarabine, homoharringtonine,...
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| Format: | Article |
| Language: | English |
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Springer
2025-07-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-03055-4 |
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| author | Mei Zhou Yuze Yang Xiaoyan Zhang Yijie Jiao Zhenxing Guo |
| author_facet | Mei Zhou Yuze Yang Xiaoyan Zhang Yijie Jiao Zhenxing Guo |
| author_sort | Mei Zhou |
| collection | DOAJ |
| description | Abstract T lymphoblastic lymphoma/acute lymphoblastic leukemia (T-LBL/ALL) is a highly aggressive hematologic malignancy, with particularly poor outcomes for refractory/relapsed (R/R) patients. This article reports the efficacy and safety of V-CHG regimen (Venetoclax, cytarabine, homoharringtonine, G-CSF) in the treatment of three R/R T-LBL/ALL cases. One 69 years old female patient with T-ALL experienced a twice relapse and achieved morphological complete remission (CR) with one cycle of V-CHG regimen. Another 65 years old female patient with T-LBL progressed to T-ALL after continuous CR for 10 months and failed by two different salvage chemotherapy regimens. She achieved minimal residual disease (MRD) negative CR with a third-line treatment based on V-CHG regimen. The third T-ALL patient was a 26 years old male who resistant to VDCP induction regimen and achieved morphological CR with one cycle of V-CHG regimen, and obtained MRD negative CR after second cycle treatment. All the three patients were well tolerated to the V-CHG regimen. The results of this study indicate that the V-CHG regimen is effective and safe for R/R T-LBL/ALL, warranting further application in the future. |
| format | Article |
| id | doaj-art-9af33304428a434c88009608e3d8229d |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-9af33304428a434c88009608e3d8229d2025-08-20T04:01:35ZengSpringerDiscover Oncology2730-60112025-07-011611810.1007/s12672-025-03055-4Combination of venetoclax with CHG regimen in refractory/relapsed T-lymphoblastic lymphoma/acute lymphoblastic leukemia: a case series and literature reviewMei Zhou0Yuze Yang1Xiaoyan Zhang2Yijie Jiao3Zhenxing Guo4Department of Hematology/Oncology, First Hospital of Tsinghua University, School of Medicine, Tsinghua UniversityDepartment of Hematology/Oncology, First Hospital of Tsinghua University, School of Medicine, Tsinghua UniversityDepartment of Hematology/Oncology, First Hospital of Tsinghua University, School of Medicine, Tsinghua UniversityDepartment of Hematology/Oncology, First Hospital of Tsinghua University, School of Medicine, Tsinghua UniversityDepartment of Hematology/Oncology, First Hospital of Tsinghua University, School of Medicine, Tsinghua UniversityAbstract T lymphoblastic lymphoma/acute lymphoblastic leukemia (T-LBL/ALL) is a highly aggressive hematologic malignancy, with particularly poor outcomes for refractory/relapsed (R/R) patients. This article reports the efficacy and safety of V-CHG regimen (Venetoclax, cytarabine, homoharringtonine, G-CSF) in the treatment of three R/R T-LBL/ALL cases. One 69 years old female patient with T-ALL experienced a twice relapse and achieved morphological complete remission (CR) with one cycle of V-CHG regimen. Another 65 years old female patient with T-LBL progressed to T-ALL after continuous CR for 10 months and failed by two different salvage chemotherapy regimens. She achieved minimal residual disease (MRD) negative CR with a third-line treatment based on V-CHG regimen. The third T-ALL patient was a 26 years old male who resistant to VDCP induction regimen and achieved morphological CR with one cycle of V-CHG regimen, and obtained MRD negative CR after second cycle treatment. All the three patients were well tolerated to the V-CHG regimen. The results of this study indicate that the V-CHG regimen is effective and safe for R/R T-LBL/ALL, warranting further application in the future.https://doi.org/10.1007/s12672-025-03055-4T lymphoblastic lymphoma/T acute lymphoblastic leukemiaVenetoclaxHomoharringtonineCHG regimenRefractory/relapsed |
| spellingShingle | Mei Zhou Yuze Yang Xiaoyan Zhang Yijie Jiao Zhenxing Guo Combination of venetoclax with CHG regimen in refractory/relapsed T-lymphoblastic lymphoma/acute lymphoblastic leukemia: a case series and literature review Discover Oncology T lymphoblastic lymphoma/T acute lymphoblastic leukemia Venetoclax Homoharringtonine CHG regimen Refractory/relapsed |
| title | Combination of venetoclax with CHG regimen in refractory/relapsed T-lymphoblastic lymphoma/acute lymphoblastic leukemia: a case series and literature review |
| title_full | Combination of venetoclax with CHG regimen in refractory/relapsed T-lymphoblastic lymphoma/acute lymphoblastic leukemia: a case series and literature review |
| title_fullStr | Combination of venetoclax with CHG regimen in refractory/relapsed T-lymphoblastic lymphoma/acute lymphoblastic leukemia: a case series and literature review |
| title_full_unstemmed | Combination of venetoclax with CHG regimen in refractory/relapsed T-lymphoblastic lymphoma/acute lymphoblastic leukemia: a case series and literature review |
| title_short | Combination of venetoclax with CHG regimen in refractory/relapsed T-lymphoblastic lymphoma/acute lymphoblastic leukemia: a case series and literature review |
| title_sort | combination of venetoclax with chg regimen in refractory relapsed t lymphoblastic lymphoma acute lymphoblastic leukemia a case series and literature review |
| topic | T lymphoblastic lymphoma/T acute lymphoblastic leukemia Venetoclax Homoharringtonine CHG regimen Refractory/relapsed |
| url | https://doi.org/10.1007/s12672-025-03055-4 |
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