Renal carcinoma associated with end-stage kidney disease: A case series from a tertiary Portuguese hospital
End-stage kidney disease (ESKD) is associated with a higher incidence of renal cell carcinoma (RCC). Here we report a case series of 56 patients with ESKD who underwent radical nephrectomy for suspected renal masses at a tertiary hospital in Portugal from January 2017 to January 2024. Patient recor...
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| Format: | Article |
| Language: | English |
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National Kidney Foundation of Ukraine
2024-10-01
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| Series: | Український Журнал Нефрології та Діалізу |
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| Online Access: | https://ukrjnd.com.ua/index.php/journal/article/view/887 |
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| author | João Ferreira Guerra João Magalhães Pina Vanessa Andrade Miguel Brito Lança Luís Campos Pinheiro |
| author_facet | João Ferreira Guerra João Magalhães Pina Vanessa Andrade Miguel Brito Lança Luís Campos Pinheiro |
| author_sort | João Ferreira Guerra |
| collection | DOAJ |
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End-stage kidney disease (ESKD) is associated with a higher incidence of renal cell carcinoma (RCC). Here we report a case series of 56 patients with ESKD who underwent radical nephrectomy for suspected renal masses at a tertiary hospital in Portugal from January 2017 to January 2024. Patient records were reviewed retrospectively to collect clinical, surgical, and pathological data. Among these patients, 12 had benign tumors, while 44 were diagnosed with malignant tumors, accounting for approximately 78.5% of the cohort. The histological analysis revealed the following distribution: clear cell RCC (20 cases, 45%), papillary RCC (11 cases, 25%), ACKD-associated RCC (6 cases, 14%), clear cell papillary RCC (4 cases, 9%), and chromophobe RCC (3 cases, 7%). Notably, the majority of patients (95.5%) had stage I malignant tumors, yet the prognosis for patients with ESKD was poorer compared to non-ESKD patients, with 7 patients succumbing during the follow-up period.
This study underscores the complex relationship between ESKD and RCC, highlighting the challenges in diagnosis and management. Despite regular monitoring leading to early detection of tumors, the overall prognosis remains adversely affected by the compromised immune status and comorbid conditions prevalent in this population. The findings call for enhanced surveillance and personalized management strategies for RCC in patients with ESKD.
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| format | Article |
| id | doaj-art-9af1ec3f58cb4ae181d4477b7d3fd67c |
| institution | Kabale University |
| issn | 2304-0238 2616-7352 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | National Kidney Foundation of Ukraine |
| record_format | Article |
| series | Український Журнал Нефрології та Діалізу |
| spelling | doaj-art-9af1ec3f58cb4ae181d4477b7d3fd67c2024-12-22T09:26:22ZengNational Kidney Foundation of UkraineУкраїнський Журнал Нефрології та Діалізу2304-02382616-73522024-10-014(84)10.31450/ukrjnd.4(84).2024.02Renal carcinoma associated with end-stage kidney disease: A case series from a tertiary Portuguese hospitalJoão Ferreira Guerra0João Magalhães Pina1Vanessa Andrade2Miguel Brito Lança3Luís Campos Pinheiro4Hospital de São José, Centro Hospitalar e Universitário de Lisboa Central, Lisbon, PortugalHospital de São José, Centro Hospitalar e Universitário de Lisboa Central, Lisbon, PortugalHospital de São José, Centro Hospitalar e Universitário de Lisboa Central, Lisbon, PortugalHospital de São José, Centro Hospitalar e Universitário de Lisboa Central, Lisbon, PortugalHospital de São José, Centro Hospitalar e Universitário de Lisboa Central, Lisbon, Portugal End-stage kidney disease (ESKD) is associated with a higher incidence of renal cell carcinoma (RCC). Here we report a case series of 56 patients with ESKD who underwent radical nephrectomy for suspected renal masses at a tertiary hospital in Portugal from January 2017 to January 2024. Patient records were reviewed retrospectively to collect clinical, surgical, and pathological data. Among these patients, 12 had benign tumors, while 44 were diagnosed with malignant tumors, accounting for approximately 78.5% of the cohort. The histological analysis revealed the following distribution: clear cell RCC (20 cases, 45%), papillary RCC (11 cases, 25%), ACKD-associated RCC (6 cases, 14%), clear cell papillary RCC (4 cases, 9%), and chromophobe RCC (3 cases, 7%). Notably, the majority of patients (95.5%) had stage I malignant tumors, yet the prognosis for patients with ESKD was poorer compared to non-ESKD patients, with 7 patients succumbing during the follow-up period. This study underscores the complex relationship between ESKD and RCC, highlighting the challenges in diagnosis and management. Despite regular monitoring leading to early detection of tumors, the overall prognosis remains adversely affected by the compromised immune status and comorbid conditions prevalent in this population. The findings call for enhanced surveillance and personalized management strategies for RCC in patients with ESKD. https://ukrjnd.com.ua/index.php/journal/article/view/887end-stage kidney disease, renal cell carcinoma, acquired cystic kidney disease, hemodialysis, pathology. |
| spellingShingle | João Ferreira Guerra João Magalhães Pina Vanessa Andrade Miguel Brito Lança Luís Campos Pinheiro Renal carcinoma associated with end-stage kidney disease: A case series from a tertiary Portuguese hospital Український Журнал Нефрології та Діалізу end-stage kidney disease, renal cell carcinoma, acquired cystic kidney disease, hemodialysis, pathology. |
| title | Renal carcinoma associated with end-stage kidney disease: A case series from a tertiary Portuguese hospital |
| title_full | Renal carcinoma associated with end-stage kidney disease: A case series from a tertiary Portuguese hospital |
| title_fullStr | Renal carcinoma associated with end-stage kidney disease: A case series from a tertiary Portuguese hospital |
| title_full_unstemmed | Renal carcinoma associated with end-stage kidney disease: A case series from a tertiary Portuguese hospital |
| title_short | Renal carcinoma associated with end-stage kidney disease: A case series from a tertiary Portuguese hospital |
| title_sort | renal carcinoma associated with end stage kidney disease a case series from a tertiary portuguese hospital |
| topic | end-stage kidney disease, renal cell carcinoma, acquired cystic kidney disease, hemodialysis, pathology. |
| url | https://ukrjnd.com.ua/index.php/journal/article/view/887 |
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