Relationships between genomic dissipation and de novo SNP evolution.
Patterns of single nucleotide polymorphisms (SNPs) in eukaryotic DNA are traditionally attributed to selective pressure, drift, identity descent, or related factors-without accounting for ways in which bias during de novo SNP formation, itself, might contribute. A functional and phenotypic analysis...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0303257&type=printable |
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| author | Zackery E Plyler Christopher W McAtee Aubrey E Hill Michael R Crowley Janice M Tindall Samuel R Tindall Disha Joshi Eric J Sorscher |
| author_facet | Zackery E Plyler Christopher W McAtee Aubrey E Hill Michael R Crowley Janice M Tindall Samuel R Tindall Disha Joshi Eric J Sorscher |
| author_sort | Zackery E Plyler |
| collection | DOAJ |
| description | Patterns of single nucleotide polymorphisms (SNPs) in eukaryotic DNA are traditionally attributed to selective pressure, drift, identity descent, or related factors-without accounting for ways in which bias during de novo SNP formation, itself, might contribute. A functional and phenotypic analysis based on evolutionary resilience of DNA points to decreased numbers of non-synonymous SNPs in human and other genomes, with a predominant component of SNP depletion in the human gene pool caused by robust preferences during de novo SNP formation (rather than selective constraint). Ramifications of these findings are broad, belie a number of concepts regarding human evolution, and point to a novel interpretation of evolving DNA across diverse species. |
| format | Article |
| id | doaj-art-9af081f218c24a57bacb27a06f5326c0 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-9af081f218c24a57bacb27a06f5326c02025-01-08T05:33:33ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-01195e030325710.1371/journal.pone.0303257Relationships between genomic dissipation and de novo SNP evolution.Zackery E PlylerChristopher W McAteeAubrey E HillMichael R CrowleyJanice M TindallSamuel R TindallDisha JoshiEric J SorscherPatterns of single nucleotide polymorphisms (SNPs) in eukaryotic DNA are traditionally attributed to selective pressure, drift, identity descent, or related factors-without accounting for ways in which bias during de novo SNP formation, itself, might contribute. A functional and phenotypic analysis based on evolutionary resilience of DNA points to decreased numbers of non-synonymous SNPs in human and other genomes, with a predominant component of SNP depletion in the human gene pool caused by robust preferences during de novo SNP formation (rather than selective constraint). Ramifications of these findings are broad, belie a number of concepts regarding human evolution, and point to a novel interpretation of evolving DNA across diverse species.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0303257&type=printable |
| spellingShingle | Zackery E Plyler Christopher W McAtee Aubrey E Hill Michael R Crowley Janice M Tindall Samuel R Tindall Disha Joshi Eric J Sorscher Relationships between genomic dissipation and de novo SNP evolution. PLoS ONE |
| title | Relationships between genomic dissipation and de novo SNP evolution. |
| title_full | Relationships between genomic dissipation and de novo SNP evolution. |
| title_fullStr | Relationships between genomic dissipation and de novo SNP evolution. |
| title_full_unstemmed | Relationships between genomic dissipation and de novo SNP evolution. |
| title_short | Relationships between genomic dissipation and de novo SNP evolution. |
| title_sort | relationships between genomic dissipation and de novo snp evolution |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0303257&type=printable |
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