Comprehensive Modular Synthesis of Ganglioside Glycans and Evaluation of their Binding Affinities to Siglec‐7 and Siglec‐9

Comprehensive Modular Synthesis of Ganglioside Glycans and Evaluation of their Binding Affinities to Siglec‐7 and Siglec‐9

Abstract In the present work, bacterial glycosyltransferases are utilized to construct ganglioside glycans in a convergent approach via a sugar‒nucleotide regeneration system and one‐pot multienzyme reactions. Starting from β‐lactoside enables the diversification of both the glycan moieties and the...

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Main Authors: Avijit K. Adak, Hsin‐Kai Tseng, Shu‐Yen Chang, Yu‐Ching Chiang, Ke‐Hong Lyu, Yun‐Sheng Lee, Wen Lu, Wen‐Hua Kuo, Takashi Angata, Chun‐Cheng Lin
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Advanced Science
Subjects:
carbohydrates
chemoenzymatic synthesis
gangliosides
glycan microarray
Siglec
Online Access:https://doi.org/10.1002/advs.202412815
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