Late observation of the neuroprotective effect of citicoline in uveitis: an impact on the ultrastructure of the choriocapillaris, retina and optic nerve in rabbits
Purpose: To evaluate the ultrastructure of the choriocapillaris, retina and optic nerve (ON) in citicoline-treated versus non-treated rabbits at the late time point after inducing non-infectious anterior and intermediate uveitis. Methods: The ultrastructure of the rabbit choriocapillaris, retina an...
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| Format: | Article |
| Language: | English |
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Ukrainian Society of Ophthalmologists
2024-12-01
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| Series: | Journal of Ophthalmology |
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| Online Access: | https://ua.ozhurnal.com/index.php/files/article/view/236 |
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| author | V. Ulianov I. Horianova N. Molchaniuk |
| author_facet | V. Ulianov I. Horianova N. Molchaniuk |
| author_sort | V. Ulianov |
| collection | DOAJ |
| description | Purpose: To evaluate the ultrastructure of the choriocapillaris, retina and optic nerve (ON) in citicoline-treated versus non-treated rabbits at the late time point after inducing non-infectious anterior and intermediate uveitis.
Methods: The ultrastructure of the rabbit choriocapillaris, retina and ON was evaluated at day 55 after the initiation of uveitis.
Results: Experimentally induced uveitis caused neurodegenerative changes in the retina and ON. Neuroprotective treatment activated intracellular compensative processes resulted in reduced signs of hydropic degeneration and normalized cell ultrastructure, and contributed to the activation of metabolism in ON glial cells and axoplasm.
Conclusion: Neuroprotective treatment for non-infectious anterior and intermediate uveitis resulted in a reduction in neurodegenerative changes in the retina and ON. |
| format | Article |
| id | doaj-art-9ab9c9bebb1c4e2089e443f2068fcb93 |
| institution | Kabale University |
| issn | 2412-8740 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Ukrainian Society of Ophthalmologists |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-9ab9c9bebb1c4e2089e443f2068fcb932025-01-07T10:36:12ZengUkrainian Society of OphthalmologistsJournal of Ophthalmology2412-87402024-12-016545910.31288/oftalmolzh202465459Late observation of the neuroprotective effect of citicoline in uveitis: an impact on the ultrastructure of the choriocapillaris, retina and optic nerve in rabbitsV. Ulianov0I. Horianova1https://orcid.org/0009-0004-0652-0709N. Molchaniuk2National University “Odesa Law Academy”SI "The Filatov Institute of Eye Diseases and Tissue Therapy of the NAMS of Ukraine"SI "The Filatov Institute of Eye Diseases and Tissue Therapy of the NAMS of Ukraine"Purpose: To evaluate the ultrastructure of the choriocapillaris, retina and optic nerve (ON) in citicoline-treated versus non-treated rabbits at the late time point after inducing non-infectious anterior and intermediate uveitis. Methods: The ultrastructure of the rabbit choriocapillaris, retina and ON was evaluated at day 55 after the initiation of uveitis. Results: Experimentally induced uveitis caused neurodegenerative changes in the retina and ON. Neuroprotective treatment activated intracellular compensative processes resulted in reduced signs of hydropic degeneration and normalized cell ultrastructure, and contributed to the activation of metabolism in ON glial cells and axoplasm. Conclusion: Neuroprotective treatment for non-infectious anterior and intermediate uveitis resulted in a reduction in neurodegenerative changes in the retina and ON.https://ua.ozhurnal.com/index.php/files/article/view/236anterior uveitisintermediate uveitisnon-infectious uveitis modelchoroidacute retinal pigment epitheliitisoptic nerveciticolinepathogenesis |
| spellingShingle | V. Ulianov I. Horianova N. Molchaniuk Late observation of the neuroprotective effect of citicoline in uveitis: an impact on the ultrastructure of the choriocapillaris, retina and optic nerve in rabbits Journal of Ophthalmology anterior uveitis intermediate uveitis non-infectious uveitis model choroid acute retinal pigment epitheliitis optic nerve citicoline pathogenesis |
| title | Late observation of the neuroprotective effect of citicoline in uveitis: an impact on the ultrastructure of the choriocapillaris, retina and optic nerve in rabbits |
| title_full | Late observation of the neuroprotective effect of citicoline in uveitis: an impact on the ultrastructure of the choriocapillaris, retina and optic nerve in rabbits |
| title_fullStr | Late observation of the neuroprotective effect of citicoline in uveitis: an impact on the ultrastructure of the choriocapillaris, retina and optic nerve in rabbits |
| title_full_unstemmed | Late observation of the neuroprotective effect of citicoline in uveitis: an impact on the ultrastructure of the choriocapillaris, retina and optic nerve in rabbits |
| title_short | Late observation of the neuroprotective effect of citicoline in uveitis: an impact on the ultrastructure of the choriocapillaris, retina and optic nerve in rabbits |
| title_sort | late observation of the neuroprotective effect of citicoline in uveitis an impact on the ultrastructure of the choriocapillaris retina and optic nerve in rabbits |
| topic | anterior uveitis intermediate uveitis non-infectious uveitis model choroid acute retinal pigment epitheliitis optic nerve citicoline pathogenesis |
| url | https://ua.ozhurnal.com/index.php/files/article/view/236 |
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