B-CLL with negative 18F-FDG PET/CT and intensive solitary lesion on PSMA PET/CT mimicking prostate cancer bone metastases
Abstract Positron emission tomography/computed tomography (PET/CT) using prostate-specific membrane antigen (PSMA)-radioligands is currently suggested by several clinical guidelines for the assessment of prostate cancer (PCa) in various clinical settings. However, PSMA will also be overexpressed in...
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Springer
2025-01-01
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| Series: | EJNMMI Reports |
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| Online Access: | https://doi.org/10.1186/s41824-024-00235-3 |
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| author | Theresa Jung Daniel Neureiter Gregor Schweighofer-Zwink Gundula Rendl Christian Pirich Mohsen Beheshti |
| author_facet | Theresa Jung Daniel Neureiter Gregor Schweighofer-Zwink Gundula Rendl Christian Pirich Mohsen Beheshti |
| author_sort | Theresa Jung |
| collection | DOAJ |
| description | Abstract Positron emission tomography/computed tomography (PET/CT) using prostate-specific membrane antigen (PSMA)-radioligands is currently suggested by several clinical guidelines for the assessment of prostate cancer (PCa) in various clinical settings. However, PSMA will also be overexpressed in different cancers, which should be considered on the PSMA PET/CT reading in patients with concomitant neoplastic diseases. We report a case of 82-year-old male presented with prostate and history of oesophageal cancer and B-cell chronic lymphocytic leukemia (B-CLL). Both 68Ga-PSMA-11 and 2-(3-(1-carboxy-5-((6-(18f)fluoro-pyridine-3-carbonyl)-amino)-pentyl)-ureido)-pentanedioic acid (18F-DCFPyL) PET/CT, which were performed for prostate cancer staging and re-staging in about 1 year interval, showed focal uptake in the primary prostate tumor as well as an intense focal lesion in L2, suggestive of bone metastasis. 18F-FDG PET/CT scans performed before and after PSMA PET/CT examinations showed no abnormal uptake related to oesophageal and/or B-CLL. This pattern could present an oligometastatic PCa disease, which might change the treatment plan of the patient to radiation of the bone metastasis. However, bone biopsy of the detected lesion on L2 revealed infiltrates of B-CLL. The role of 68Ga- and 18F-labeled PSMA PET/CT in prostate cancer is evolving and has been demonstrated to have high sensitivity, but may present limited specificity in patients with coexisting cancer(s), which should be considered in PSMA PET/CT reading. |
| format | Article |
| id | doaj-art-9a8fcba4940b4f3e9416a7a3194a3c2d |
| institution | Kabale University |
| issn | 3005-074X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Springer |
| record_format | Article |
| series | EJNMMI Reports |
| spelling | doaj-art-9a8fcba4940b4f3e9416a7a3194a3c2d2025-01-12T12:04:57ZengSpringerEJNMMI Reports3005-074X2025-01-01911310.1186/s41824-024-00235-3B-CLL with negative 18F-FDG PET/CT and intensive solitary lesion on PSMA PET/CT mimicking prostate cancer bone metastasesTheresa Jung0Daniel Neureiter1Gregor Schweighofer-Zwink2Gundula Rendl3Christian Pirich4Mohsen Beheshti5Division of Molecular Imaging and Theranostics, Department of Nuclear Medicine & Endocrinology, University Hospital, Paracelsus Medical University SalzburgInstitute of Pathology, University Hospital Salzburg, Paracelsus Medical UniversityDivision of Molecular Imaging and Theranostics, Department of Nuclear Medicine & Endocrinology, University Hospital, Paracelsus Medical University SalzburgDivision of Molecular Imaging and Theranostics, Department of Nuclear Medicine & Endocrinology, University Hospital, Paracelsus Medical University SalzburgDivision of Molecular Imaging and Theranostics, Department of Nuclear Medicine & Endocrinology, University Hospital, Paracelsus Medical University SalzburgDivision of Molecular Imaging and Theranostics, Department of Nuclear Medicine & Endocrinology, University Hospital, Paracelsus Medical University SalzburgAbstract Positron emission tomography/computed tomography (PET/CT) using prostate-specific membrane antigen (PSMA)-radioligands is currently suggested by several clinical guidelines for the assessment of prostate cancer (PCa) in various clinical settings. However, PSMA will also be overexpressed in different cancers, which should be considered on the PSMA PET/CT reading in patients with concomitant neoplastic diseases. We report a case of 82-year-old male presented with prostate and history of oesophageal cancer and B-cell chronic lymphocytic leukemia (B-CLL). Both 68Ga-PSMA-11 and 2-(3-(1-carboxy-5-((6-(18f)fluoro-pyridine-3-carbonyl)-amino)-pentyl)-ureido)-pentanedioic acid (18F-DCFPyL) PET/CT, which were performed for prostate cancer staging and re-staging in about 1 year interval, showed focal uptake in the primary prostate tumor as well as an intense focal lesion in L2, suggestive of bone metastasis. 18F-FDG PET/CT scans performed before and after PSMA PET/CT examinations showed no abnormal uptake related to oesophageal and/or B-CLL. This pattern could present an oligometastatic PCa disease, which might change the treatment plan of the patient to radiation of the bone metastasis. However, bone biopsy of the detected lesion on L2 revealed infiltrates of B-CLL. The role of 68Ga- and 18F-labeled PSMA PET/CT in prostate cancer is evolving and has been demonstrated to have high sensitivity, but may present limited specificity in patients with coexisting cancer(s), which should be considered in PSMA PET/CT reading.https://doi.org/10.1186/s41824-024-00235-3Prostate cancerB-CLLPET/CT18F-DCFPyL68Ga-PSMA-1118F-FDG |
| spellingShingle | Theresa Jung Daniel Neureiter Gregor Schweighofer-Zwink Gundula Rendl Christian Pirich Mohsen Beheshti B-CLL with negative 18F-FDG PET/CT and intensive solitary lesion on PSMA PET/CT mimicking prostate cancer bone metastases EJNMMI Reports Prostate cancer B-CLL PET/CT 18F-DCFPyL 68Ga-PSMA-11 18F-FDG |
| title | B-CLL with negative 18F-FDG PET/CT and intensive solitary lesion on PSMA PET/CT mimicking prostate cancer bone metastases |
| title_full | B-CLL with negative 18F-FDG PET/CT and intensive solitary lesion on PSMA PET/CT mimicking prostate cancer bone metastases |
| title_fullStr | B-CLL with negative 18F-FDG PET/CT and intensive solitary lesion on PSMA PET/CT mimicking prostate cancer bone metastases |
| title_full_unstemmed | B-CLL with negative 18F-FDG PET/CT and intensive solitary lesion on PSMA PET/CT mimicking prostate cancer bone metastases |
| title_short | B-CLL with negative 18F-FDG PET/CT and intensive solitary lesion on PSMA PET/CT mimicking prostate cancer bone metastases |
| title_sort | b cll with negative 18f fdg pet ct and intensive solitary lesion on psma pet ct mimicking prostate cancer bone metastases |
| topic | Prostate cancer B-CLL PET/CT 18F-DCFPyL 68Ga-PSMA-11 18F-FDG |
| url | https://doi.org/10.1186/s41824-024-00235-3 |
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