Research priorities for improving cognitive and neuropsychological outcomes in hydrocephalus
Abstract Hydrocephalus is a neurological disorder that impacts approximately 85 per 100,000 individuals worldwide and is associated with motor and cognitive impairments. While many advances in surgical interventions have helped substantially improve the survival rates and quality of life of those af...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-12-01
|
| Series: | Fluids and Barriers of the CNS |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12987-024-00602-z |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841559157895856128 |
|---|---|
| author | Nickolas Dasher T. Andrew Zabel Maria Garcia-Bonilla Lauren L. Jantzie Mark G. Hamilton Michael A. Williams Monica J. Chau |
| author_facet | Nickolas Dasher T. Andrew Zabel Maria Garcia-Bonilla Lauren L. Jantzie Mark G. Hamilton Michael A. Williams Monica J. Chau |
| author_sort | Nickolas Dasher |
| collection | DOAJ |
| description | Abstract Hydrocephalus is a neurological disorder that impacts approximately 85 per 100,000 individuals worldwide and is associated with motor and cognitive impairments. While many advances in surgical interventions have helped substantially improve the survival rates and quality of life of those affected, there continues to be significant gaps in our understanding of the etiology of this heterogeneous condition as well as its specific neuropsychological and functional challenges across different phases of life. To address these limitations, the Hydrocephalus Association and Rudi Schulte Research Institute organized a workshop titled, “Improving Cognitive and Psychological Outcomes in Hydrocephalus”, composed of top academics in the fields of hydrocephalus, cognition, and neuropsychology, as well as individuals with hydrocephalus or their caregivers. The purpose was to review the available evidence and propose pertinent areas of further research to improve the cognitive functioning, functional status, and quality of life of individuals with hydrocephalus. These topics included cognitive and neuropsychological assessments and daily-life function of children and adults living with hydrocephalus, biomarkers of cognitive function, animal modeling of hydrocephalus, and the longitudinal impact of hydrocephalus treatment. The following paper outlines four primary areas that warrant research: (1) neuropsychological phenotypes, (2) treatment-focused research considerations, (3) translational pre-clinical tools, and (4) establishing pathways for longitudinal care. Through the efforts of this group, the goal of this manuscript is to inspire and direct scientific and clinical inquiry towards these noted research priorities to further improve the lives of individuals with hydrocephalus and their families. |
| format | Article |
| id | doaj-art-9a771fae8ff54a8e99475c74712996ad |
| institution | Kabale University |
| issn | 2045-8118 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Fluids and Barriers of the CNS |
| spelling | doaj-art-9a771fae8ff54a8e99475c74712996ad2025-01-05T12:43:25ZengBMCFluids and Barriers of the CNS2045-81182024-12-0121111210.1186/s12987-024-00602-zResearch priorities for improving cognitive and neuropsychological outcomes in hydrocephalusNickolas Dasher0T. Andrew Zabel1Maria Garcia-Bonilla2Lauren L. Jantzie3Mark G. Hamilton4Michael A. Williams5Monica J. Chau6Department of Rehabilitation Medicine, University of Washington School of MedicineKennedy Krieger InstituteDepartment of Neurosurgery, Virginia Commonwealth University School of MedicineDepartment of Pediatrics, Division of Neonatal-Perinatal Medicine, Johns Hopkins University School of MedicineDivision of Neurosurgery, Department of Clinical Neurosciences, Cumming School of Medicine Foothills HospitalDepartments of Neurology and Neurological Surgery, University of Washington School of MedicineHydrocephalus AssociationAbstract Hydrocephalus is a neurological disorder that impacts approximately 85 per 100,000 individuals worldwide and is associated with motor and cognitive impairments. While many advances in surgical interventions have helped substantially improve the survival rates and quality of life of those affected, there continues to be significant gaps in our understanding of the etiology of this heterogeneous condition as well as its specific neuropsychological and functional challenges across different phases of life. To address these limitations, the Hydrocephalus Association and Rudi Schulte Research Institute organized a workshop titled, “Improving Cognitive and Psychological Outcomes in Hydrocephalus”, composed of top academics in the fields of hydrocephalus, cognition, and neuropsychology, as well as individuals with hydrocephalus or their caregivers. The purpose was to review the available evidence and propose pertinent areas of further research to improve the cognitive functioning, functional status, and quality of life of individuals with hydrocephalus. These topics included cognitive and neuropsychological assessments and daily-life function of children and adults living with hydrocephalus, biomarkers of cognitive function, animal modeling of hydrocephalus, and the longitudinal impact of hydrocephalus treatment. The following paper outlines four primary areas that warrant research: (1) neuropsychological phenotypes, (2) treatment-focused research considerations, (3) translational pre-clinical tools, and (4) establishing pathways for longitudinal care. Through the efforts of this group, the goal of this manuscript is to inspire and direct scientific and clinical inquiry towards these noted research priorities to further improve the lives of individuals with hydrocephalus and their families.https://doi.org/10.1186/s12987-024-00602-zHydrocephalusNeuropsychologyCognitionResearch priorities |
| spellingShingle | Nickolas Dasher T. Andrew Zabel Maria Garcia-Bonilla Lauren L. Jantzie Mark G. Hamilton Michael A. Williams Monica J. Chau Research priorities for improving cognitive and neuropsychological outcomes in hydrocephalus Fluids and Barriers of the CNS Hydrocephalus Neuropsychology Cognition Research priorities |
| title | Research priorities for improving cognitive and neuropsychological outcomes in hydrocephalus |
| title_full | Research priorities for improving cognitive and neuropsychological outcomes in hydrocephalus |
| title_fullStr | Research priorities for improving cognitive and neuropsychological outcomes in hydrocephalus |
| title_full_unstemmed | Research priorities for improving cognitive and neuropsychological outcomes in hydrocephalus |
| title_short | Research priorities for improving cognitive and neuropsychological outcomes in hydrocephalus |
| title_sort | research priorities for improving cognitive and neuropsychological outcomes in hydrocephalus |
| topic | Hydrocephalus Neuropsychology Cognition Research priorities |
| url | https://doi.org/10.1186/s12987-024-00602-z |
| work_keys_str_mv | AT nickolasdasher researchprioritiesforimprovingcognitiveandneuropsychologicaloutcomesinhydrocephalus AT tandrewzabel researchprioritiesforimprovingcognitiveandneuropsychologicaloutcomesinhydrocephalus AT mariagarciabonilla researchprioritiesforimprovingcognitiveandneuropsychologicaloutcomesinhydrocephalus AT laurenljantzie researchprioritiesforimprovingcognitiveandneuropsychologicaloutcomesinhydrocephalus AT markghamilton researchprioritiesforimprovingcognitiveandneuropsychologicaloutcomesinhydrocephalus AT michaelawilliams researchprioritiesforimprovingcognitiveandneuropsychologicaloutcomesinhydrocephalus AT monicajchau researchprioritiesforimprovingcognitiveandneuropsychologicaloutcomesinhydrocephalus |