Clustering patients with COVID-19 according to respiratory support requirements, and its impact on short- and long-term outcome (RECOVID study)
Introduction The Spanish Society of Pulmonology and Thoracic Surgery created a registry for hospitalised patients with COVID-19 and the different types of respiratory support used (RECOVID). Objectives. To describe the profile of hospitalised patients with COVID-19, comorbidities, respiratory suppor...
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Taylor & Francis
2025-12-01
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| Series: | Pulmonology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/25310429.2024.2442175 |
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| author | Rosario Menéndez Raúl Méndez Ana Latorre Paula González-Jiménez Germán Peces-Barba María Molina-Molina Pedro Pablo España Estela García Angélica Consuegra-Vanegas Marta María García-Clemente Carolina Panadero Juan Marco Figueira-Gonçalves David De la Rosa-Carrillo Oriol Sibila María Dolores Martínez-Pitarch Nuria Toledo-Pons Cecilia López-Ramírez Wanda Almonte-Batista Abigail Macías-Paredes Mercedes Villamon Marisol Domínguez-Álvarez Eli Nancy Pérez-Rodas Javier Lázaro Sarai Quirós Rosa Cordovilla Irene Cano-Pumarega Antoni Torres |
| author_facet | Rosario Menéndez Raúl Méndez Ana Latorre Paula González-Jiménez Germán Peces-Barba María Molina-Molina Pedro Pablo España Estela García Angélica Consuegra-Vanegas Marta María García-Clemente Carolina Panadero Juan Marco Figueira-Gonçalves David De la Rosa-Carrillo Oriol Sibila María Dolores Martínez-Pitarch Nuria Toledo-Pons Cecilia López-Ramírez Wanda Almonte-Batista Abigail Macías-Paredes Mercedes Villamon Marisol Domínguez-Álvarez Eli Nancy Pérez-Rodas Javier Lázaro Sarai Quirós Rosa Cordovilla Irene Cano-Pumarega Antoni Torres |
| author_sort | Rosario Menéndez |
| collection | DOAJ |
| description | Introduction The Spanish Society of Pulmonology and Thoracic Surgery created a registry for hospitalised patients with COVID-19 and the different types of respiratory support used (RECOVID). Objectives. To describe the profile of hospitalised patients with COVID-19, comorbidities, respiratory support treatments and setting. In addition, we aimed to identify varying profiles of patients according to outcomes and the complexity of respiratory support needed.Methods Multicentre, observational study in 49 Spanish hospitals. A protocol collected demographic data, comorbidities, respiratory support, treatment setting and 1-year follow-up. Patients were described using either frequency and percentages or median and interquartile range, as appropriate. A cluster analysis made it possible to identify different types of profile among the patients.Results In total, 2148 of 2454 hospitalised patients (87.5%) received care in the conventional ward, whilst 126 in IRCU and 180 in ICU. In IRCU, 30% required high-flow nasal oxygen whilst 25%, non-invasive mechanical ventilation and 17%, mechanical ventilation. Four clusters of patients were identified. Two clusters were more likely to require IRCU/ICU admission, although primarily Cluster 2: Cluster (C) 1 consisted of patients without comorbidities and C2, those with comorbidities. Both presented higher inflammatory levels and lower lymphocyte count and SpO2/FiO2; however, C2 showed worse values. Two different clusters identified patients requiring less complex respiratory support. C3 presented higher comorbidities and elevated lymphocyte count, SpO2/FiO2 and low C-reactive protein (CRP). C4 included those without comorbidities except for arterial hypertension, lymphopenia and an intermediate CRP. In-hospital mortality and subsequent 1-year mortality were greater for C2 (28.6% and 7.1%) and C1 (11.1%, 8.3%) than for C4 (3.3%, 1.8%) and C3 (0%, 0%).Conclusions The cluster analysis identified four clinical phenotypes requiring distinct types of respiratory support, with great differences present per characteristics and outcomes. |
| format | Article |
| id | doaj-art-9a75d1ea98544dd6951eebc087ebb3dd |
| institution | Kabale University |
| issn | 2531-0429 2531-0437 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis |
| record_format | Article |
| series | Pulmonology |
| spelling | doaj-art-9a75d1ea98544dd6951eebc087ebb3dd2025-01-03T15:12:30ZengTaylor & FrancisPulmonology2531-04292531-04372025-12-0131110.1080/25310429.2024.2442175Clustering patients with COVID-19 according to respiratory support requirements, and its impact on short- and long-term outcome (RECOVID study)Rosario Menéndez0Raúl Méndez1Ana Latorre2Paula González-Jiménez3Germán Peces-Barba4María Molina-Molina5Pedro Pablo España6Estela García7Angélica Consuegra-Vanegas8Marta María García-Clemente9Carolina Panadero10Juan Marco Figueira-Gonçalves11David De la Rosa-Carrillo12Oriol Sibila13María Dolores Martínez-Pitarch14Nuria Toledo-Pons15Cecilia López-Ramírez16Wanda Almonte-Batista17Abigail Macías-Paredes18Mercedes Villamon19Marisol Domínguez-Álvarez20Eli Nancy Pérez-Rodas21Javier Lázaro22Sarai Quirós23Rosa Cordovilla24Irene Cano-Pumarega25Antoni Torres26Pneumology Service, Hospital Universitario y Politécnico La Fe, Valencia, SpainPneumology Service, Hospital Universitario y Politécnico La Fe, Valencia, SpainRespiratory Infections, Research Institute La Fe (IISLAFE), Valencia, SpainPneumology Service, Hospital Universitario y Politécnico La Fe, Valencia, SpainPneumology Service, Hospital Fundación Jiménez Díaz, Madrid, SpainILD Unit, Pneumology Service, Hospital Universitario de Bellvitge-IDIBELL, Hospitalet de Llobregat, Hospitalet de Llobregat, SpainPneumology Service, Hospital de Galdakao-Usansolo, Galdakao, SpainPneumology Service, Hospital de Cabueñes, Gijón, SpainPneumology Service, Hospital Universitario de A Coruña, A Coruña, SpainPneumology Service, Hospital Universitario Central de Asturias, Oviedo, SpainPneumology Service, Hospital de Getafe, Getafe, SpainPneumology Service, Hospital Nuestra Señora de la Candelaria, Santa Cruz de Tenerife, SpainPneumology Service, Hospital de la Santa Creu i Sant Pau, Barcelona, SpainPneumology Service, Hospital Clínic, Barcelona, SpainPneumology Service, Hospital Lluís Alcanyís, Játiva, SpainPneumology Service, Hospital Son Espases-Balearic Islands Health Research Institute (IdISBa), Palma, SpainPneumology Service, Hospital Virgen del Rocío, Sevilla, SpainPneumology Service, Hospital de Albacete, Albacete, SpainPneumology Service, Hospital de Sant Jaume, Calella, SpainPneumology Service, Hospital Santa Lucía, Cartagena, SpainPneumology Service, Hospital del Mar, Barcelona, SpainPneumology Service, Hospital Dos de Mayo, Barcelona, SpainPneumology Service, Hospital Royo Villanova, Zaragoza, SpainPneumology Service, Hospital Basurto, Bilbao, SpainPneumology Service, Hospital de Salamanca, Salamanca, SpainSleep Unit, Pneumology Service, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, SpainPneumology Service, Hospital Clínic, Barcelona, SpainIntroduction The Spanish Society of Pulmonology and Thoracic Surgery created a registry for hospitalised patients with COVID-19 and the different types of respiratory support used (RECOVID). Objectives. To describe the profile of hospitalised patients with COVID-19, comorbidities, respiratory support treatments and setting. In addition, we aimed to identify varying profiles of patients according to outcomes and the complexity of respiratory support needed.Methods Multicentre, observational study in 49 Spanish hospitals. A protocol collected demographic data, comorbidities, respiratory support, treatment setting and 1-year follow-up. Patients were described using either frequency and percentages or median and interquartile range, as appropriate. A cluster analysis made it possible to identify different types of profile among the patients.Results In total, 2148 of 2454 hospitalised patients (87.5%) received care in the conventional ward, whilst 126 in IRCU and 180 in ICU. In IRCU, 30% required high-flow nasal oxygen whilst 25%, non-invasive mechanical ventilation and 17%, mechanical ventilation. Four clusters of patients were identified. Two clusters were more likely to require IRCU/ICU admission, although primarily Cluster 2: Cluster (C) 1 consisted of patients without comorbidities and C2, those with comorbidities. Both presented higher inflammatory levels and lower lymphocyte count and SpO2/FiO2; however, C2 showed worse values. Two different clusters identified patients requiring less complex respiratory support. C3 presented higher comorbidities and elevated lymphocyte count, SpO2/FiO2 and low C-reactive protein (CRP). C4 included those without comorbidities except for arterial hypertension, lymphopenia and an intermediate CRP. In-hospital mortality and subsequent 1-year mortality were greater for C2 (28.6% and 7.1%) and C1 (11.1%, 8.3%) than for C4 (3.3%, 1.8%) and C3 (0%, 0%).Conclusions The cluster analysis identified four clinical phenotypes requiring distinct types of respiratory support, with great differences present per characteristics and outcomes.https://www.tandfonline.com/doi/10.1080/25310429.2024.2442175RECOVIDCOVID-19SARS-CoV-2SEPARNIMV |
| spellingShingle | Rosario Menéndez Raúl Méndez Ana Latorre Paula González-Jiménez Germán Peces-Barba María Molina-Molina Pedro Pablo España Estela García Angélica Consuegra-Vanegas Marta María García-Clemente Carolina Panadero Juan Marco Figueira-Gonçalves David De la Rosa-Carrillo Oriol Sibila María Dolores Martínez-Pitarch Nuria Toledo-Pons Cecilia López-Ramírez Wanda Almonte-Batista Abigail Macías-Paredes Mercedes Villamon Marisol Domínguez-Álvarez Eli Nancy Pérez-Rodas Javier Lázaro Sarai Quirós Rosa Cordovilla Irene Cano-Pumarega Antoni Torres Clustering patients with COVID-19 according to respiratory support requirements, and its impact on short- and long-term outcome (RECOVID study) Pulmonology RECOVID COVID-19 SARS-CoV-2 SEPAR NIMV |
| title | Clustering patients with COVID-19 according to respiratory support requirements, and its impact on short- and long-term outcome (RECOVID study) |
| title_full | Clustering patients with COVID-19 according to respiratory support requirements, and its impact on short- and long-term outcome (RECOVID study) |
| title_fullStr | Clustering patients with COVID-19 according to respiratory support requirements, and its impact on short- and long-term outcome (RECOVID study) |
| title_full_unstemmed | Clustering patients with COVID-19 according to respiratory support requirements, and its impact on short- and long-term outcome (RECOVID study) |
| title_short | Clustering patients with COVID-19 according to respiratory support requirements, and its impact on short- and long-term outcome (RECOVID study) |
| title_sort | clustering patients with covid 19 according to respiratory support requirements and its impact on short and long term outcome recovid study |
| topic | RECOVID COVID-19 SARS-CoV-2 SEPAR NIMV |
| url | https://www.tandfonline.com/doi/10.1080/25310429.2024.2442175 |
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