Antibacterial therapy of sepsis in extracorporeal detoxication: current problems and ways to solve them
The effectiveness of antibacterial therapy is a critical factor to improve treatment outcomes in sepsis patients. Impaired renal function and renal replacement therapy lead to a significant change in the pharmacokinetic parameters of most intravenous antibacterial drugs, which in many cases is accom...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2020-12-01
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| Series: | Вестник анестезиологии и реаниматологии |
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| Online Access: | https://www.vair-journal.com/jour/article/view/484 |
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| _version_ | 1849252805344231424 |
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| author | A. V. Marukhov M. V. Zakharov N. V. Chubchenko A. N. Belskikh L. V. Buryakova D. Yu. Lazarenko |
| author_facet | A. V. Marukhov M. V. Zakharov N. V. Chubchenko A. N. Belskikh L. V. Buryakova D. Yu. Lazarenko |
| author_sort | A. V. Marukhov |
| collection | DOAJ |
| description | The effectiveness of antibacterial therapy is a critical factor to improve treatment outcomes in sepsis patients. Impaired renal function and renal replacement therapy lead to a significant change in the pharmacokinetic parameters of most intravenous antibacterial drugs, which in many cases is accompanied by insufficient or excessive concentration in the blood which results in antibacterial therapy failure. The article presents current views and describes the current problems of antibacterial therapy for sepsis during the use of extracorporeal detoxification methods.The objective: to analyze publications on antibacterial therapy of sepsis during the extracorporeal detoxification.Results: the most accessible and effective method for solving the problem of inadequate dosage of antibiotics when using extracorporeal detoxification is to develop local protocols based on the results of pharmacokinetic studies. |
| format | Article |
| id | doaj-art-9a64c421ab434843b20035a2c423b7f5 |
| institution | Kabale University |
| issn | 2078-5658 2541-8653 |
| language | Russian |
| publishDate | 2020-12-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Вестник анестезиологии и реаниматологии |
| spelling | doaj-art-9a64c421ab434843b20035a2c423b7f52025-08-20T03:56:32ZrusNew Terra Publishing HouseВестник анестезиологии и реаниматологии2078-56582541-86532020-12-01176808710.21292/2078-5658-2020-17-6-80-87421Antibacterial therapy of sepsis in extracorporeal detoxication: current problems and ways to solve themA. V. Marukhov0M. V. Zakharov1N. V. Chubchenko2A. N. Belskikh3L. V. Buryakova4D. Yu. Lazarenko5S.M. Kirov Military Medical AcademyS.M. Kirov Military Medical AcademyS.M. Kirov Military Medical AcademyS.M. Kirov Military Medical AcademyS.M. Kirov Military Medical AcademyS.M. Kirov Military Medical AcademyThe effectiveness of antibacterial therapy is a critical factor to improve treatment outcomes in sepsis patients. Impaired renal function and renal replacement therapy lead to a significant change in the pharmacokinetic parameters of most intravenous antibacterial drugs, which in many cases is accompanied by insufficient or excessive concentration in the blood which results in antibacterial therapy failure. The article presents current views and describes the current problems of antibacterial therapy for sepsis during the use of extracorporeal detoxification methods.The objective: to analyze publications on antibacterial therapy of sepsis during the extracorporeal detoxification.Results: the most accessible and effective method for solving the problem of inadequate dosage of antibiotics when using extracorporeal detoxification is to develop local protocols based on the results of pharmacokinetic studies.https://www.vair-journal.com/jour/article/view/484extracorporeal detoxificationrenal replacement therapyantibacterial therapypharmacokinetics |
| spellingShingle | A. V. Marukhov M. V. Zakharov N. V. Chubchenko A. N. Belskikh L. V. Buryakova D. Yu. Lazarenko Antibacterial therapy of sepsis in extracorporeal detoxication: current problems and ways to solve them Вестник анестезиологии и реаниматологии extracorporeal detoxification renal replacement therapy antibacterial therapy pharmacokinetics |
| title | Antibacterial therapy of sepsis in extracorporeal detoxication: current problems and ways to solve them |
| title_full | Antibacterial therapy of sepsis in extracorporeal detoxication: current problems and ways to solve them |
| title_fullStr | Antibacterial therapy of sepsis in extracorporeal detoxication: current problems and ways to solve them |
| title_full_unstemmed | Antibacterial therapy of sepsis in extracorporeal detoxication: current problems and ways to solve them |
| title_short | Antibacterial therapy of sepsis in extracorporeal detoxication: current problems and ways to solve them |
| title_sort | antibacterial therapy of sepsis in extracorporeal detoxication current problems and ways to solve them |
| topic | extracorporeal detoxification renal replacement therapy antibacterial therapy pharmacokinetics |
| url | https://www.vair-journal.com/jour/article/view/484 |
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