The importance of stem cells in the treatment of type 1 diabetes, type 2 diabetes and diabetes complications
Introduction and Purpose. Diabetes, characterized by hyperglycemia due to impaired insulin production or action, leads to significant complications like diabetic retinopathy (DR) and diabetic foot syndrome (DFS). Current treatments manage symptoms but do not fully address disease progression. Stem...
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Nicolaus Copernicus University in Toruń
2025-01-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/57420 |
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| author | Monika Kamińska Maria Jasiewicz Magdalena Miernik-Skrzypczak Aleksandra Spyra Marta Malicka Natalia Dąbrowska Aleksandra Kozioł Katarzyna Moczyróg |
| author_facet | Monika Kamińska Maria Jasiewicz Magdalena Miernik-Skrzypczak Aleksandra Spyra Marta Malicka Natalia Dąbrowska Aleksandra Kozioł Katarzyna Moczyróg |
| author_sort | Monika Kamińska |
| collection | DOAJ |
| description |
Introduction and Purpose. Diabetes, characterized by hyperglycemia due to impaired insulin production or action, leads to significant complications like diabetic retinopathy (DR) and diabetic foot syndrome (DFS). Current treatments manage symptoms but do not fully address disease progression. Stem cells, with their regenerative potential and immunomodulatory properties, represent a promising avenue for treating diabetes and its complications. This study explores the use of stem cell therapy in managing type 1 and type 2 diabetes, DR, and DFS.
Material and Method. The study reviewed existing literature on the application of stem cells in diabetes treatment. More than 30 articles addressing these issues were analyzed. They were found using the PubMed search engine, and the time frame of these publications covered the last 20 years.
Results. Stem cells demonstrated significant potential in diabetes management. For type 1 diabetes, MSCs reduced inflammation, preserved pancreatic islet function, and decreased insulin requirements without major adverse effects. Pluripotent stem cells showed promise in islet transplantation, achieving stable glycemic control in clinical trials. In type 2 diabetes, stem cell therapy improved insulin sensitivity and reduced insulin dependency, with evidence of β-cell regeneration. Complications like diabetic foot ulcers and retinopathy also responded positively to stem cell treatments. MSCs improved wound healing by enhancing tissue regeneration and reducing inflammation, while retinal therapies showed promise in slowing disease progression and repairing damaged vasculature.
Conclusions. Stem cell therapies offer a promising approach for diabetes and its complications, particularly for regenerative applications in DR and DFS. While initial results are encouraging, further large-scale studies are needed to optimize protocols, assess long-term safety, and establish standardized clinical applications.
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| format | Article |
| id | doaj-art-9a5648fd1e11478da32b81ce1c380a83 |
| institution | Kabale University |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-9a5648fd1e11478da32b81ce1c380a832025-01-15T08:23:08ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-01-013710.12775/QS.2025.37.57420The importance of stem cells in the treatment of type 1 diabetes, type 2 diabetes and diabetes complicationsMonika Kamińska0https://orcid.org/0000-0003-4968-9219Maria Jasiewicz1https://orcid.org/0009-0008-0718-2528Magdalena Miernik-Skrzypczak2https://orcid.org/0009-0004-0987-1686Aleksandra Spyra3https://orcid.org/0009-0007-2288-6411Marta Malicka4https://orcid.org/0009-0009-1955-6512Natalia Dąbrowska5https://orcid.org/0009-0009-7170-0614Aleksandra Kozioł6https://orcid.org/0009-0008-8692-0647Katarzyna Moczyróg7https://orcid.org/0009-0002-3353-2444Provincial Hospital in Kielce, 45 Grunwaldzka Street, 25-736 Kielce, PolandMedical Center in Łańcut, 5 Paderewskiego Street, 37-100 Łańcut, PolandLower Silesian Center for Oncology, Pulmonology, and Hematology, 12 Hirszfeld Square, 53-413 Wrocław, PolandSilesian Centre for Heart Diseases, 9 Marii Curie Skłodowskiej Street, 41-800 Zabrze, PolandUniversity Hospital in Wrocław, 213 Borowska Street, 50-556 Wrocław, PolandMilitary Institute of Medicine - National Research Institute: Warsaw, 128 Szaserów Street, 04-141 Warszawa, PolandUniversity Hospital in Wrocław, 213 Borowska Street, 50-556 Wrocław, PolandThe Sergeant Grzegorz Załoga Hospital of the Ministry of the Interior and Administration, ul. Wita Stwosza 39-41, 40-042 Katowice, Poland Introduction and Purpose. Diabetes, characterized by hyperglycemia due to impaired insulin production or action, leads to significant complications like diabetic retinopathy (DR) and diabetic foot syndrome (DFS). Current treatments manage symptoms but do not fully address disease progression. Stem cells, with their regenerative potential and immunomodulatory properties, represent a promising avenue for treating diabetes and its complications. This study explores the use of stem cell therapy in managing type 1 and type 2 diabetes, DR, and DFS. Material and Method. The study reviewed existing literature on the application of stem cells in diabetes treatment. More than 30 articles addressing these issues were analyzed. They were found using the PubMed search engine, and the time frame of these publications covered the last 20 years. Results. Stem cells demonstrated significant potential in diabetes management. For type 1 diabetes, MSCs reduced inflammation, preserved pancreatic islet function, and decreased insulin requirements without major adverse effects. Pluripotent stem cells showed promise in islet transplantation, achieving stable glycemic control in clinical trials. In type 2 diabetes, stem cell therapy improved insulin sensitivity and reduced insulin dependency, with evidence of β-cell regeneration. Complications like diabetic foot ulcers and retinopathy also responded positively to stem cell treatments. MSCs improved wound healing by enhancing tissue regeneration and reducing inflammation, while retinal therapies showed promise in slowing disease progression and repairing damaged vasculature. Conclusions. Stem cell therapies offer a promising approach for diabetes and its complications, particularly for regenerative applications in DR and DFS. While initial results are encouraging, further large-scale studies are needed to optimize protocols, assess long-term safety, and establish standardized clinical applications. https://apcz.umk.pl/QS/article/view/57420stem cellsdiabetes mellitus type 1diabetes mellitus type 2diabetic retinopathywound |
| spellingShingle | Monika Kamińska Maria Jasiewicz Magdalena Miernik-Skrzypczak Aleksandra Spyra Marta Malicka Natalia Dąbrowska Aleksandra Kozioł Katarzyna Moczyróg The importance of stem cells in the treatment of type 1 diabetes, type 2 diabetes and diabetes complications Quality in Sport stem cells diabetes mellitus type 1 diabetes mellitus type 2 diabetic retinopathy wound |
| title | The importance of stem cells in the treatment of type 1 diabetes, type 2 diabetes and diabetes complications |
| title_full | The importance of stem cells in the treatment of type 1 diabetes, type 2 diabetes and diabetes complications |
| title_fullStr | The importance of stem cells in the treatment of type 1 diabetes, type 2 diabetes and diabetes complications |
| title_full_unstemmed | The importance of stem cells in the treatment of type 1 diabetes, type 2 diabetes and diabetes complications |
| title_short | The importance of stem cells in the treatment of type 1 diabetes, type 2 diabetes and diabetes complications |
| title_sort | importance of stem cells in the treatment of type 1 diabetes type 2 diabetes and diabetes complications |
| topic | stem cells diabetes mellitus type 1 diabetes mellitus type 2 diabetic retinopathy wound |
| url | https://apcz.umk.pl/QS/article/view/57420 |
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